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    This document summarizes a study on the role of genome duplication in the functional diversification of vertebrate microRNA genes. The objectives were to identify evolution of miRNA genes and changes in expression patterns, create databases of miRNAs for humans, mouse and rhesus, and develop a visualization tool for miRNA-target gene interaction. The work included designing an experimental results database, developing a network visualization module, and using Java, JSP, MySQL, and HTML. The conclusion is that human miRNA sequence variations alter predicted secondary structures but unlikely affect miRNA processing, and the database relates miRNAs to target genes with visualization.

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    This document summarizes a study on the role of genome duplication in the functional diversification of vertebrate microRNA genes. The objectives were to identify evolution of miRNA genes and changes in expression patterns, create databases of miRNAs for humans, mouse and rhesus, and develop a visualization tool for miRNA-target gene interaction. The work included designing an experimental results database, developing a network visualization module, and using Java, JSP, MySQL, and HTML. The conclusion is that human miRNA sequence variations alter predicted secondary structures but unlikely affect miRNA processing, and the database relates miRNAs to target genes with visualization.

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    7 views30 pages

    4 Srcmirna

    Uploaded by

    vishnuch57
    This document summarizes a study on the role of genome duplication in the functional diversification of vertebrate microRNA genes. The objectives were to identify evolution of miRNA genes and changes in expression patterns, create databases of miRNAs for humans, mouse and rhesus, and develop a visualization tool for miRNA-target gene interaction. The work included designing an experimental results database, developing a network visualization module, and using Java, JSP, MySQL, and HTML. The conclusion is that human miRNA sequence variations alter predicted secondary structures but unlikely affect miRNA processing, and the database relates miRNAs to target genes with visualization.

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    of 30

    ROLE OF GENOME DUPLICATION ON THE FUNCTIONAL DIVERSIFICATION OF VERTEBRATE miRNA GENES

    Internal Supervisor Uma rani Asst. Professor

    external Supervisor Dr . K . Ulaganathan Professor CPMB,OU

    By Ch vishnu 09031d7915 SIT,JNTUH

    Introduction
    y Segmental duplications (SDs) are low copy

    repeats (LCRs)

    y SDs play a role in creating new primate genes as

    reflected in human genetic variation.

    Objectives
     Identifying the evolution of miRNA genes and changes

    in expression patterns.
     Creation of Database for microRNA for Humans,

    mouse and Rhesus.


     Development of Visualization interaction for miRNA

    and target gene interaction.

    Databases
    y miRBase y microRNA y HMDD y mirTarBase

    Work and technology:


    Designing a database for the experimental results Developing GUI- network interaction visualizaton module
     Programming: Java, JSP  Database: MySQL  Front end: HTML

    CONCLUSION

    Extent and type of sequence variations of miRNAs present in human are altering the predicted secondary miRNA structure but they are unlikely to affect miRNA processing. This database gives the relation between the miRNA and the target gene along with the visualization.

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