2012 NeoReviews Disclosure

2012 2011 2010

The American Academy of Pediatrics (AAP) Continuing Medical Education (CME) program aims to develop, maintain, and improve the competence, skills and professional performance of neonatologists and neonatal/perinatal healthcare professionals by providing quality, relevant, accessible, and effective educational experiences that address gaps in professional practice. The AAP CME program strives to meet participants educational needs and support their life-long learning with a goal of improving care for children and families (AAP CME Program Mission Statement, October 2010). In keeping with this spirit, the information that follows is being communicated to all learners before beginning this CME activity.

NeoReviews is the online neonatology review journal published by the American Academy of Pediatrics (AAP) to help neonatologists, neonatal and perinatal practitioners, and allied health clinicians stay current with authoritative review articles, professional resources, and quizzes accessible online at any time. This online journal CME activity offers rigorously peer-reviewed articles mapped to the American Board of Pediatrics (ABP) content specifications in neonatal and perinatal medicine and helpful in preparing for maintenance of certification MOC in neonatology. The learning objectives for this module are the following: To assist participants in acquiring and updating the knowledge and skills needed to facilitate good health and manage acute and chronic illnesses in infants and newborns; To help participants assess their knowledge strength and identify learning gaps to improve patient outcomes; To help participants keep current on new developments and meet their need for continuing professional development using evidence-informed medical information; and To aid neonatolgists and perinatologists in their efforts to prepare for MOC in neonatal/perinatal medicine.

Minimum System Requirements: Windows 98, 2000, XP, or Vista Recommended Browser: Internet Explorer 4.0 or above or Netscape 4.0 or above. The AAP does not support the Safari browser. Recommended Software: Adobe Acrobat Reader 6.0. Click here to download Adobe Acrobat Reader 6.0.

Completion of NeoReviews NeoReviews participants are required to read any one of the two continuing medical education (CME) articles in each issue; each article offers 1 AMA PRA Category 1 Credit. Each CME article is followed by up to 5 quiz questions. Each question represents an incomplete statement or asks a question requiring the selection of the SINGLE BEST ANSWER from five possible choices. A minimum passing score of 60% must be achieved in order to claim credit. The verified references in each article provide an avenue for further study and learning. It is important to note that the NeoReviews Editorial Board, which includes 14 neonatologists, comprises the primary group of subspecialty reviewers. If additional review is deemed necessary, ancillary reviewers are sought by the editor-inchief. Though subscribers occasionally dispute the best answer, the final resolution, as presented in the critiques, represents the Editorial Boards best efforts to provide balanced, up-to-date, evidence-informed information. The point of the questions and their accompanying explanations is not so much to impart final authority as it is to stimulate critical thinking. Thus, at times, the most obvious preferred response may not be listed as an option in the question, although it is discussed in the critique.

The answers and critiques published herein have been checked carefully and represent authoritative opinions about the questions concerned. However, they do not represent the official opinion of the AAP, indicate an exclusive course of treatment, or serve as a standard of medical care.

NeoReviews Faculty and Staff The following people are essential to the design, development and deployment of this online review journal: Faculty Alistair G.S. Philip, MD, FRCPE, FAAP, Editor-in-Chief Emeritus Professor of Pediatrics Division of Neonatal and Developmental Medicine Department of Pediatrics Stanford University School of Medicine Palo Alto, CA Josef Neu, MD, FAAP, Associate Editor Professor, Neonatology Division Department of Pediatrics University of Florida College of Medicine Gainesville, FL Jayant P. Shenai, MD, FAAP, Associate Editor Professor of Pediatrics Director, Educational Affairs Vanderbilt University School of Medicine Nashville, TN Henry C. Lee, MD, MS, FAAP, Assistant Editor Assistant Clinical Professor of Pediatrics

