Evaluation: Pharmacology UY1/FMSB/L3S5/PHCL/Drugs Affecting Hemopoeitic & Locomotor Syetems Jan2011 : ---- 60mins ; Score: ..

/40pts Section A: Multiple Choice Questions (Choose the ONE best answer)

[e] Dexamethasone

8. The anti-gout drug Febuxostat (ADENURIC)

[a] Is an analogue of xanthine [b] Is a purine analogue [c] Has anti-inflammatory effects [d] Is a selective inhibitor of xanthine oxidase [e] None of the above

1. Which of the following agents could be given in combination with Non

2.

3.

4.

5.

6.

7.

Steroidal Anti-Inflammatory agents for the protection of gastric mucosa from adverse effects? [a] Celecoxib [b] Paracetamol [c] Misoprostol [d] Dexamethasone [e] Low dose aspirine High levels of serum uric acid could be treated using which of the following? [a] Colchicine [b] Allopurinol [c] Indomethacin [d] All of the Above [e] None of the above Which of the following is best for rapid symptomatic relieve of an acute crisis of gouty arthritis? [a] Allopurinol [b] Indomethacin [c] Probenecid [d] Methotrexate [e] Cyclophosphamide At what dose does Aspirine exhibit adequate and safe therapeutic antiinflammatory effects? [a] 125mg per day [b] 325mg per day [c] 1g per day [d] 4g per day [e] 20g per day Which of the following NSAID could be used to treat Patent Ductus Arteriosus in children? [a] Aspirine [b] Paracetamol [c] phenylbutazone [d] Sulindac [e] Indomethacin Which of the following corticosteroids has the most potent antiinflammatory agent? [a] Prednisolone [b] Triamcinolone [c] Betamethasone [d] Fludrocortisone [e] Dexamethasone Which of the following corticosteroids has the longest half-life? [a] Prednisolone [b] Triamcinolone [c] Betamethasone [d] Fludrocortisone

9. What is the main advantage of using Disease-Modifying Anti-Rheumatic Drugs

(DMARDS) rather than NSAIDs as regards drug management of severe rheumatoid arthritis? [a] DMARDs provide a more rapid relieve of symptoms [b] DMARDs are better tolerated than NSAIDs [c] DMARDs retards disease progression better than NSAIDs [d] DMARDs are cheaper [e] Not all NSAIDs selectively inhibit COX-2 10. Aplastic anaemia could result from the use of which of the following drugs? [a] Phenytoin [b] Isoniazid [c] Chloramphenicol [d] Heparin [e] Dapsone 11. Megaloblastic anaemia could result from the use of which of the following drugs? [a] Phenytoin [b] Isoniazid [c] Chloramphenicol [d] Heparin [e] Dapsone 12. Lepirudin (REFLUDAN) and Bivalirudin (ANGIOMAX) are recombinant derivatives of the hirudine that is secreted in the saliva of leeches (FR: sangsue) [a] They act as thrombolytics [b] They are indirect inhibitors of thrombine [c] They have an anti-platelet effects [d] They have anti-fibrinolytic effects [e] They are direct inhibitors of thrombine 13. Recombinant t-Plasminogen Activator(Alteplase) is preferable to streptokinase for clinical use as a fibrinolytic agents because [a] Streptokinase is less antigenic [b] Streptokinase has a very long half life [c] Alteplase has an additional anti-platelet effects [d] Streptokinase could cause circulatory shock [e] Alteplase is neutralised by anti-streptokinase antibodies due to previous infections streptococci 14. The mechanism of action of the anti-influenza virus agent Oseltamivir involves the inhibition of : [a] RNA Polymerase [b] Thymidine kinase [c] Reverse transcriptase [d] Topoisomerase [e] Neurminidase Page 1 sur 3

15. Neurotoxicty of anti-mitotic agent vincristine could be explained by

[a] Inhibition of the proliferation of nerve cells [b] Reduces the plasma concentration of cobalamine [c] Inhibits the functioning of microtubules [d] Demyelisation of nerve cells [e] Inhibits DNA synthesis 16. Which of the following drugs could have hyper--coagulation effects?
[a] Ceftriaxone [b] Low dose aspirin [c] Oestrogen [d] Heparin [e] Erythromycin

