28/11/2018 actin, cytoplasmic 1 [Gallus gallus] - Protein - NCBI

Protein

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actin, cytoplasmic 1 [Gallus gallus]

NCBI Reference Sequence: NP_990849.1
Identical Proteins FASTA Graphics

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LOCUS NP_990849 375 aa linear VRT 20-OCT-2018

DEFINITION actin, cytoplasmic 1 [Gallus gallus].
ACCESSION NP_990849 XP_429312
VERSION NP_990849.1
DBSOURCE REFSEQ: accession NM_205518.1
KEYWORDS RefSeq.
SOURCE Gallus gallus (chicken)
ORGANISM Gallus gallus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
REFERENCE 1 (residues 1 to 375)
AUTHORS Lin J and Redies C.
TITLE Histological evidence: housekeeping genes beta-actin and GAPDH are
of limited value for normalization of gene expression
JOURNAL Dev. Genes Evol. 222 (6), 369-376 (2012)
PUBMED 23099774
REMARK GeneRIF: Results show that despite being commonly used housekeeping
genes neither GAPDH mRNA nor beta-actin mRNA is expressed in all
cell types or tissues at high levels. Strikingly, expression levels
are very low in some organs.
REFERENCE 2 (residues 1 to 375)
AUTHORS Dolge L, Aufenvenne K, Traupe H and Baumgartner W.
TITLE Beta-actin is a target for transglutaminase activity at synaptic
endings in chicken telencephalic cell cultures
JOURNAL J. Mol. Neurosci. 46 (2), 410-419 (2012)
PUBMED 21789544
REMARK GeneRIF: beta-actin is a substrate for native chick
telencephalon-cell transglutaminase 1 and recombinant human TGM1 in
vitro. TGM1 stabilizes the actin cytoskeleton by cross-linking.
REFERENCE 3 (residues 1 to 375)
AUTHORS Harpen M, Barik T, Musiyenko A and Barik S.
TITLE Mutational analysis reveals a noncontractile but interactive role
of actin and profilin in viral RNA-dependent RNA synthesis
JOURNAL J. Virol. 83 (21), 10869-10876 (2009)
PUBMED 19710142
REMARK GeneRIF: Results suggest that actin acts as a classical
transcription factor for the virus by divalent-cation-dependent
binding to the viral template and that profilin acts as a
transcriptional cofactor, in part by associating with actin.
REFERENCE 4 (residues 1 to 375)
AUTHORS Caldwell RB, Kierzek AM, Arakawa H, Bezzubov Y, Zaim J, Fiedler P,
Kutter S, Blagodatski A, Kostovska D, Koter M, Plachy J, Carninci
P, Hayashizaki Y and Buerstedde JM.
TITLE Full-length cDNAs from chicken bursal lymphocytes to facilitate
gene function analysis
JOURNAL Genome Biol. 6 (1), R6 (2005)
PUBMED 15642098
REFERENCE 5 (residues 1 to 375)
AUTHORS Nakajima Y, Yamagishi T, Yoshimura K, Nomura M and Nakamura H.
TITLE Antisense oligodeoxynucleotide complementary to smooth muscle
alpha-actin inhibits endothelial-mesenchymal transformation during
chick cardiogenesis
JOURNAL Dev. Dyn. 216 (4-5), 489-498 (1999)
PUBMED 10633868
REFERENCE 6 (residues 1 to 375)
AUTHORS Fukata M, Kuroda S, Fujii K, Nakamura T, Shoji I, Matsuura Y, Okawa
K, Iwamatsu A, Kikuchi A and Kaibuchi K.
TITLE Regulation of cross-linking of actin filament by IQGAP1, a target
for Cdc42
JOURNAL J. Biol. Chem. 272 (47), 29579-29583 (1997)
PUBMED 9368021
REFERENCE 7 (residues 1 to 375)
AUTHORS North AJ, Gimona M, Lando Z and Small JV.
TITLE Actin isoform compartments in chicken gizzard smooth muscle cells
JOURNAL J. Cell. Sci. 107 (Pt 3), 445-455 (1994)
PUBMED 8006065
REFERENCE 8 (residues 1 to 375)
AUTHORS Paterson,B.M. and Eldridge,J.D.
TITLE alpha-Cardiac actin is the major sarcomeric isoform expressed in
embryonic avian skeletal muscle
JOURNAL Science 224 (4656), 1436-1438 (1984)
PUBMED 6729461
REFERENCE 9 (residues 1 to 375)

