Homo sapiens v-rel reticuloendotheliosis viral oncogene homolog (avian) (REL), mRNA

NCBI Reference Sequence: NM_002908.2 FASTA Graphics

nuccore 1 genbank

Comment Features Sequence

NM_002908 2592 bp mRNA linear PRI 19-NOV-

LOCUS 2011 DEFINITION ACCESSION VERSION KEYWORDS SOURCE ORGANISM

REFERENCE AUTHORS Yamaoka,S., TITLE kinase cells JOURNAL PUBMED REMARK transformed

Homo sapiens v-rel reticuloendotheliosis viral oncogene homolog (avian) (REL), mRNA. NM_002908 NM_002908.2 GI:56550118 . Homo sapiens (human) Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. 1 (bases 1 to 2592) Refaat,A., Zhou,Y., Suzuki,S., Takasaki,I., Koizumi,K., Tabuchi,Y., Saiki,I. and Sakurai,H. Distinct roles of transforming growth factor-beta-activated 1 (TAK1)-c-Rel and interferon regulatory factor 4 (IRF4) pathways in human T cell lymphotropic virus 1-transformed T helper 17 producing interleukin-9 J. Biol. Chem. 286 (24), 21092-21099 (2011) 21498517 GeneRIF: TAK1-c-Rel and IRF4 pathways play distinct roles in the maintenance of IL-9-producing Th17 phenotype of HTLV-1-

cells REFERENCE 2 (bases 1 to 2592) AUTHORS Janse,M., Lamberts,L.E., Franke,L., Raychaudhuri,S., Ellinghaus,E., Muri Boberg,K., Melum,E., Folseraas,T., Schrumpf,E., Bergquist,A., Bjornsson,E., Fu,J., Jan Westra,H., Groen,H.J., Fehrmann,R.S., Smolonska,J., van den Berg,L.H., Ophoff,R.A., Porte,R.J., Weismuller,T.J., Wedemeyer,J., Schramm,C., Sterneck,M., Gunther,R., Braun,F., Vermeire,S., Henckaerts,L., Wijmenga,C., Ponsioen,C.Y.,

TITLE JOURNAL PUBMED REMARK role REFERENCE AUTHORS TITLE inhibition JOURNAL PUBMED REMARK of REFERENCE AUTHORS TITLE JOURNAL PUBMED REMARK REFERENCE AUTHORS TITLE JOURNAL PUBMED REMARK REFERENCE AUTHORS Jr. TITLE JOURNAL PUBMED REFERENCE AUTHORS TITLE of JOURNAL

Schreiber,S., Karlsen,T.H., Franke,A. and Weersma,R.K. Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9 Hepatology 53 (6), 1977-1985 (2011) 21425313 GeneRIF: Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a for IL2, REL, and CARD9. 3 (bases 1 to 2592) Alvarez,Y., Municio,C., Hugo,E., Zhu,J., Alonso,S., Hu,X., Fernandez,N. and Sanchez Crespo,M. Notch- and transducin-like enhancer of split (TLE)-dependent histone deacetylation explain interleukin 12 (IL-12) p70 by zymosan J. Biol. Chem. 286 (19), 16583-16595 (2011) 21402701 GeneRIF: IL-23 induction by beta-glucans is due to activation of c-Rel associated with Ser-10-histone H3 phosphorylation in the il23a promoter mediated by MAPK and SAPK or PKA, and inhibition il12a transcription 4 (bases 1 to 2592) Loizou,L., Andersen,K.G. and Betz,A.G. Foxp3 interacts with c-Rel to mediate NF-kappaB repression PLoS ONE 6 (4), E18670 (2011) 21490927 GeneRIF: Data show that Foxp3 directly or as part of a multimeric complex engages with the NF-kappaB component c-Rel. Publication Status: Online-Only 5 (bases 1 to 2592) Gringhuis,S.I., Wevers,B.A., Kaptein,T.M., van Capel,T.M., Theelen,B., Boekhout,T., de Jong,E.C. and Geijtenbeek,T.B. Selective C-Rel activation via Malt1 controls anti-fungal T(H)-17 immunity by dectin-1 and dectin-2 PLoS Pathog. 7 (1), E1001259 (2011) 21283787 GeneRIF: Thus, dectin-1 and dectin-2 control adaptive T(H)-17 immunity to fungi via Malt1-dependent activation of c-Rel. Publication Status: Online-Only 6 (bases 1 to 2592) Neumann,M., Tsapos,K., Scheppler,J.A., Ross,J. and Franza,B.R. Identification of complex formation between two intracellular tyrosine kinase substrates: human c-Rel and the p105 precursor of p50 NF-kappa B Oncogene 7 (11), 2095-2104 (1992) 1437141 7 (bases 1 to 2592) Kunsch,C., Ruben,S.M. and Rosen,C.A. Selection of optimal kappa B/Rel DNA-binding motifs: interaction both subunits of NF-kappa B with DNA is required for transcriptional activation Mol. Cell. Biol. 12 (10), 4412-4421 (1992)