Division of Neonatology Department of Pediatrics University of California, San Francisco San Francisco, CA JoDee M. Anderson, MD, MEd, FAAP, Assistant Editor Assistant Professor Director, Neonatal-Perinatal Fellowship Program Director, Simulation Education Oregon Health and Sciences University Portland, Oregon EDITORIAL BOARD Dara Brodsky, MD Asst. Professor of Pedatrics, Harvard Medical School Associate Diretor, Beth Israel Deaconess Medical Center Boston, MA Robert Castro MD, FAAP Clinical Professor of Pediatrics Division of Neonatal and Developmental Medicine Department of Pediatrics Stanford University School of Medicine Palo Alto, CA Ivan Hand, MD, FAAP Associate Professor of Pediatrics SUNY-Downstate School of Medicine Director of Neonatology

Kings County Hospital Center Brooklyn, NY M. Gary Karlowicz, MD, FAAP Professor of Pediatrics Eastern Virginia Medical School Neonatologist Childrens Hospital of The Kings Daughters Norfolk, VA Jane E. McGowan, MD, FAAP Associate Chair for Research Professor of Pediatrics Section of Neonatology Department of Pediatrics Drexel University College of Medicine Medical Director, NICU St. Christopher's Hospital for Children Philadelphia, PA Steven Ringer, MD, PhD, FAAP Assistant Professor of Pediatrics Harvard Medical School Division of Newborn Medicine Brigham and Women's Hospital Boston, MA Renate Dara Savich, MD, FAAP Professor of Pediatrics

Childrens Hospital of New Mexico Albuquerque, NM Karen Shattuck, MD, FAAP Professor of Pediatrics, Division of Neonatology University of Texas Medical Branch Galveston, TX Susan Townsend, MD, FAAP Clinical Associate Professor of Pediatrics Affiliate Faculty, Center for Bioethics University of Colorado Denver Medical Director, Pediatrix Medical Group Colorado Springs, CO William E. Truog, MD, FAAP Professor and Associate Chair, Department of Pediatrics University of Missouri-Kansas City School of Medicine Sosland Endowed Chair in Neonatal Research Medical Director, Center for Infant Pulmonary Disorders Childrens Mercy Hospitals and Clinics Kansas City, MO John Hartline, Consultant, NeoReviewsPlus Self-Assessment Clinical Professor of Pediatrics & Human Development (Emeritus) Michigan State University College of Human Medicine, East Lansing, Michigan Itasca, IL Carole Kenner, DNS, PhD, RNC-NIC, FAAN, Liaison,

Council of International Neonatal Nurses Inc. Dean/Professor School of Nursing Associate Dean Bouv College of Health Sciences Northeastern University Boston, MA Staff Lani Lucente Demchak, Editorial Assistant Palo Alto, CA AAP Staff Robert Perelman, MD, FAAP AAP Associate Executive Director Director, AAP Department of Education Michael J. Held Director, AAP Division of Medical Journals and Professional Periodicals Susan Piscoran, MT(ASCP), Senior Managing Editor Luann Zanzola, Managing Editor Kathleen Bernard, Editorial Assistant Consultants Christine Crane, HighWire Press, Stanford University Libraries Lorena Hitchens, HighWire Press, Stanford University Libraries