17. What is the main reason for the contra-indication of thrombolytic therapy in
Pregnancy?
[a] Teratogenicity [b] Mutagenicity [c] Anaemia [d] Retro-placental haematoma [e] Gastro-intestinal haemorrhage

[c] Artemether [d] Mefloquine [e] None of the Above 23. Which of the following families of anti-malarials has the shortest half-live? [a] 4-aminoquinoline (eg amodiquine) [b] Aryl-methanol (eg quinine) [c] Anti-folates (eg pyrimethamine) [d] Artemisinine derivatives (eg Artesunate) [e] 8-aminoquinolines (eg Primaquine) 24. Intermittent preventive therapy of malaria has been recommended to pregnant women living in Africa. Which of the followinganti-malarial drugs or drug-combination is of first choice in Cameroon? [a] Quinine [b] Mefloquine [c] Sulphadoxine/pyrimethamine [d] Atovaquone/proguanil [e] Chloroquine/proguanil

18. Which of the following family of anti-retroviral agents has as adverse

effects, lipodystrophy and hyperlipidemia?
[a] Protease inhibitors [b] Non-nucleotide Reverse Transcriptase inhibitors [c] Nucleotide Reverse Transcriptase Inhibitors [d] Nucleoside Reverse Transcriptase Inhibitors [e] Fusion Inhibitors

19. Which of the following anti-retroviral agent is most frequently associated

with increases in the level of hepatic transaminases? [a] Zidovudine (AZT) [b] Nevirapine (NVP) [c] Nelfinavir (NFV) [d] Lamivudine (3TC) [e] Tenofovir (TFV) 20. Which of the following anti-retroviral agents should not be used during pregnancy for the prevention of mother to child transmission of HIV virus? [a] Zidovudine (AZT) [b] Nevirapine (NVP) [c] Efavirenz (EFV) [d] Lamivudine (3TC) [e] None of the above 21. The high vulnerability to drug-drug interactions of protease inhibitors (PI) is due to : [a] Interactions at the level of absorption in the gastrointestinal tract [b] Interactions at the level of site of action [c] Interactions at the level of renal excretion [d] PI are metabolized by the Cytochrome P450 system [e] PI are transformed by glucuronidation and sulfatation 22. Some anti-malarial drugs interact with drugs that cause prolongation of Q-T interval on ECG thereby predisposing to arrhythmias. Which of the following is EXEMPTED? [a] Oral quinine [b] I.V. quinine

The following are drugs are anti-neoplastic agents [a] Cyclophosphamide [b] Methotrexate [c] Palitaxel (Taxol) [d]Tamoxifen [e] Bleomycin [f] Hydroxyurea For questions 11-13 choose a drug from above that is best indicated for the cited clincal form of neoplasm:

25. Acute lymphocytic leukemia: ___ 26. Anti-eostrogen for Breast Cancer treatment:: _ _ _ 27. Chronic granulocystic leukemia: ___

Drugs that modulate blood clotting and coagulation, a. b. c. d. e. f. Aspirine Dipyridamole Ticlodipine Aminocaproic acid Tranexamic acid epoprostenol

For questions 28-30, choose ONE drug from the above list that corresponds to the mechanism of action as described below: Page 2 sur 3

28. Hemostatic agent which is an inhibitor of plasminogen activity: ___ 29. Anti-platelet agent which is a prostacyclin derivative: ____ 30. Antiplatelet agent which is an inhibitor of the synthesis of the platelet activator thromboxane
2 : ___

______________________________________________________________ ______________ Section B: (10pts). Open Questions

31. Give concise classification of the antimalarial drugs with reference to the stage of action in the
parasite life cycle. (3pts)

32. Referring to anti-neoplastic agents, give a tabulated comparison (a drug example,

pharmacologic effect, specificity of action, optimal dose determination, toxicity) between cytotoxic agents and targeted cancer therapy agents. (3pts)

33. What are drug-drug interactions involving warfarin that could increase or decrease the anticoagulant effects of this oral anti-coagulant? (4pts)

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