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Medicine Feb. 2011 FCPS Part1 Q BANK

1. Lamellar bodies are found in ; - clara cells ( ans) - type1 alveolar - type2 alveolar - macrophages 2. Maximum water and electrolyte absorption occurs in : - ileum - stomach - large intestine (ans) 3. Most slow growing thyroid cancer: - papillary carcinoma (ans) - anaplastic - mataplastic - follicular 4. Cerebral malaria most commonly associated with : - p.falciparum(ans) - p.malaria 5. Mandibular joint is an example of: - gomphosis - symphysis (ans) - syndesmosis - synchondrosis 6. Adrenergic discharge causes : - pupillary dilation (ans) - vasodilation in skeletal muscle - increased activity of gut - decreased heart rate 7. Best method to detect malignancy : - cytological - histopathological - immunochemical 8. HIV diagnosis through : - elisa - western blot (ans) - CD count < 300 9. Following is true for stomach: - fundus lies above cardiac orifice (ans) - antrum lies b/w insisura and pylorus 10. Anterior inferior cerebellar artery is a branch of : - vertebral a - basilar a (ans)

11. Following is true regarding cavernous sinus : - donot communicate with each other - abducent n runs along lateral border - contain numerous trabeculae(ans) - drain directly into sigmoid 12. Stratified squamous epithelium found in: - renal tubular cells - secretory ducts of salivary gland (ans) 13. Head injury causes paraplegia , no sensory loss, which area involved? - cerebral cortex - spinal cord at T10 level - pons - medulla oblongata 14. Vitamin D causes: - increased renal ca reabsorption - increased serum phosphate levels(ans) 15. Following is quick antidote of warfarin : - FFP (ans) - Vitamin k 16. Antithrombin is a protease inhibitor that : - have structure similar to thrombin - is a valine protease inhibitor - when binds to protease its action is increased by heparin(ans) 17. ADH: - has double size as compared to oxytocin - released on deceased osmolarity - is transported down attached to neurophysin 18. Glucocorticoids : - decrease FA uptake by liver - decreasd lipolysis - deceased proteolysis - decrease utilization by cells(ans) 19. HIV infection in female will cause: - vulvar cancer - endometrial CA - cervical CA - leukemia 20. A pregnant lady has bile duct obstruction , which marker is best : - alkaline phosphatase - Gama glumatyl transferase (ans) 21. A student when asked a question turns red , which mechanism involved: - active hyperemia(Ans) - passive hyperemia 22. A patient with increased conjugated , unconjugated bilirubin and urobilinogen , with splenomegaly , : - viral hepatitis - hemolytic anemia(ans)

- cholestasis 23. ALT raised in: - viral hepatitis(ans) - alcoholic hepatitis 24. A women with increased ALT , AST , GGT , ALP - viral hepatitis - cholistasis(ANS) 25. Following is not a sign of irreversible injury: - karrorhexis - karyolysis - mitochondrial shrinkage - myelin figures (ans) reference :General.patho brs 26. Ectopic thyroid hormone production by : - pancreatic cancer - adenocarcinoma of stomach - small cell ca of lung - squamous cell ca of lung - bronchial carcinoid (ans) 27. Polyarteritis nodusa (PAN) following is diagnostic: - fibrinoid necrosis of arterioles (Ans) - edema 28. Type of necrosis in omentum: - liquifactive - gangrenous - coagulative 29. Which antibody croses placenta: - IgG(Ans) - IgM - IgA 30. Azathioprine: - toxicity increase with xanthine oxidase - inhibit synthesis of folic acid (ans) 31. A kidney transplant immediately turns blue and is rejected with in minutes: - type 4 hypersensitivity reaction - Ab. Mediated rejection (ans) - Cytotoxic rejection - GVHD 32. Dry eyes, dry mouth . . which AB should be tested: - SSa (Ans) - ANA - Ds DNA - Jo 33. Sulphonamides: - inhibit cell wall synthesis - inhibit folic acid synthesis(ans) 34. Which anti TB drug is bacteriostatic? - INH (ans) - Rifampicin