AAP Policy on Disclosure of Financial Relationships and Resolution of Conflicts of Interest for AAP CME Activities Background In order to support the professional needs of its members, the AAP CME program aims to develop, maintain, and improve the competence, skills, and professional performance of pediatricians and pediatric healthcare professionals by providing quality, relevant, accessible, and effective educational experiences that address gaps in professional practice. The AAP CME program strives to meet participants' educational needs and support their life-long learning with a goal of improving care for children and families. (AAP CME Program Mission Statement, September 2010) The AAP recognizes that there are a variety of financial relationships between individuals and commercial interests that require review to identify possible conflicts of interest in a CME activity. This policy is designed to ensure quality, objective, balanced, and scientifically rigorous AAP sponsored or jointly sponsored Continuing Medical Education (CME) activities by identifying and resolving all potential conflicts of interest prior to the confirmation of service of those in a position to influence and/or control CME content. All AAP CME activities will strictly adhere to the Accreditation Council for Continuing Medical Education (ACCME) Standards for Commercial Support: Standards to Ensure the Independence of CME Activities. In accordance with these Standards, the following decisions will be made free of the control of a commercial interest: identification of CME needs, determination of educational objectives, selection and presentation of content, selection of all persons and organizations that will be in a position to control the content, selection of educational methods, and evaluation of the CME activity (ACCME Standard 1.1). The purpose of this policy and its associated procedures is to ensure all potential conflicts of interest are identified and mechanisms to resolve them prior to the CME activity are implemented in ways that are consistent with the public good. Policy The ACCME requires accredited CME providers to identify and resolve all potential conflicts of interest with any individual in a position to influence and/or control the content of CME activities. A conflict of interest will be considered to exist if the individual has received financial benefits in any amount from a commercial interest within the past 12 months AND that individual is in a position to affect the content of CME regarding the products or services of the commercial interest. As a CME provider accredited by the ACCME, the AAP requires all individuals* in a position to influence and/or control the content of AAP directly and jointly sponsored CME activities to disclose to the AAP and subsequently to learners that the individual either has no relevant financial relationships or has any

relevant financial relationships with the manufacturer(s) of any commercial product(s) and/or provider(s) of commercial services discussed in CME activities. Individuals are required to disclose the following information per ACCME Standard 6.1: name of the individual** name of the commercial interest(s)*** nature of the financial relationship the individual has with each commercial interest**** discussion of off label use (per AAP policy)

Disclosure information provided by all those in a position to influence and/or control CME content must never include a trade name or a product-group message (ACCME Standard 6.4). Disclosure information must first be disclosed to AAP staff for determination of potential conflicts of interest. All disclosure information must be provided to AAP CME activity participants prior to the beginning of the CME activity (ACCME Standard 6.5). All potential conflicts of interest identified through the review of AAP Full Disclosure Statement forms must be resolved in order for individuals in a position to influence and/or control CME content to be confirmed for the educational assignment. The resolution process and outcomes must be documented in the CME activity file. Beyond disclosure of financial relationships, AAP CME faculty and authors are required to disclose to the AAP and to learners when they plan to discuss or demonstrate pharmaceuticals and/or medical devices that are not approved by the FDA and/or medical or surgical procedures that involve an unapproved or off-label use of an approved device or pharmaceutical. The AAP requires that the content of directly and jointly sponsored CME activities provide balance, independence, objectivity, and scientific rigor. Planning must be free of the influence or control of a commercial entity, and promote improvements or quality in healthcare. All recommendations in CME activities involving clinical medicine must be based on evidence accepted within the medical profession. The content or format of a CME activity and its related materials must promote improvements or quality in healthcare and not a specific proprietary commercial interest (ACCME Standard 5.1). All AAP CME activities must be compliant with the ACCME content validation statements (ACCME policy 2002-B-09): All the recommendations involving clinical medicine in a CME activity must be based on evidence that is accepted within the profession of medicine as adequate justification for their indications and contraindications in the care of patients.

All scientific research referred to, reported or used in CME in support or justification of a patient care recommendation must conform to the generally accepted standards of experimental design, data collection and analysis.

Providers are not eligible for ACCME accreditation or reaccreditation if they present activities that promote recommendations, treatment or manners of practicing medicine that are not within the definition of CME, or known to have risks or dangers that outweigh the benefits or known to be ineffective in the treatment of patients. Presentations must give a balanced view of therapeutic options. Use of generic names will contribute to this impartiality. If the CME educational material or content includes trade names, trade names from several companies should be used and not just trade names from a single company (ACCME Standard 5.2). Educational materials that are part of a CME activity such as slides, abstracts, and handouts cannot contain any advertising, trade names without generic names (but listing of trade names from several companies is permissible), or product-group advertising (ACCME Standard 4.3).Any individual refusing to comply with the AAP Policy on Disclosure of Financial Relationships and Resolution of Conflicts of Interest for AAP CME Activities and/or not disclosing relevant financial relationships on a timely basis (defined by the Committee on CME as the initial invitation and two reminders) will not participate in, have control of, or responsibility for, the development, management, presentation, or evaluation of AAP CME activities. All AAP CME activities will be evaluated by learners and peer reviewers to determine if the content was free of commercial bias. All those identified as having influence and/or control of CME content perceived as either manifesting conflicts of interest or being biased may be disqualified from consideration as resources (planning group member, authors, faculty, etc) in subsequent CME activities for a time to be determined by the Committee on CME.

