y Dyspnea- difficulty breathing y Malaise-general feeling of discomfort y Palpitations-unpleasant sensations of irregular and/or forceful beating of the heart.

y Arrhythmias- heartbeats that are too slow, too rapid, irregular, or too early. y Tachycardia s-Rapid arrhythmias (greater than 100 beats per minute) y Bradycardias- Slow arrhythmias (slower than 60 beats per minute) y Bilious emesis- vomit coming from small intestine y Prader-Willi syndrome- is disease that is present from birth. People with this condition are obese, have reduced muscle tone and mental ability, and have sex glands that produce little or no hormones. A gene missing on part of chromosome 15 causes Prader-Willi syndrome. Most patients with Prader-Willi syndrome are missing the genetic material on part of the father's chromosome and often have two copies of the mother's chromosome 15.The genetic changes occur randomly. y Symptoms- Newborns are small for gestational age, genitals are not well developed (in boys testicles can t be felt in the scrotum), they have problems sucking and swallowing and often don t gain wait, and may seem floppy and feel like a rag dog when held with weak cry also. y Signs and tests- Newborns with the condition are often small and very floppy. Male infants may have undescended testicles. As the child grows older, laboratory tests may show signs of morbid obesity, such as abnormal glucose tolerance, above normal level of hormone insulin in the blood. Failure to respond to luteinizing hormone releasing factors, high carbon dioxide levels and lack of oxygen. y Treatment- Infants may need a feeding tube to help with weight gain. Limiting calories will control the obesity. Exercise can increase lean body mass in children with Prader-Willi syndrome. Growth hormone has also been shown to improve physical strength and agility in patients with Prader-Willi syndrome. A very small penis in the male infant may be corrected with

testosterone. Low levels of sex hormones may be corrected at puberty with hormone replacement. y Angelman syndrome- genetic disorder with characteristic features that include severe speech impairment, developmental delay, intellectual disability, and ataxia (problems with movement and balance). y Symptoms- Most children with Angelman syndrome have microcephaly (small head size) and epilepsy (recurrent seizures) usually around the age of 2-3 they start. The developmental delay of Angelman syndrome generally becomes noticeable by the age of 6 to 12 months. Some of the characteristic features of Angelman syndrome are a result from the loss of function of a gene called UBE3A. y Treatment- There is no specific therapy for Angelman syndrome. Medical therapy for seizures is usually necessary. Physical and occupational therapies, communication therapy, and behavioral therapies are important in allowing individuals with Angelman syndrome to reach their maximum developmental potential.