- Streptomycin - Pyrazinamide 35. Klebsiella: - is motile - gram positive rod - cause 3% of community acquired pneumonias (ans) 36. A thyrotoxic pt with atrial fibrillation which drug should be given: - Amiodarone - B blocker(Ans) - Digoxin 37. Insulin secretion inhibited by: - glucagon - B blocker (Ans) 38. A pt with acute LVF presents in ER , treatment should commence with: - I/v frusemide (ans) - I/v digoxin 39. Pin worm infection caused by: - larval ingestion - egg ingestion (ans) - directly through skin 40. Echoviruses usually cause : - meningo-encephalitis (ans) 41. Greater petrosal n enters which ganglion: - pterygopalatine(Ans) - otic - submandibular 42. A warty growth on vulva due to viral infection : - condylomata acuminatum (ans) - sq. papilloma 43. Trachoma caused by: - chlamydia sp(ans) - pseudomonas 44. Candida albicans following is unlikely: - normal GI flora - forms germ tubes - common cause of UTIs (ans) 45. Following is a premalignant lesion: - intradermal nevus (Ans) ? - junctional nevus - condyloma 46. An organism first produses lung abscess and later meningitis which is likely: - S. aureus - Pneumococci (Ans) - Streptococci 47. Post op wound causes greenish pus discharge which org;

- Pseudomonas (ans) - klebsiella 48. A pt requires repeated blood transfusions, has non-healing leg ulcers, with abdominal and chest pain. Peripheral film shows: - Sickle cells (ans) ( this mcq is present in brs patho exersise) 49. A diabetic with hyper osmolar coma what should be given ; - INH insulin - Regular (ans) - Lente 50. Which of the following causes viral mediated host DNA transfer: - Transduction (Ans) - Transformation - Conjugation 51. Which of the following most probably has animal reservoir: - Influenza (ans) - Small pox - Measeles 52. A pt has atypical lymphocytes, enlarged LNs, which test should be performed : - Monospot test ( in brs patho exercise) 53. Following most obvious sign of malignancy; - loss of differentiation - increased nuclear- cytoplasmic ratio - metastasis (ans) ( reference brs patho and azeem sheikh) 54. Aspirin not given in ; - Peptic ulcer (ans) - MI - Angina 55. Vitamin k following is unusual: - Coumarin therapy - Bile duct obstruction - Red meat ingestion (ans) - In newborn due to lack of transport through placenta 56. Primitive streak mesoderm migrates to anterior abdominal wall and around cloaca , a rupture of this mesoderm cranially will produce : - Ectopic anal opening (ans) - Imperforate anus - Recto-vesicle fistula 57. A research study done in elderly population 3 patients had a common cause what it could be: - Phimosis - Hsv infection

58. Which of the following is true regarding kidneys : - lie opposite L1-3 - right higher than left - lower poles lie more medially than upper (ans) ? 59. Following is true regarding accessory n:

- Cranial root joins vagus outside skull (Ans) ? - Nucleus lies in medulla 60. Syringomyelia: - Ependymal lining - Cerebellar ectopia - Enlarged ventricle (ans) 61. Ventral spinothalamic tract carries : - pain - temp no touch option was given 62. Temperature regulation through: - Anterior hypothalamus ( Ans) - Posterior hypothalamus 63 . Libmann sac endocarditis. . . . . following valve/valves affected: - Aorta - Aorta and mitral (Ans) - Tricuspid and mitral - Pulmonary and aorta 64. Posterior 1/3 of interventricular septum undergoes infarct which a affected: - Right coronary a(ans) - Left coronary a - Marginal a - Circumflex a 65. Following is a chemical carcinogen - asbestos (Ans) - coal - alcohol 66. Following is false regarding adrenals: - have direct supply from aorta (ans) - 3 sourses of blood supply - from phrenic a - bld from renal a 67. The hilum of kidney doesnot contain: - pelvis - parasympathetics - renal a - renal vein - part of adrenal gland (ans) 68. Which structure arches over the left lung : - arch of aorta (ans) ? - azygous v 69. Notochord; - induces neural plate formation (ans) - develops into brain - develop into spinal cord 70. Chorionic villi: - anchor fetus to maternal placenta (ans)