_________________________________________________________________________________ *faculty (live and online courses); authors of journal articles, self assessments, enduring materials (e.g. CD ROM, video, etc); CME planning groups/committees; CME editorial boards, AAP Committee on CME, AAP Section/Council program chairs; abstract reviewers; peer reviewers; abstract authors and presenters; staff serving as CME faculty or those directly impacting or managing CME content or activities; spouse/partner **ACCME considers relationships of the person involved in the CME activity to include financial relationships, in any dollar amount, of a spouse or partner.

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***The ACCME defines a commercial interest as any entity producing, marketing, re-selling, or distributing health care goods or services consumed by, or used on, patients. **** The ACCME defines relevant financial relationships as financial relationships in any amount occurring within the past 12 months that create a conflict of interest. Financial relationships are those relationships in which the individual benefits by receiving a salary, royalty, intellectual property rights, consulting fee, honoraria, ownership interest (e.g., stocks, stock options or other ownership interest excluding diversified mutual funds) or other financial benefits. Financial benefits are usually associated with roles such as employment, management position, independent contractor (including contracted research), consulting, speaking and teaching (including Speakers Bureaus), membership on advisory committees or review panels, board membership, and other activities from which remuneration is received or expected. A personal financial relationship does NOT exist when a company contracts with an institution to perform research and the institution then independently employs individuals to work on the institutions project. (September 2010)

Activity Title: NeoReviews 2012 Activity Location: Online journal Activity Dates: Jan. 1, 2012 Dec. 31, 2014

DISCLOSURE OF FINANCIAL RELATIONSHIPS All individuals in a position to influence and/or control the content of AAP CME activities are required to disclose to the AAP and subsequently to learners that the individual either has no relevant financial relationships or any financial relationships with the manufacturer(s) of any commercial product(s) and/or provider of commercial services discussed in CME activities. Commercial interest(s) is defined as any entity producing, marketing, selling or distributing health care goods or services consumed by, or used on, patients.

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NeoReviews Editorial Board 2011-12

Name Relevant Financial Relationship (Please indicate Yes, or No) Name of Commercial Interest(s)* (Please list name(s) of entity) AND Nature of Relevant Financial Relationship(s) (Please list: Research Grant, Speakers Bureau, Stock/Bonds excluding mutual funds, Consultant, Other - identify) Disclosure of Off-Label (Unapproved)/Investigational Uses of Products AAP CME faculty are required to disclose to the AAP and to learners when they plan to discuss or demonstrate pharmaceuticals and/or medical devices that are not approved by the FDA and/or medical or surgical procedures that involve an unapproved or off-label use of an approved device or pharmaceutical. (Do intend to discuss or Do not intend to discuss)

Alistair G.S. Philip, MD, FAAP, Editor-in-Chief Josef Neu, MD, FAAP, Associate Editor Jayant P. Shenai, MD, FAAP, Associate Editor Henry C., Lee, MD, MS, FAAP, Assistant Editor JoDee M. Anderson, MD, MEd, FAAP, Assistant Editor Dara Brodsky, MD, FAAP Robert Castro, MD, FAAP Ivan Hand, MD, FAAP

No

None

Do not intend to discuss

No

Abbott Nutrition, Nestle: consultant. Mead Johnson: research grant, consultant, advisory board. Medela: scientific advisory board. None None None

Do not intend to discuss

No No No

Do not intend to discuss Do not intend to discuss Do not intend to discuss

No No No

None None MedImmune, Abbott Nutrition: speaker bureaus.

