Descriptive Analysis of Pilocytic Astrocytomas using SEER 13 registry (1992-2002) and SEER 9 registry (1973-2002) data Bridget J.

McCarthy, Ph. D. Central Brain Tumor Registry of the United States

Brain Stem Pilocytic Astrocytoma Statistics Selection: Histology = 9421 (Pilocytic astrocytoma) Primary site = C71.7 (Brain Stem: includes cerebral peduncle, basis pedunculi, choroid plexus of fourth ventricle, fourth ventricle NOS, infratentorial brain NOS, medulla oblongata, midbrain, olive, pons, pyramid)

Table 2. Annual percent change and incidence rates/100,000 person-years from the SEER 13 registry (1992-2002) data set by gender and race, age-adjusted to the 2000 US standard population. 1992-2002 (13 registries) N Rate/Trend (95% CI) Overall Incidence 124 0.029 (.024-.035) 1992-2002 Annual Percent Change (APC) Gender: Male Female Age at Diagnosis: 0-14 years < 20 years 20+ years Race: Caucasian African American Asian/Pacific Islander -0.1 (-5.9-6.0) [No trend in incidence]

60 64

0.028 (.021-.037) 0.030 (.023-.039)

77 86 38

0.083 (.066-.104) 0.070 (.056-.087) 0.013 (.009-.017)

100 9 10

0.031 (.026-.038) 0.016 (.007-.036) 0.022 (.010-.045)

Incidence/100,000 person-years

0.12 0.10 0.08 0.06 0.04 0.02 0.00 0 01-04 years 05-09 years 10-14 years 15-19 years 20-24 years

Figure 6. Incidence rates for brain stem pilocytic astrocytoma by age at diagnosis; SEER 19922002, 13 registries.
Malignant tumor 5% 2% Malignant glioma Ependymal tumors Astrocytoma, NOS 34% Anaplastic astrocytoma Fibrillary astrocytoma 11% 2% 4% 12% 13% Pilocytic astrocytoma Glioblastoma Medulloblastoma PNET Lymphoma 24 other histologies

4% 4% 4% 6%

Figure 7. The percentage of tumors in the Brain Stem (site code C71.7) by specific histology; SEER 1992-2002, 13 registries.

100 90 80 70 60 50 40 30 20 10 0 0 12 24 36 48 60 Months since diagnosis

% Survival

All Pilocytic All Brain Stem Pilocytic

Figure 8. Comparison of the relative survival rates for all pilocytic astrocytoma and brain stem specific pilocytic astrocytoma; SEER 1973-2002, 9 registries. - No significant differences between the two groups.
Brain Stem Pilocytic Astrocytomas
100 90 80 70 60 50 40 30 20 10 0 0 12 24 36 48 60 Months since diagnosis

% Survival

Male Female

Figure 9. Relative survival rates for brain stem pilocytic astrocytoma by gender; SEER 19732002, 9 registries. - No significant differences between the two groups.

100 90 80 70 60 50 40 30 20 10 0 0 12 24 36 48 60 Months since diagnosis

Brain Stem Pilocytic <20 yrs Brain Stem Pilocytic 20+ yrs Pilocytic at other sites <20 yrs Pilocytic at other sites 20+ yrs

Figure 10. Relative survival rates for brain stem pilocytic astrocytoma and for pilocytic astrocytoma for all other Brain and CNS sites by age groups (<20 years and 20+ years); SEER 1973-2002, 9 registries. - Significantly lower survival was found in those 20+ years at diagnosis compared to those <20 years at diagnosis.

% Survival

References: Surveillance, Epidemiology, and End Results (SEER) Program (www.seer.cancer.gov) SEER*Stat Database: Incidence - SEER 9 Regs Public-Use, Nov 2004 Sub (1973-2002), National Cancer Institute, DCCPS, Surveillance Research Program, Cancer Statistics Branch, released April 2005, based on the November 2004 submission. Surveillance, Epidemiology, and End Results (SEER) Program (www.seer.cancer.gov) SEER*Stat Database: Incidence - SEER 13 Regs Public-Use, Nov 2004 Sub for Expanded Races (1992-2002), National Cancer Institute, DCCPS, Surveillance Research Program, Cancer Statistics Branch, released April 2005, based on the November 2004 submission.

Analyses conducted and provided by the Central Brain Tumor Registry of the United States using SEER 13 registry (1992-2002) and SEER 9 registry (1973-2002) data. The CBTRUS is not responsible for interpretations of these data made elsewhere and restricts its support to its analyses and statements placed on this website.