- by 1st week surrounds whole fetus - are called primary villi when invasion by mesoderm - completely develop by 1st week 71. Diagnosis of turner syndrome by: - karyotyping 72. Following amino acid is not synthesized in body : - methionine (ans) ? - glutamate - alanine - no option for leucine and iso leucine 73. DNA replication occurs in: - anaphase - interphase (ans)\ - metaphase - telophase 74. Following a cause of flat facies , oblique fissures, and mental retardation : - downs (Ans) - Edward - Patau 75. Which genetic disease most common : - X linked ressesive - Autosomal dominant - Multifactorial (ans) - Autosomal ressesive 76. Hemolytic anemia in hereditary spherocytosis is most probably dueto : - osmotic fragility (ans) ( in brs patho exercise) 77. A pale child , hair on end pattern on skull x-ray , what is the best way to diagnose: - hemoglobin electrophoresis (ans) - peripheral smear 78. There was a long family history of hemolytic disease in both male and female children , both APTT and bleeding time are prolonged . what is the diagnosis : - Vonwillebrand disease (ans) - Classic hemophilia 79. A pt is suffering from malignant disease , who should be informed ? - the family not the patient - the pt not the family - hide some information from the patient - provide crisp, clear information to the patient (ans) 80. A group with a disease and a group without tested for a risk factor : - cohort - case control (ans)

81. A pt died of metastatic cancer , his father also died of metastatic cancer , his colon shows polyps they are : - metastatic - adenomatous (ans) - papilloma

82. Following has lymphoid tissue with surrounding stratified squamous epithelium : - lymph node - palatine tonsils (ans) - spleen ( mcq present in azeem sheikh) 83. Following not directly related to reaction against antigen : - Spleen - Peyers patches - Thymus (ans) - Lymph nodes 84. Following has most mucous accini : - Brunners glands - Sublingual glands (ans) - Submandibular - Parotid 85. Saliva: - Is hypo tonic (ans) - Has low HCO3 - Contain high sodium - Contain low K 86. Trypsinogen is activated by : - enterokinase (ans) - peptidase 87. Hemolytic anemia results in increased blood hemoglobin levels , hb will appear in urine when which of following protein become saturated : - albumin - globulin - haptoglobin (ans) 88. Addition of glucoronic acid to drug : - makes drug more toxic - make it more water soluble (ans) - is a phase 1 reaction - require P450 - is same in children and adult 89. Oral glucose is better tolerated than I/V b/c : - Glucose insulinotropic peptide (ans) ( Ref ; physio brs)

90. A woman has weakness in both flexing thigh and leg , which muscle is damaged: - Adductor magnus - Sartorius (ans) - Biceps femoris - Semitendinosus 91. Dorsalis pedis artery : - lies b/w tendons of tibialis anterior and flexor hallucis longus - leaves through 1st and 2nd metatarsal space (ans) 92. Tumor in superior lobar bronchus; which bronchopulmonary segment affected: - apical superior (ans) - apical basal

- anterior basal - middle anterior 93. Bronchopulmonary segment ; - surrounded by C.T - is a functional, anatomical, and surgical unit (ans) - veins lie in center 94. Which causes local edema: - Allergy (ans) - Nephrotic syndrome - Portal htn - Hypoalbuminemia 95. Ovaries: - ovarian A arises from internal iliac A - drains into paraaortic LNs (ans)

96. Small intestines : - supplied by superior and inferior mesenteric artery - no part is retroperitonial - lymph drains into celiac and superior mesenteric LNs (ans) 97. Liquid dysphagia is dueto : - hypoglossal n palsy - plummer-vinson syndrome - palatal palsy - Neuromuscular incordination (ans) ? 98. IVC: - Commences in front of 5th lumbar vertebre (ans) - Is formed by union of splenic vein and portal vein 99. ACTH: - Released by releasing hormone from hypothalamus (Ans) - Causes increased aldosterone 100. Action of LH on testes does not result in increased cortisol production dueto : - Testes lack enzymes (ans) - Lack of binding protein 101. A woman complains of diplopia , temporal headache : - Gaint cell arteritis (ans) - Takayasu arteritis 102. A man died 5 days after MI, large blood clot found in pericardial sac . . he died dueto : - Pericardial tamponade (ans) - Viral infection 103. There is a growth along ligamentum arteriosum , which structure will be affected : - Left recurrent laryngeal n (ans) - Phrenic n - Vagus n 104. Increased interstitial fluid production, due to: - decreased plasma colloid pressure (ans) - decreased lymphatic flow - arterial constriction