PUBMED REFERENCE AUTHORS TITLE the JOURNAL PUBMED REFERENCE AUTHORS TITLE JOURNAL PUBMED REFERENCE AUTHORS TITLE JOURNAL PUBMED COMMENT

1406630 8 (bases 1 to 2592) Kumar,S., Rabson,A.B. and Gelinas,C. The RxxRxRxxC motif conserved in all Rel/kappa B proteins is essential for the DNA-binding activity and redox regulation of v-Rel oncoprotein Mol. Cell. Biol. 12 (7), 3094-3106 (1992) 1620118 9 (bases 1 to 2592) Ruben,S.M., Klement,J.F., Coleman,T.A., Maher,M., Chen,C.H. and Rosen,C.A. I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity Genes Dev. 6 (5), 745-760 (1992) 1577270 10 (bases 1 to 2592) Kochel,T. and Rice,N.R. v-rel- and c-rel-protein complexes bind to the NF-kappa B site in vitro Oncogene 7 (3), 567-572 (1992) 1549370 VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CN414487.1, X75042.1, BX111941.1 and AA279919.1. On Dec 10, 2004 this sequence version replaced gi:4506472. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the

Gene record to access additional publications. Summary: The REL gene encodes c-Rel, a transcription factor that is a member of the Rel/NFKB family, which also includes RELA (MIM 164014), RELB (604758), NFKB1 (MIM 164011), and NFKB2 (MIM 164012). These proteins are related through a highly conserved N-terminal region termed the 'Rel domain,' which is responsible for DNA binding, dimerization, nuclear localization, and binding to the NFKB inhibitor (MIM 164008) (Belguise and Sonenshein, 2007 [PubMed 18037997]).[supplied by OMIM, May 2008]. REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN 1-174 CN414487.1 2-175 175-2323 X75042.1 128-2276 2324-2457 BX111941.1 575-708 2458-2592 AA279919.1 1-135 FEATURES Location/Qualifiers source 1..2592 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="2" /map="2p13-p12" gene 1..2592 /gene="REL" PRIMARY COMP