https://www.ncbi.nlm.nih.gov/protein/NP_990849.1 1/2
28/11/2018 actin, cytoplasmic 1 [Gallus gallus] - Protein - NCBI
AUTHORS Kost,T.A., Theodorakis,N. and Hughes,S.H.
TITLE The nucleotide sequence of the chick cytoplasmic beta-actin gene
JOURNAL Nucleic Acids Res. 11 (23), 8287-8301 (1983)
PUBMED 6324080
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from L08165.1.
On Aug 30, 2004 this sequence version replaced XP_429312.1.

##Evidence-Data-START##
Transcript exon combination :: L08165.1, CV862290.1 [ECO:0000332]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..375
/organism="Gallus gallus"
/db_xref="taxon:9031"
/chromosome="14"
/map="14"
/breed="Leghorn"
Protein 1..375
/product="actin, cytoplasmic 1"
/note="beta-actin; cytoplasmic 1; Bact; actin"
/calculated_mol_wt=41606
Region 1..375
/region_name="PTZ00281"
/note="actin; Provisional"
/db_xref="CDD:173506"
Site 1
/site_type="other"
/experiment="experimental evidence, no additional details
recorded"
/note="N-acetylmethionine, in Actin, cytoplasmic 1,
alternate. {ECO:0000250}; propagated from
UniProtKB/Swiss-Prot (P60706.1)"
Site 2
/site_type="other"
/experiment="experimental evidence, no additional details
recorded"
/note="N-acetylaspartate, in Actin, cytoplasmic 1,
N-terminally processed. {ECO:0000269|Ref.3}; propagated
from UniProtKB/Swiss-Prot (P60706.1)"
Site order(11..14,16,18,137,154..157)
/site_type="other"
/note="nucleotide binding site [chemical binding]"
/db_xref="CDD:212657"
Site 44
/site_type="sulfatation"
/experiment="experimental evidence, no additional details
recorded"
/note="Methionine (R)-sulfoxide.
{ECO:0000250|UniProtKB:P60710}; propagated from
UniProtKB/Swiss-Prot (P60706.1)"
Site 47
/site_type="sulfatation"
/experiment="experimental evidence, no additional details
recorded"
/note="Methionine (R)-sulfoxide.
{ECO:0000250|UniProtKB:P60710}; propagated from
UniProtKB/Swiss-Prot (P60706.1)"
Site 73
/site_type="other"
/experiment="experimental evidence, no additional details
recorded"
/note="Tele-methylhistidine.
{ECO:0000250|UniProtKB:P60710}; propagated from
UniProtKB/Swiss-Prot (P60706.1)"
CDS 1..375
/gene="ACTB"
/gene_synonym="actin; Bact"
/coded_by="NM_205518.1:69..1196"
/db_xref="CGNC:49855"
/db_xref="GeneID:396526"
ORIGIN
1 mdddiaalvv dngsgmckag fagddaprav fpsivgrprh qgvmvgmgqk dsyvgdeaqs
61 krgiltlkyp iehgivtnwd dmekiwhhtf ynelrvapee hpvllteapl npkanrekmt
121 qimfetfntp amyvaiqavl slyasgrttg ivmdsgdgvt htvpiyegya lphailrldl
181 agrdltdylm kiltergysf tttaereivr dikeklcyva ldfeqemata assssleksy
241 elpdgqviti gnerfrcpea lfqpsflgme scgihettfn simkcdvdir kdlyantvls
301 ggttmypgia drmqkeital apstmkikii apperkysvw iggsilasls tfqqmwiskq
361 eydesgpsiv hrkcf
//

https://www.ncbi.nlm.nih.gov/protein/NP_990849.1 2/2