Name Of Drug CEFUROIXIME SODIUM Action: Inhibits cell wall synthesis promoting osmotic instability; usually bactericidal.

>Antibiotic

Indication >Serious lower respiratory tract infection, UTI, skin or skin-structure infections, bone or joint infection, septicaemia, meningitis & gonorrhoea >uncompleted UTI

Adverse Effects >phlebitis, thrombophlebitis. >G.I.: diarrhea, pseudomembranous colitis, nausea, anorexia, vomiting >hematologic: haemolytic anemia, thrombocytopenia, transcient neutropenia, eosinophilia >skin maculopapular & erythematous rashes, urticaria, pain, induration, sterile sloughing at I.M. injection site. >other: anaphylaxis, hypersensitivity reactions, serum sickness

Contraindications >contraindicated in patients hypersensitive to drug or other cephalosporins. >use cautiously in patients hypersensitive to penicillin because of the possibility of crosssensitivity with other beta-lactam antibiotics. >use cautiously in breast-feeding women & in patients with history of colitis or renal insufficiency.

Nursing Considerations >monitor patients for signs and symptoms of superinfection. >look alike-sound alike: Dont confuse drug with other cephalosporins that sound alike.

CELOCOXIB Action: thought to inhibit prostaglandin synthesis, impeding COX-Z, to produce antiinflammatory, analgesic, & antipyretic effects.

>to relieve signs and symptoms of osteoarthritis & rheumatoid arthritis

>CNS: headache, dizziness, insomnia

>contraindicated in patients hypersensitive to drug, sulfomides, aspirins, or other

>drug can cause fluid retention; monitor patient with hypertension, edema or heart failure.