/gene_synonym="C-Rel" /note="v-rel reticuloendotheliosis viral oncogene homolog (avian)" /db_xref="GeneID:5966" /db_xref="HGNC:9954" /db_xref="HPRD:01286" /db_xref="MIM:164910" 1..234 /gene="REL" /gene_synonym="C-Rel" /inference="alignment:Splign" /number=1 156..158 /gene="REL" /gene_synonym="C-Rel" /note="upstream in-frame stop codon" 225..2084 /gene="REL" /gene_synonym="C-Rel" /note="v-rel avian reticuloendotheliosis viral oncogene homolog; oncogene REL, avian reticuloendotheliosis; Cproto-oncogene protein" /codon_start=1 /product="proto-oncogene c-Rel" /protein_id="NP_002899.1" /db_xref="GI:4506473" /db_xref="CCDS:CCDS1864.1" /db_xref="GeneID:5966" /db_xref="HGNC:9954" /db_xref="HPRD:01286" /db_xref="MIM:164910" /translation="MASGAYNPYIEIIEQPRQRGMRFRYKCEGRSAGSIPGEHSTDNN RTYPSIQIMNYYGKGKVRITLVTKNDPYKPHPHDLVGKDCRDGYYEAEFGQERRPLFF QNLGIRCVKKKEVKEAIITRIKAGINPFNVPEKQLNDIEDCDLNVVRLCFQVFLPDEH GNLTTALPPVVSNPIYDNRAPNTAELRICRVNKNCGSVRGGDEIFLLCDKVQKDDIEV RFVLNDWEAKGIFSQADVHRQVAIVFKTPPYCKAITEPVTVKMQLRRPSDQEVSESMD FRYLPDEKDTYGNKAKKQKTTLLFQKLCQDHVETGFRHVDQDGLELLTSGDPPTLASQ SAGITVNFPERPRPGLLGSIGEGRYFKKEPNLFSHDAVVREMPTGVSSQAESYYPSPG PISSGLSHHASMAPLPSSSWSSVAHPTPRSGNTNPLSSFSTRTLPSNSQGIPPFLRIP VGNDLNASNACIYNNADDIVGMEASSMPSADLYGISDPNMLSNCSVNMMTTSSDSMGE TDNPRLLSMNLENPSCNSVLDPRDLRQLHQMSSSSMSAGANSNTTVFVSQSDAFEGSD FSCADNSMINESGPSNSTNPNSHGFVQDSQYSGIGSMQNEQLSDSFPYEFFQV" misc_feature 246..1115 /gene="REL" /gene_synonym="C-Rel"

exon

misc_feature

CDS

Rel

/experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q04864.1); Region: RHD" 1092..1109 /gene="REL" /gene_synonym="C-Rel" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q04864.1); Region: Nuclear localization signal (Potential)" 1731..1733 /gene="REL" /gene_synonym="C-Rel" /experiment="experimental evidence, no additional recorded" /note="Phosphoserine; propagated from UniProtKB/SwissProt exon (Q04864.1); phosphorylation site" 235..377 /gene="REL" /gene_synonym="C-Rel" /inference="alignment:Splign" /number=2 378..526 /gene="REL" /gene_synonym="C-Rel" /inference="alignment:Splign" /number=3 527..618 /gene="REL" /gene_synonym="C-Rel" /inference="alignment:Splign" /number=4 619..759 /gene="REL" /gene_synonym="C-Rel" /inference="alignment:Splign" /number=5 760..864 /gene="REL" /gene_synonym="C-Rel" /inference="alignment:Splign" /number=6 865..1077 /gene="REL" /gene_synonym="C-Rel" /inference="alignment:Splign" /number=7 870..1042 /gene="REL" /gene_synonym="C-Rel" /standard_name="Rel" /db_xref="UniSTS:144337" 1078..1146