Do not intend to discuss Do not intend to discuss Do not intend to discuss

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M. Gary Karlowicz, MD, FAAP Jane E. McGowan, MD, FAAP Steven Ringer, MD, FAAP Renate Dara Savich, MD, FAAP Karen Shattuck, MD, FAAP Susan Townsend, MD, FAAP William E. Truog, MD, FAAP John Hartline, MD, FAAP, Consultant Carole Kenner, DNS, PhD, NANN Liaison
RNC-NIC, FAAN,

No No No

None None None

Do not intend to discuss Do not intend to discuss Do not intend to discuss

No

None

Do not intend to discuss

No

None

Do not intend to discuss

No Yes

None ONY Inc.: pilot clinical research study. National Heart, Blood and Lung Institute (NIH): Trial of Late Surfactant (to Prevent BPD). None None

Do not intend to discuss Do intend to discuss

No No

Do not intend to discuss Do not intend to discuss

Robert Perelman, MD, FAAP Michael Held Susan Piscoran Luann Zanzola Deborah K. Kuhlman Lani Lucente Demchak

No No No No No No

None None None None None None

Do not intend to discuss Do not intend to discuss Do not intend to discuss Do not intend to discuss Do not intend to discuss Do not intend to discuss

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Kathleen Bernard

No

None

Do not intend to discuss

NeoReviews Editorial Board 2010-11

Name Relevant Financial Relationship (Please indicate Yes, or No) Name of Commercial Interest(s)* (Please list name(s) of entity) AND Nature of Relevant Financial Relationship(s) (Please list: Research Grant, Speakers Bureau, Stock/Bonds excluding mutual funds, Consultant, Other - identify) Disclosure of Off-Label (Unapproved)/Investigational Uses of Products AAP CME faculty are required to disclose to the AAP and to learners when they plan to discuss or demonstrate pharmaceuticals and/or medical devices that are not approved by the FDA and/or medical or surgical procedures that involve an unapproved or off-label use of an approved device or pharmaceutical. (Do intend to discuss or Do not intend to discuss)

Alistair G.S. Philip, MD, FAAP, Editor-in-Chief William W. Hay Jr., MD, FAAP, Editor Emeritus Josef Neu, MD, FAAP, Associate Editor Jayant P. Shenai, MD, FAAP, Associate Editor Henry C., Lee, MD, MS, FAAP, Assistant Editor Robert Castro, MD, FAAP

No

None

Do not intend to discuss

No

None

Do not intend to discuss

No

Abbott Nutrition, Nestle: consultant. Mead Johnson: research grant, consultant, advisory board. Medela: scientific advisory board. None None None

Do not intend to discuss

No No No

Do not intend to discuss Do not intend to discuss Do not intend to discuss

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Eric Eichenwald, MD, FAAP (through 12/31/10) Marilyn Escobedo, MD, FAAP Ivan Hand, MD, FAAP M. Gary Karlowicz, MD, FAAP Jane E. McGowan, MD, FAAP Steven Ringer, MD, FAAP Karen Shattuck, MD, FAAP Susan Townsend, MD, FAAP William E. Truog, MD, FAAP John Hartline, MD, FAAP, Consultant Carole Kenner, DNS, PhD, NANN Liaison
RNC-NIC, FAAN,

No

None

Do not intend to discuss

No No No No No

None MedImmune, Abbott Nutrition: speaker bureaus. None None None

Do not intend to discuss Do not intend to discuss Do not intend to discuss Do not intend to discuss Do not intend to discuss

No

None

Do not intend to discuss

No Yes

None ONY Inc.: pilot clinical research study. National Heart, Blood and Lung Institute (NIH): Trial of Late Surfactant (to Prevent BPD). None None