105. Most important mechanism of blood flow in skeletal muscle during exercise : - local metabolites (ans) - sympathetic discharge 106. Increased renal sodium clearance dueto - increased renal blood flow - decreased renal sodium reabsorption (ans) - dehydration 107. Decreased angiotensin levels due to : - increased extracellular volume (ans) - increased renin - increased Na delivery to DCT 108. Following has 70% O2 extraction : - cardiac muscle - brain (ans) - liver - testes 109. Trachea shifted to left , resonant note on right side : - right pneumothorax (ans) - left pnemothorax - pleural effusion 110. Which of the following is rapidly adapting : - baroreceptors - pacinian corpuscle (ans) ? - free n endings - golgi tendon organ 111. Peripheral chemoreceptors : - have increased O2 consumption (ans) - detect increased CO2/ PH - respond on PO2 less than 50 112. Saw tooth waves: - atrial flutter (ans) - atrial fibrillation - ventricular tacchycardia 113. Regarding ECG following is true : - p waves occur before ventricular contraction (ans) - ventricles are depolarized during QT interval - 1st heart sound occurs during isovolumetric ventricular contraction 114. Resistance to blood flow increases with : - increased viscosity (ans) - increased vessel wall thickness - increased radius 115. Calculate Ejection Fraction if HR : 70, CO : 5.6 L, EDV : 160 ml. - 0.50 (ans) - 0.55 - o.60 116. External carotid artery in neck distinguished on basis of :

- having branches in neck (ans) - runs in carotid sheath - gives inferior thyroid artery ? 117. Erythropoietin produced by : - PCT - Mesengial cells - Renal tubular cells (ans) 118. Bioavailability checks drug availability when given : - I/V - Orally (ans) ? - Subcutaneous - IM 119. Claw hand produced by unopposed action of : - flexor digitorum longus and flexor digitorum profundus - extensor digitorum longus and ext. indices - ext.digitorum and flexor digitorum profundus (ans) 120. Inflamatory exudates contains : - proteins >3 mg (ans) - sp.gravity 1.01 - no cells 121. A women after an operation develops dispend due to : - pulmonary embolism (ans) - stress - pneumonia 122. Which of the following is most common cause of dispend leading to shock and death : - Fat embolism (ans) ? - Thrombo-embolism 123. Axilla is injected to nerve block , sensations on lateral side of forearm remain intact , which n. is spared : - radial - musculocutaneous (ans) - ulnar 124. Ca released in muscle from : - SR (ans) - Myosin - Sarcoplasm - Actin 125. Aspirin inhibits platelet aggregation by inhibiting : - thromboxane A2 (ans) 126. Histamine and heparin released by : - Basophils (ans) - Neutrophils - Lymphos 127. A baby with erythoblastosis fetalis needs exchange transfusion, baby is A+ , which blood should be transfused : - A+ - A- (ans)

- AB - O+ 128. In which stage is maximum hemoglobin production : - normoblast - pronormoblast - proerythrocyte (Ans) ? - reticulocyte 129. Hypomagnesaemia causes : - hyperreflexia 130. Digoxin toxicity is increased by : - hydrochlorothiazide ( exp : by producing hypokalemia , guess present in azeem sheikh) 131. Fibrous and parietal pericardium receive n supply from : - Phrenic N - Recurrent laryngeal n - Vagus n (ans) - Thoracic sympathetic n 132. Avulsion of phrenic n at its origin causes : - loss of sensation in central part of diaphram - loss of respiratory reflex (ans) - weakning of intercostals muscles 133. One of the following is not a normal body response to bomb blast: - Hypoglycemia (ans) 134. Which of following is true regarding Normal distribution curve : - Has central convex peak with concave tail (ans) - Positive skewing , peak is on right side 135. The most important criterion for cancer screening test is: - The cancer could be detected at an early stage (ans) - the disease is curable at an early stage 136. Monocyte : - contains granules in cytoplasm - arises from lymphoid tissue - inhibited by cytokines - leaves blood to enter tissues and then re-enters blood (ans) 137. Following is most important in delayed wound healing : - Anemia (ans) - Granulomata - Fat embolism - Malignancy - Fever 138. A pt with h/o TB now presents with lymph node swelling in neck . diagnosis of TB will be conformed by : - montoux - PPD - Langerhans cells - Caseation necrosis (ans) 139. Which of the following is passively reabsorbed through renal tubules :