misc_feature

misc_feature

details

exon

exon

exon

exon

exon

STS

exon

exon

exon

exon

STS

STS

/gene="REL" /gene_synonym="C-Rel" /inference="alignment:Splign" /number=8 1147..1242 /gene="REL" /gene_synonym="C-Rel" /inference="alignment:Splign" /number=9 1243..1311 /gene="REL" /gene_synonym="C-Rel" /inference="alignment:Splign" /number=10 1312..2592 /gene="REL" /gene_synonym="C-Rel" /inference="alignment:Splign" /number=11 2098..2307 /gene="REL" /gene_synonym="C-Rel" /standard_name="SHGC-35444" /db_xref="UniSTS:5840" 2131..2281 /gene="REL" /gene_synonym="C-Rel" /standard_name="RH70902" /db_xref="UniSTS:71477" ggtggacggc ccgcaaaccc gggccccgcc aggacgctgg ataacccgta aatgtgaagg catacccttc taacaaagaa acggctacta gtattcgatg gaatcaatcc atgtggtgag ctcttcctcc taaggatttg tactttgtga aagcaaaagg ctccaccata cttctgacca cttacggcaa atcacgtaga gtgatccacc caagacctgg tgttttctca cctactatcc ctctgccttc acccactgag tcctgagaat gacgctgggt agcggagggc ggcagaggtc gagctgcctg tatagagata gcgatcagca tatccagatt tgacccatat tgaagcagaa tgtgaagaaa attcaatgtc actgtgtttt tgttgtctcg tcgtgtaaac caaagttcag catcttttca ttgcaaagct ggaagttagt taaagcaaag aacagggttt caccttggcc tctcctcggt tgatgcagtt ctcacctggg ttcaagctgg tagtttttca acctgttggg gacccggggt gggaagaagg cctcggcctc cgggaaggtg attgaacaac ggcagcattc atgaactatt aaacctcatc tttggacaag aaagaagtaa cctgaaaaac caagtttttc aacccaattt aagaattgtg aaagatgaca caagctgatg atcacagaac gaatctatgg aaacaaaaga cgccatgttg tcccaaagtg tcaattggag gtgagagaaa cccatctcaa tcatcagtgg acaaggacac aatgatttaa gcaagaattc aggaggcctc ctgactgact cggggagcgg ccaggcagag caggggagca atggaaaagg ctcatgattt aacgcagacc aagaagctat agctgaatga tccctgatga atgacaaccg gaagtgtcag tagaagttcg tacaccgtca ccgtaacagt attttagata caactctgct accaggatgg ctgggattac aaggaagata tgcctacagg gtggattgtc cccaccccac ttccttctaa atgcttctaa aggggttggg tagggtggtc gactgcggcc agccatggcc gggaatgcgt cagcacagac aaaagtgaga agttggaaaa tttgtttttc tattacaaga tattgaagat acatggtaat tgctccaaat aggaggagat ttttgtgttg agtagccatt aaaaatgcag tctgccagat tttccagaaa tcttgaactc agttaatttt cttcaaaaaa ggtttcaagt acatcatgcc cccacgctca ttcgcaaggt tgcttgcatt aaggtgtgag gggggactgg gcctccggcc tccggtgcgt tttagataca aacaaccgaa attacattag gactgcagag caaaatttgg ataaaggcag tgtgacctca ttgacgactg actgcagaat gaaatatttc aacgattggg gttttcaaaa ttgcggagac gaaaaagata ctgtgccagg ctgacatcag cctgagagac gaaccaaact caagcagaat tcaatggcac ggcaatacaa atcccaccat tacaacaatg

ORIGIN 1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 1021 1081 1141 1201 1261 1321 1381 1441 1501 1561

1621 1681 1741 1801 1861 1921 1981 2041 2101 2161 2221 2281 2341 2401 2461 2521 2581 //

ccgatgacat ctgatcccaa tgggagagac cagtgttaga caggcgccaa acttcagttg caaacagtca agcaattgag ccttttaaat tataatacta gaatataaaa ttggaagctg ctagcacttt tggccaacat tacgtgcctg aagcagaggt agactctgtc

agtcggaatg catgctgtct tgataatcca cccaagagac ttccaatact tgcagataac tggttttgtt tgactccttt cttgatacca tatttatact aacttttttc tcataaaaag gggaggccaa ggtgaaaccc tactgtcagc tgcagtgagc tc

gaagcgtcat aattgttctg agacttctga ttgagacagc actgtttttg agcatgataa caagatagtc ccatatgaat cctatataga gtatatataa agggaagaag acaactcaga ggcgggtgga cgtctctact tacttgggag tgagatcaca

ccatgccatc tgaatatgat gcatgaatct tccatcagat tttcacaatc atgagtcggg agtattcagg tttttcaagt tgcagcattt tactgactga catacaactt ggccaggcgc tcacttgaga aaaaatacaa gctgaggcac ccaccgcact

agcagattta gacaaccagc tgaaaacccc gtcctcttcc agatgcattt accatcaaac tattggcagt ataacttgca tgtatttgtc gaatataata tggacatagc aggggctcac ccaggaattc aaattagctg aataattgtt ccagcctggg

tatggtattt agtgacagca tcatgtaatt agtatgtcag gagggatctg agtactaatc atgcaaaatg agatttaaat taactgggga ctgtatttga gaatacaaaa acctgtaatc gagaccagcc agcatggtgg tgaacccagg tgacagagtg