Endocrine System - Thyroid Disorders PARAMETER

Pathophysiology & Cause of Disorder

Hyperthyroidism Increased TH hormone (causes Graves disease, goiter)

Hypothyroidism Decrease production of TH + women have DG first! Hashimotos (chronic autoimmune thyroiditis Myxedema= intolerance to cold Myx coma tx w/synthroid Autoimmune disorder, iodine def, antithyroid drugs Slow metabolism, fatigue, constipation, slow hr, poor memory Decrease wbc Weight gain

Drugs Action/Side Effects

Graves-thyroidtoxicosis BIG EYES

Alterations in Clinical Signs & Symptoms :

Metabolic rate: tissue sensitivity to SNS

FAST BMR Heat production Low glucose

Weight/Fat TPR, BP Cardiac effects: SNS Cholesterol Fat metabolism Goiter Response to heat/cold Emotional changes Appetite, Weight changes Skin, hair, nails Reproductive effects Exophthalmos

metobolized yes yes

Lab findings:
T3, T4 Calcitonin

Low T4

PTH

Treatment/Nursing Care PTU(lueko/agranulo- LIVER test), tapazole, I 131,(sodium collects in thyroid and kills it) SSKI B adrenergic blocker_ Propanalol- tx heat intolerance, palpitations, nervousness Lugols sol before sx to prevent thyroid storm Na iodide for thyroid storm Synthroid Take on empty tummy Am same time ea day Adverse: hyper Increase tsh = decreased t3/4 need more drug!