- Na -K - PO4 - Urea (Ans) 140. Which of the following is an example of primary active transport : - H-K pump in stomach (ans) - Na-glucose co-transport in intestine - Na- Amino acid co-transport in intestines 141. Which of the following contain oxidases : - Lysosomes - Peroxisomes (ans) 142. Which of the following informs about tension developed in the muscle : - golgi tendon organ (ans) - muscle spindle 143. Following is true regarding cervical spinal nerves : - all part arises from neural crest cells - emerge through intervertebral foramen (Ans) - dorsal root ganglion is intraspinal - C7 nerve leaves through C7-T! foramen 144. A pt develops pain and vesicles on right eye lid and tip of nose , which nerve is involved : - Facial n - Maxillary n - Mandibular n - Right ophthalmic n (ans) 145. GFR is increased with a decrease in : - Afferent arteriolar resistance (ans) - Efferent arteriolar resistance 146. The best way to measure decreased GFR is through : - Decreased creatinine clearance (Ans) - Increased serum creatinine levels 147. A patient has pneumoconiosis which is predominant pathology in lung ? - Pulmonary fibrosis - Cavitary lung lesions - Tubercles - Lung collapse 148. CSF : - produced from choroids epithelium (ans) - PH changes occur rapidly following blood PH changes 149. Which of following is best measure of preload? - EDV (Ans) - CVP - ESV 150. A pt suffers from proximal myopathy , anti Jo Ab positive . what could be associated with it ? - Arthritis - Skin rash (Ans) - Cardiac involvement

151. Which of the following does not undergo metaplasia ; - Brain (ans) - Bronchial epithelium - Gallbladder duct 152. Staging is a method of determining : - Tumor invasion (Ans) - Degree of differenciation 153. Average life of gastrointestinal epithelium is : - 2-7 hours - 5 months - 2-7 days (ans) - 5 years 154. Which of following causes shift of O2-Hb dissociation curve to left ? - Decrease in temperature (Ans) - Increase in temp. - Increase 2-3DPG - Increase in H ions 155. Primary dehydration results in: - hypertonic ECF - isotonic ECF - hypotonic ECF 156. Pure water lost from the body what should be given ? - N.S (Ans) ? - Normal saline - 1/3 N.S - 5% dextrose 157. Which of the following can be measured by spirometer ? - VC (Ans) - RV - TLC 158. A couple have there first child with Downs , both are young , mother has robertsonian translocation . what is the risk of downs in their next baby : - 33% (ans) - 66% - 1% 159. Babinski sign is positive in : - Pyramidal track lesion (ans) - Spinothalamic tract lesion - Dorsal column lesion - Lower motor neuron lesion 160. Which of the following is the biggest reservoir of blood ; - arteries - arterioles - heart - capillaries - veins and venules (ans) 161. The label on a drug got removed accidently such that neither the doctor knows nor the patient it is : - double blinded (ans)

- single blinded 162. Diverticular disease is most common in : - Ceacum - Sigmoid colon (Ans) - Rectum 163. Which cell produces antibody : - Plasma cell - Lymphos - Monocytes 164. Pneumotaxic center : - increase respiratory rate - is main respiratory control center - when stimulated can decrease breaths upto 6 breaths/ min (ans) 165. If 1 liter blood is donated than which of the following take most long to return to normal ? - BP - Aldosterone/rennin levels - ECF volume - RBCs (Ans) 166. Which of the following is diffusion limited - O2 - CO2 - O2 during exersise (ans) - N2O 167. Which of the following causes decreased Po2 ? - anemia - cyanide poisoning - hypoxic hypoxia (ans) 168. Onset of puberty is due to : - increased estrogen receptors on ovary - increased sensitivity of hypothalamus to estrogens - pulsatile GnRH from the pituitary (Ans) 169. EEG production is due to the following center in brain : - reticular formation - brainstem - medulla - hippocampus (Ans) ? 170. A patient suffers stroke following which he somatosensory loss, asteriognosis . . . . . ? which area involved : - Broadmans area 3,2 - Broadman area 1 - area 5

An epidemiologic study is performed to determine potential risk factors for development of penile squamous intraepithelial neoplasia. It is observed that persons who develop this disease are elderly men. The medical histories of these men are reviewed. Which of the following diseases is most likely to be found to preced...e development of penile neoplasia in these men?

A Phimosis B Herpes simplex virus infection C Lichen simplex chronicus D Balanitis xerotica obliterans E Epispadias

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