SYNTHESIS OF NANOSIZED HYDROXYAPATITE BY ELECTROCHEMICAL METHOD AS BONE AND TEETH BIOIMPLANT

Name

: Desi Liah Martasari (2308 100 017) Desy Nurwijayanti (2308 100 113) Department : Chemical Engineering FTI-ITS Advisor : Prof. Dr. Ir. Heru Setyawan, M. Eng

Abstract Nanosized hydroxyapatite has been an interest in biomaterials research lately. The main factor driving the use of hydroxyapetite as bone substitute materials is its chemical similarity to the mineral component of mammalian bones and teeth. It is non-toxic, biocompatible, not recognized as foreign materials in the body, and most importantly, both exhibit bioactive behaviour and integrate into living tissue by the same process active in remodelling healthy bone. Therefore, application and prospective use of the nanosized hydroxyapatite for a clinical repair of damaged bones and teeth is very promising. Nanosized hydroxyapatite forms have better densification and bioactivity compared with the larger ones. Thus, the nanosized forms of hydroxyapetite have a great potential to be used for those hard tissue-engineering application. The purpose of this research is to synthesize nanosized hydroxyapatite by an electrochemical method using constant direct current and to determine the best condition (current density, duration of electrolysis, the distance between two electrodes, electrolysis temperature, pH, and electrolyte concentration) to produce desirable characteristics of hydroxyapatite. This synthesis will be started by diluting Na2H2EDTA.2H2O, KH2PO4 and CaCl2 at concentration Ca/EDTA/PO43- 0,25/0,25/0,15 M. Then, it will be electrolized by using direct curent based on variabel choosed before. This process will produce deposit. After that, this deposit will be in aging process which will be filtered and washed then with demineralized water to eliminate impurities. Next, it will be dried in the certain temperature. The dried particles will be characterized by XRD, BET, FTIR, and by TG-DTA test. Key word: electrochemical method, nanosize, hydroxyapatite, synthesis, characterization