SOLID DISPERSION RECENT ADVANCES Abstract: Solid dispersions have attracted considerable interest as an efficient means of improving the

dissolution rate and hence the bioavailability of a range of hydrophobic drugs. Most of the newly invented chemical entities are poorly water soluble. The preparation of solid dispersions, such as selection of carrier and methods of physicochemical characterization, along with an insight into the molecular arrangement of drugs in solid dispersions are also discussed. Definition of solid dispersions: The term solid dispersion refers to a group of solid products consisting of at least two different components, generally a hydrophilic matrix and a hydrophobic drug. The matrix can be either crystalline or amorphous. Solid dispersion studies earlier done by the polyvinyl pyrrolidine, mannitol, urea, poleethylene glycol, sodium starch glycolate, microcrystalline cellulose. Recently solid dispersion studies carried by different hydrophilic carriers such as Chitosan (minimum of 80% deacetylated) Eudragit E100 and Mannitol, Eudragit E100,Gelucir,Cyclodextrins, Modified locust beean gum,Locust bean gum, Poloxamers. Corboxy methyl cellulose sodium,Hydroxyl ethyle cellulose, Hydroxylpropylmethyl cellulose. Already few research have done by hydrophilic carriersSolid dispersions of piroxicam Solid dispersion with felodipine Solid dispersion of benznidazole Solid dispersion by Repaglinide. Solid dispersion by Aceclofenac