SUSPENSI KLORAMFENIKOL PALMITAT

I. A.

Monografi Bahan Rumus Molekul C27H42Cl2N2O6 B. Sinonim D-t eo-!-"-2,2-#iklo o-N-$%-&i# oksi-'-!&i# oksi (+lmit+t. C. ,eme i+n B+&+n Se -uk H+-lu , &+lus se(e ti lem+k, (uti&. -+u lem+&. &+m(i ti#+k -e +s+. D. /el+ ut+n 0i#+k l+ ut +i . mu#+& l+ ut #+l+m +seton #+n #+l+m klo o)o m. l+ ut #+l+m ete . +1+k suk+ l+ ut #+l+m et+nol. s+n1+t suk+ l+ ut #+l+m &eks+n+. 2. 3nkom(+ti-ilit+s 4. ,en5im(+n+n D+l+m 6+#+& te tutu( +(+t. !+nonim, 1775" metil"-(-nit o)enetil* +set+mi#+ 'BM = 561,54

II. A.

Formulasi 4o mul+ St+n#+ Sus(ensi klo +m)enikol /om(osisi8 0i+( 5 ml men1+n#un18 C&lo +m(&eni9oli ,+lmit+s set+ + #en1+n C&lo +m(&eni9olum 125 m1 C+ -o:5met&5l9ellulosum N+t i9um ,ol5so -+tum-<; , o(5len1l59olum Si u(us Sim(le: A=u+ #estil+t+, &in11+ Dosis C+t+t+n 8 > : se&+ i 1 sen#ok t&e 8 1. ,+#+ etiket &+ us ?u1+ te te +8 +. -. 2. /eset+ ++n klo +m)enikol D+lu+ s+ 1,74 1 +m klo +m)enikol (+lmit+t set+ + #en1+n le-i& ku +n1 1 1 +m klo +m)enikol 5; 25 1 5 m1 m1 1 +m ml

1,5 1 +m

,en5im(+n+n8 D+l+m 6+#+& te tutu( +(+t, te lin#un1 #+ i 9+&+5+.

B. Sus(ensi 6; ml /lo +m)enikol C+ -o:5met&5l9ellulosum N+t i9um ,ol5so -+tum-<; , o(5len1l59olum Si u(us Sim(le: A=u+ #estil+t+, &in11+ 4 : se&+ i 1; ml. C. 1.

Des+in 4o mul+ 2,61 1 +m 6;; m1 >;; m1 12 1< 6; 1 +m 1 +m ml

Dosis 8 An+k #i-+6+& 1 t&8 > : se&+ i 2,5 ml. usi+ 1-5 t&8 4 : se&+ i 5 ml. #i+t+s 5 t&8

Al+s+n ,emili&+n B+&+n C+ -o:5met&5l9ellulosum N+t i9um C+ -o:5met&5l9ellulos+ n+t ium +#+l+& 1+ +m n+t ium #+ i (ol59+ -o:5met&5l ete selulos+, men1+n#un1 ti#+k ku +n1 #+ i 6,5 @ #+n ti#+k le-i& #+ i 7,5 @ n+t ium !N+" #i&itun1 te &+#+( A+t 5+n1 tel+& #ike in1k+n. ,eme i+n 8 Se -ukB1 +nul, (uti& s+m(+i k em, &i1 osko(ik. /el+ ut+n8 Mu#+& te #is(e si #+l+m +i mem-entuk l+ ut+n koloi#+l ti#+k l+ ut #+l+m et+nol #+l+m ete #+n #+l+m (el+ ut o 1+nik l+in. C+#+& #+n ,en5im(+n+n8 D+l+m 6+#+& te tutu( +(+t. 2. ,ol5so -+t ,ol5so -+tum-<; <; +#+l+& este ole+t #+ i so -itol #+n +n&i# i#+ 5+n1 -e ko(olime is+si #en1+n le-i& ku +n1 2; molekul etilen+ oksi#+ untuk ti+( molekul so -itol #+n +n&i# i#+ so -itol. ,eme i+n 8 C+i +n se(e ti min5+k, ?e ni& -e 6+ n+ kunin1 mu#+ &in11+ 9okl+t mu#+. -+u k&+s lem+&. +s+ (+&it #+n &+n1+t. /el+ ut+n8 s+n1+t mu#+& l+ ut #+l+m +i , l+ ut+n ti#+k -e -+u #+n ( +ktis ti#+k -e 6+ n+. l+ ut #+l+m et+nol, #+l+m etil +set+t. ti#+k l+ ut #+l+m min5+k mine +l. ,en5im(+n+n 8 #+l+m 6+#+& 5+n1 te tutu( +(+t >. , o(5len1l59ol , o(5len1l59ol men1+n#un1 ti#+k ku +n1 #+ i 77, 5@ C>H<O2. ,eme i+n8 C+i +n kent+l ?e ni& ti#+k -e 6+ n+. +s+ k&+s. ( +ktis ti#+k -e -+u. men5e +( +i (+#+ u#+ + lem-+-. /el+ ut+n8 #+(+t -e 9+m(u #en1+n +i , #en1+n +seton, #+n #en1+n klo o)o m. l+ ut #+l+m ete #+n #+l+m -e-e +(+ min5+k esensi+l. tet+(i ti#+k #+(+t -e 9+m(u #en1+n min5+k lem+k.

,en5im(+n+n8 D+l+m 6+#+& te tutu( +(+t. 4. Si u(us Sim(le: ,em-u+t+n8 l+ utk+n 65 -+1i+n s+k+ os+ #+l+m l+ ut+n metil (+ +-en ;, 25 @ -BD se9uku(n5+ &in11+ #i(e ole& 1;; -+1i+n si u(. ,eme i+n 8 9+i +n ?e ni& ti#+k -e 6+ n+. ,en5im(+n+n 8 #+l+m 6+#+& te tutu( +(+t #item(+t se?uk. D. /lo +m)enikol ,ol5so -+tum-<; , o(5len1l59olum Si u(us Sim(le: A=u+ #estil+t+, &in11+ 2. C+ + /e ?+ CMC-N+ 6;; m1 #ikem-+n1k+n #+l+m +i (+n+s 5+n1 te se#i+ !F 15 menit" /lo +m)enikol (+lmit+t 2,61 #i1e us s+m(+i &+lus #it+m-+& ( o(ilen1likol 12 1 se#ikit #emi se#ikit s+m(+i &omo1en #i+t+m-+& t6een <; +#uk s+m(+i &omo1en. /e#+l+m 9+m(u +n klo +m)enikol #im+sukk+n CMC-N+ s+m-il #i+#uk kemu#i+n #it+m-+&k+n si u(us sim(le: 1< 1 M+sukk+n #+l+m 6+#+& III. A. B. C. D. 2. 4. H. H. 3. Evaluasi Giskosit+s Golume se#iment+si Homo1enit+s /onsistensi !mu#+& ti#+kn5+ #itu+n1" /ese +1+m+n k+n#un1+n !43" Golume ,en#is(e si+n kem-+li Iku +n ,+ tikel Si)+t +li ,enim-+n1+n Sus(ensi klo +m)enikol 6; ml 1,74 E ;,125 = ;,2175 1B 5ml E 6; ml = 5;m1 B5 ml E 6; ml = 25m1 B5 ml E 6; ml = 1 1 B 5 ml E 6; ml = 1,5 1 B5 ml E 6; ml = 5 ml B5 ml E 6; ml = 2,61 1 +m = 6;; m1 = >;; m1 = 12 = 1< 1 +m 1 +m C+ -o:5met&5l9ellulosum N+t i9um

= +# 6; ml