Do not intend to discuss Do intend to discuss

No No

Do not intend to discuss Do not intend to discuss

Robert Perelman, MD, FAAP Michael Held Susan Piscoran

No No No

None None None

Do not intend to discuss Do not intend to discuss Do not intend to discuss

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Luann Zanzola Deborah K. Kuhlman Lani Lucente Demchak Kathleen Bernard

No No No No

None None None None

Do not intend to discuss Do not intend to discuss Do not intend to discuss Do not intend to discuss

Pediatrics in Review 2009-10 Editorial Board

Name Relevant Financial Relationship (Please indicate Yes, or No) Name of Commercial Interest(s)* (Please list name(s) of entity) AND Nature of Relevant Financial Relationship(s) (Please list: Research Grant, Speakers Bureau, Stock/Bonds excluding mutual funds, Consultant, Other - identify) Disclosure of Off-Label (Unapproved)/Investigational Uses of Products AAP CME faculty are required to disclose to the AAP and to learners when they plan to discuss or demonstrate pharmaceuticals and/or medical devices that are not approved by the FDA and/or medical or surgical procedures that involve an unapproved or off-label use of an approved device or pharmaceutical. (Do intend to discuss or Do not intend to discuss)

Lawrence F. Nazarian, MD, FAAP, Editor Tina L. Cheng, MD, MPH, FAAP, Associate Editor Joseph A. Zenel, MD, FAAP, Associate Editor Robert J. Haggerty, MD, FAAP, Editor Emeritus and Founding Editor Henry M. Adam, MD, FAAP, Editor, In Brief Deepak Kamat, MD, FAAP, Editor, Index of Suspicion

No No

None National Institutes of Health, US Centers for Disease Control, Office of Adolescent Pregnancy Program, various foundations Research grants None None

Do intend to discuss but will identify offlabel use. Do not intend to discuss.

No No

Do not intend to discuss. Do not intend to discuss.

No No

None None

Do not intend to discuss. Do not intend to discuss.

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Janet Serwint, MD, FAAP, Consulting Editor Laura Ibsen, MD, FAAP, Consulting Editor, Online and Multimedia Projects Hugh D. Allen, MD, FAAP Margie Andreae, MD, FAAP Richard Antaya, MD, FAAP

No

None

Do not intend to discuss.

No

None

Do not intend to discuss.

No No Yes

None None Astellas Pharma, US, Inc. speaker bureau, advisory boards, clinical trials; Novartis speaker bureau

Do intend to discuss. Do not intend to discuss. Do intend to discuss.

Denise Bratcher, DO, FAAP George R. Buchanan, MD, FAAP Brian Carter, MD, FAAP Latha Chandran, MD, FAAP David N. Cornfield, MD, FAAP Joseph Croffie, MD, FAAP

No No

None None

Do not intend to discuss. Do not intend to discuss.

No No Yes

None None Sucampo Pharmaceuticals (Lubiprostone), Braintree Lbs (Miralax, Halfytely), Medtronics (Bravo pH Capsule), Tap pharmaceuticals (Prevacid) research grant, speaker bureau

Do not intend to discuss. Do not intend to discuss. Do not intend to discuss.

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B. Anne Eberhard, MD BS, MSc, FAAP Leonard Feld, MD, PhD, MMM, FAAP Rani Gereige, MD, MPH, FAAP Mark Goldstein, MD, FAAP Lindsey Grossman, MD, FAAP Patricia Hamilton, MD Hal B. Jenson, MD, FAAP Donald Wray Lewis, MD, FAAP

No No

None None; speaker and committee member of a Pediatric Board Review Course (sponsored by Abbott Nutrition) though AAP New York None None None None None Astra Zeneca, Merck Research grant, consultant; Ortho McNeil, Lilly, Bristol-Myers Squibb, GlaxoSmithKline, Boehringer Ingelheim Pharmaceutical research grants None None None None None

Do not intend to discuss. Do intend to discuss.

