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  • Pathophysiology of Heart Failure: Activation of Rennin-Angiotensin-Aldosterone System

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    Jho Ocampo Nungay
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    Heart failure occurs due to myocardial dysfunction which decreases cardiac output and blood pressure, activating the renin-angiotensin-aldosterone system and sympathetic nervous system. This leads to vasoconstriction, increased afterload and blood pressure, heart rate increases, and ventricular remodeling over time. Complications of heart failure include myocardial infarction, acute renal failure, stroke, and diabetic ketoacidosis.

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    Heart failure occurs due to myocardial dysfunction which decreases cardiac output and blood pressure, activating the renin-angiotensin-aldosterone system and sympathetic nervous system. This leads to vasoconstriction, increased afterload and blood pressure, heart rate increases, and ventricular remodeling over time. Complications of heart failure include myocardial infarction, acute renal failure, stroke, and diabetic ketoacidosis.

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    86 views10 pages

    Pathophysiology of Heart Failure: Activation of Rennin-Angiotensin-Aldosterone System

    Uploaded by

    Jho Ocampo Nungay
    Heart failure occurs due to myocardial dysfunction which decreases cardiac output and blood pressure, activating the renin-angiotensin-aldosterone system and sympathetic nervous system. This leads to vasoconstriction, increased afterload and blood pressure, heart rate increases, and ventricular remodeling over time. Complications of heart failure include myocardial infarction, acute renal failure, stroke, and diabetic ketoacidosis.

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    PATHOPHYSIOLOGY OF HEART FAILURE

    Myocardial Dysfunction(Ischemic heart disease)

    Dec. cardiac output Dec. systemic blood pressure Dec. perfusion to lidneys activation of baro receptors (left ventricle,aortic arch,carotid sinus)
    Activation of renninangiotensin-aldosterone system

    Angiotensinogen Angiotensin I(Lungs) Angiotensin II Inc aldosterone (sodium and water retention,arginine vasopressin,endothelin,cytokines)

    Stimulation of vasomotor regulatory centers in medulla

    Activation of sympathetic nervous system

    Inc. catecholamines(epinephrine and norephinephrine)->vasoconstriction

    Vasoconstriction (inc afterload, increase BP, increase heart rate)

    VENTRICULAR REWMODELLING

    Pathophysiology of Myocardial Infarction ( M.I.)

    ACUTE RENAL FAILURE

    STROKE

    DKA

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