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  • Pathopysiology of Sle

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    Iresh Greta Matocenio
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    Systemic lupus erythematosus is caused by disordered T-cell function and hyperactive B cells that produce a variety of autoantibodies against normal body components. These autoantibodies form immune complexes that deposit in tissues, triggering inflammation and local damage. SLE can affect many organs including the kidneys, central nervous system, brain, heart, lungs, skin, and gastrointestinal system, causing symptoms like arthritis, rashes, and organ dysfunction.

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    Systemic lupus erythematosus is caused by disordered T-cell function and hyperactive B cells that produce a variety of autoantibodies against normal body components. These autoantibodies form immune complexes that deposit in tissues, triggering inflammation and local damage. SLE can affect many organs including the kidneys, central nervous system, brain, heart, lungs, skin, and gastrointestinal system, causing symptoms like arthritis, rashes, and organ dysfunction.

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    28 views1 page

    Pathopysiology of Sle

    Uploaded by

    Iresh Greta Matocenio
    Systemic lupus erythematosus is caused by disordered T-cell function and hyperactive B cells that produce a variety of autoantibodies against normal body components. These autoantibodies form immune complexes that deposit in tissues, triggering inflammation and local damage. SLE can affect many organs including the kidneys, central nervous system, brain, heart, lungs, skin, and gastrointestinal system, causing symptoms like arthritis, rashes, and organ dysfunction.

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    PATHOPYISIOLOGY OF SYSTEMIC LUPUS ERYTHEMATOSUS

    Disordered T-cell function (cellular immune response) Hyperactivity of B cells (humora response) Production of a large variety of autiantibodies against normal body components (nucleic acid, erythrocytes, coagulation protein, lymphocytes & platelets) SLE auto-antibodies react with corresponding antigen forming immune complex

    SLE auto-antibodies deposited in the connective tissues of blood vessels, lymphatic and other tissues The deposits trigger inflammatory response leading to local tissue damage

    Affects kidneys, MS system, brain, heart, spleen, lungs, GI, skin and peritoneum

    Manifestations: mimics RA: fever, anorexia, malaise, weight loss, multiple arthralgias and symmetric polyarthritis; butterfly rash, photosensitivity, discoid lesion, hives, alopecia, mucous membrane ulceration, enlarged glands, edema in the legs and around the eyes, pale cyanotic fingers and toes Other Effects: Kidneys: proteinuria, cellular casts Nephrotic Syndrome & Renal Failure Hematologic: Leukopenia, Anemia and thrombocytopenia Cardiovascular: Pericarditis, vascilitis & Raynauds phenomenon Pulmonary: Pleurisy, Pleural Effusion & Lupus Pneumonitis

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