No No No No Yes Yes

Do not intend to discuss. Do not intend to discuss. Do not intend to discuss. Do not intend to discuss. Do intend to discuss. N/A

Gregory S. Liptak, MD, MPH, FAAP Blaise Nemeth, MD, MS, FAAP John Pascoe, MD, MPH, FAAP Thomas T. Sato, MD, FACS, FAAP Nancy D. Spector, MD, FAAP

No No No No No

Do not intend to discuss. Do not intend to discuss. Do not intend to discuss. Do not intend to discuss. Do not intend to discuss.

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Surendra K. Varma, MD, FAAP

No

None

Do not intend to discuss.

Continuing Medical Education Credit The American Academy of Pediatrics (AAP) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. AAP designates this journal-based CME activity for a maximum of 24 AMA PRA Category 1 Credit(s). Physicians should claim only credit commensurate with the extent of their participation in the activity. This activity is acceptable for a maximum of 24 AAP credits. These credits can be applied toward the AAP CME/CPD* Award available to Fellows and Candidate Members of the AAP. The American Academy of Physician Assistants accepts AMA PRA Category 1 Credit(s)TM from organizations accredited by the ACCME. This program is approved for 24 NAPNAP CE contact hours; pharmacology (Rx) contact hours to be determined per the National Association of Pediatric Nurse Practitioners Continuing Education Guidelines. It has been established that each months questions will take the learner at least 2 hours complete. *Continuing Professional Development Claiming CME credit Activity Title: NeoReviews 2012 Activity Location: Online Journal Activity Dates: Jan. 1, 2012 Dec. 31, 2014 NeoReviews subscribers may claim a maximum of 24 AMA PRA Category 1 Credit(s)TM upon completion of all the NeoReviews quiz questions over the course of their annual subscription. On a monthly basis members may claim a maximum of 2 AMA PRA Category 1 Credit(s).TM

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New Minimum Performance Level: requirements: Per the 2010 revision of the American Medical Association (AMA) Physicians Recognition Award (PRA) and credit system, a minimum performance level must be established on enduring material and journal-based CME activities that are certified for AMA PRA Category 1 Credit. In order to successfully complete NeoReviews for AMA PRA Category 1 Credit, learners must demonstrate a minimum performance level of 60% or higher on the quiz, which measures achievement of the educational purpose and/or objectives of the activity. Starting with 2012 NeoReviews, AMA PRA Category 1 Credit can be claimed only if 60% or more of the questions are answered correctly. If a learner scores less than 60% on the assessment, s/he will be given additional opportunities to answer questions until an overall 60% or greater score is achieved. Once the minimum score has been achieved, members are provided with a link to their Transcript on pedialink.org to claim CME credit each time they answer all the questions for a subscription month. If you are not an AAP member or a PediaLink subscriber, please request a certificate of completion via e-mail to transcripts@aap.org. Include your first and last name, your AAP ID number, the title of the activity, and the date you completed the activity. Please allow 15 20 business days for your certificate to be processed. No product-specific advertising of any type, or links to product web sites, appear in this educational activity. Acknowledgments The American Academy of Pediatrics (AAP) gratefully acknowledges the contributions to the development and production of the 2012 NeoReviews of the following individuals: Christine Crane (HighWire Press project manager), Lorena Hitchens, HighWire Press CME manager), and Lani Lucente Demchak (Editorial Assistant).

Questions or Comments If you have a question, suggestion, or comment about NeoReviews, please contact the AAP Customer Service Center at: Phone: Email: 866-843-2271 csc@aap.org

Address Changes

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Contact the AAP Customer Service Center at 1-866-843-2271, Monday through Friday, 7 AM - 5:30 PM Central Time, or e-mail csc@aap.org at anytime. AAP members can edit contact information by logging on to www.aap.org/moc and clicking on Update My Personal Profile. Be sure to provide your AAP ID number on any correspondence. Or mail your request to: American Academy of Pediatrics Customer Service Center 141 Northwest Point Blvd. Elk Grove Village, IL 60007-1098

Technical Support For technical support, please submit your request via the NeoReviews Feedback website http://neoreviews.aappublications.org/cgi/feedback You should receive an emailed response within 1-2 business days. If you prefer, you may contact the AAP at 866-THE-AAP1 (843-2271) or csc@aap.org. To order products, visit the AAP on the web at http://www.aap.org.

