Mark (T) or (F)

1. In rigid redocking, ligand is protein while in rigid docking; both receptor and

ligand are proteins. 2. In LBDD protein ligand docking is the most suitable method of CADD techniques. 3. All 2 D protein structures downloaded from PBD lack hydrogen atoms and are solvated. 4. The main components of any docking software are search algorithm and score function. 5. When RMSD equals zero, it means that identical structures are being docked and this is unlikely to occur in protein protein docking. 6. Docking is the best method for identification of active site where the ligand binds. 7. Enzyme inhibitors often block its activity via reversible covalent interactions. 8. The best reliable method for evaluation of drugability of ligand is in silico screening. 9. The methods designed for search algorithm in autodock are simulated annealing and genetic engineering while in MOE dock are spheres and pharmacophore triad. 10. In flexible docking, either bond length or bond angles of the ligand is changeable. 11. The approximate total number of conformers in ligand containing 4 saturated bonds and three unsaturated bonds and = 30 0 is 4 X 107 conformers. 12. Two free available sites for downloading of 3 D protein structures are PBD and Pubmed.