Dr. Ma. Lyn B.

Gabayeron MScD - Orthodontics

Provide instructions in making similar proteins that participate in chemical signaling pathways in the body; some of these proteins are specific to certain cells and tissues. There are 19 identified genes in the wnt gene family Wnt proteins are ligands which binds with receptors called Frizzled proteins on the surface of cells

WNT1 WNT2, WNT2B WNT3, WNT3A WNT4 WNT5A, WNT5B WNT6 WNT7A, WNT7B WNT8A, WNT8B WNT9A, WNT9B WNT10A WNT10B, WNT11 WNT16

It is the association of WNT proteins with Frizzled receptors, and the subsequent effects on beta-catenin This pathway promotes proliferation and differentiation

wnt5a is expressed in multiple outgrowing tissues Wnt5a is required for morphogenesis of all outgrowing structures Wnt5a is required for extension of the primary embryonic A-P axis Wnt5a is essential for outgrowth of the limb PD axis Wnt5a is required for the proliferation of progress zone and paraxial mesoderm progenitors

Wnt5a is essential for outgrowth of the genital tubercle They concluded that proximal-distal outgrowth of diverse structures in the vertebrate embryo is controlled by a common mechanism which requires wnt5a signalling therefore wnt5a is required during gastrulation for morphogenesis and axis extension