AAP Privacy Statement The American Academy of Pediatrics (AAP) takes the issue of privacy very seriously. This policy is intended to help you understand how AAP collects, uses and safeguards the information collected on our Web site. This Privacy Policy does not apply to the use or disclosure of information that is collected or obtained through means other than this Web site. Collection of Information: Visitors may generally browse public portions of the AAP Web site anonymously without providing any personal information. However, AAP members are required to provide personal information in connection with registering for or accessing member portions of the site. In addition, personal information will be requested in connection with purchasing products or services, requesting additional information, signing up for newsletters or listservs, participating in forums or submitting questions through this site. In general, a visitor will know when personal information is being collected because he or she will have to fill out a form. AAP does not knowingly collect or use any personal information from users under 13 years of age. AAP will endeavor to correct, update or remove collected personal data if contacted (webmaster@aap.org). AAP Use of Information: Any information collected on the Web site will be used by the AAP only for the purpose stated at the time of collection. Only those who ask to be added to AAP e-mail lists or who ask for information from AAP will receive e-mail communications from AAP. AAP members may be automatically

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added to AAP e-mail lists or certain other private lists if AAP has an e-mail address for the member. E-mail addresses may be removed from AAP e-mail lists at any time by following the applicable opt-out procedure specified in the list welcome message or by contacting the AAP Listmaster and specifying the name of the list. AAP may share statistical or aggregated, non-personal information about our visitors with affiliates, business partners and other third parties. This data is used for administrative purposes only. Sharing of Information: AAP may provide personal information to third party agents that have been hired to help provide a requested good or service. For example, in connection with a product order, AAP would need to provide the collected credit card number to a payment authorization service and the corresponding address to a shipping company to deliver the package. Unless directed otherwise at the time of collection, AAP may also share collected personal information with third parties who may have information or services that AAP believes could be helpful to members or visitors. AAP may also share personally identifiable information obtained from an AAP member for the purpose of facilitating the member's access to programs and activities consistent with AAP's goal of improving quality in the delivery of pediatric health care services. AAP members may change their preference for the sharing of information on the member page. Other visitors may also opt-out from the sharing of collected information by contacting the AAP Webmaster (webmaster@aap.org). Cookies and Tracking Information: AAP may use "cookie" technology to obtain non-personal information from its on-line visitors. AAP servers may also collect the IP addresses and domain names of visitors for site administration purposes. AAP does not extract personal information in these processes, nor does AAP provide this information to third parties. AAP does not contact on-line visitors based on information in the AAP cookie file. AAP has taken commercially reasonable steps to protect information received from online visitors against unauthorized access and use. All information is protected by AAP security measures, which are periodically reviewed. AAP reserves the right to disclose without notice to the user any information in its possession if required to do so by law, to protect or defend AAP's rights or property, or to respond to an emergency. This Web site contains links to third-party Web sites which are not under the control of the AAP. AAP is not responsible for the privacy practices of any linked site. AAP reserves the right to revise this privacy statement at any time by posting a revised statement on this Web site. Use of this Web site after such change signifies the user's acceptance of the changed terms. Specific areas or pages of this Web site may include additional or different terms relating to the use of personal information collected from such areas or pages and, in the context presented, in the event of any conflict between those specific terms and this Privacy Statement, those specific terms shall control.

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This Privacy Statement is effective as of October 21, 2005. Questions about this privacy policy or requests concerning AAP privacy practices should be directed to the AAP Webmaster (webmaster@aap.org).

2012 by the American Academy of Pediatrics, NeoReviews.

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