Tablet Wt variation

Enter the wt of the tablets

S.No

Individual wt of Tablet

% of Wt variation
*100

1
2
3

496
498
501

-0.780156031
-0.380076015
0.220044009

507

1.420284057

505

1.020204041

500

0.020004001

495

-0.980196039

496

-0.780156031

9
10

504
500

0.820164033
0.020004001

11

500

0.020004001

12

495

-0.980196039

13

505

1.020204041

14
15
16
17
18
19
20
total wt

503
497
496
496
504
497
503
9998

0.620124025
-0.580116023
-0.780156031
-0.780156031
0.820164033
-0.580116023
0.620124025
9.13714E-14

AVG wt

499.9

4.56857E-15

Tablet Wt variation

Developers
SRINIVAS COLLGE OF PHARMACY, MANGALORE
575001
saieshphaldesai12@gmail.com
Developed by Saiesh Phaldesai

Instructions

Enter the values in "E" column (Light Pink boxes)

Get the report from yellow colour column

Report of % of wt variation of 20 tablets

IP & USP LIMITS

Wt of the tablet
More than 325mg
325-130mg
less than 130mg

% of deviation
10
7.5
5

DEVELOPED BY: SAIESH P. PHALD

MAIL ME @ saieshphaldesai1

EVALUATION FORMULARS
BY: SAIESH P. PHALDESAI

B.PHARMA, M.PHARMA

@ saieshphaldesai12@gmail.com

Developed By : Saiesh phaldesai

SRINIVAS COLLGE OF PHARMACY, MANG
saieshphaldesai12@gmail.com

Instructions
1 Enter the values in blue colored boxes
2 Get report in yellow coloured box

REPORT

S.No
1
2
3
4
5
6
AVG

Developed By : Saiesh phaldesai

SRINIVAS COLLGE OF PHARMACY, MANGALORE
saieshphaldesai12@gmail.com

Test for Friability

Intial Weight
Final Weight
% Friability

4.4
4.6
-4.545

Disintegration Time
Time (Sec/Min)
89
54
34
43
23
75
53

Creative Head And Work Function By Saiesh Phaldesai :- @ saieshphaldesai@yahoo

BCP Software : Saiesh Phaldesai

Srinivas College of Pharamacy, Mangalore. Develop

S.No

Concentration (ug/ml)
1
2
3
4
5
6

Absorbance
0
2
4
6
8
10

Calibration Curve (R2)

SLOPE
Unknown Absorbance
Unknown Concentration

Wt of API Taken
Dilution factor
Volume of withdrawn
Volume of DissolutionMedium

0
0.118
0.22
0.322
0.422
0.522
0.99918159
0.051
0.424
8.31372549

200
100
5
100

ldesai :- @ saieshphaldesai@yahoo.co.in and saieshphaldesai12@gmail.com

ENTER VALUES IN COLURED COLUMN

amacy, Mangalore. Developed by : saieshphaldesai12@gmail.com

S.No

Time

ABS

Amt
% CDR
in Medium

1
2
3
4
5
6

5
10
15
20
25
30

0.049
0.085
0.174
0.298
0.365
0.137

4.80392157
8.33573529
17.0653922
29.2307843
35.8140196
13.4789706

7
8
9
10

35
40
45
50

0.668

65.5445098
0.08705882
0.08705882
0.08705882

* No Dilution Factor Enter 1

ENTER VALUES IN COLURED COLUMNS

Calibration Curve
0.6
R = 0.9992

0.5
0.4
0.3

Calibration Curve

0.2
0.1
0
0

10

12

F1

F2

F3

F4

Time

Reference
60
120
180
240
300
360

N=

80
81.88
83.11
86.31
90.04
94

Test

Rt-Tt
70
80
85
89
89
97

Rt sum
6

515.34

Similarity factor(50-100)=

66.56983 (F2)

Difference factor (0-15)=

3.977956 (F1)

(Rt-Tt)2
10
1.88
-1.89
-2.69
1.04
-3
0
0
0
0
0

|Rt-Tt|
100
10
3.5344
1.88
3.5721
1.89
7.2361
2.69
1.0816
1.04
9
3
0
0
0
0
0
0
0
0
0
0
(Rt-Tt)2 sum |Rt-Tt| sum
124.4242
20.5

This is used for the Performance differen

between
(Eg. Differnce of Innovator Product to Gen

If the value More than 50 it is similar (f2).

If the value is Less than 50 it is Dissimilar

Enter the Time Points

Developed By :Saiesh Phaldesai

Srinivas College of Pharmacy - mangal

Enter the values

%CDR

Time (Hr)
0

Log Time

SQRT Time
0

saieshphaldesai12@gmail.com
Log % Release

% Cumula Release
0

0.699

2.236

13.09

1.117

15

1.176

3.873

18.83

1.2749

30

1.477

5.477

22.23

1.3469

45

1.653

6.708

27.6

1.4409

60
90

1.778
1.954

7.746
9.487

39.94
45.94

1.6014
1.6622

120

2.079

10.954

54.36

1.7353

150

2.176

12.247

61.99

1.7923

180

2.255

13.416

81.75

1.9125

210

2.322

14.491

88.79

1.9484

240

2.380
#NUM!
#NUM!
#NUM!
#NUM!

15.492
0.000
0.000
0.000
0.000

96.83

Zero order
0.373278

1.9860
#NUM!
#NUM!
#NUM!
#NUM!
Peppas
#NUM!

0.9799

#NUM!

K0(Slope)

Report

R2

0.3733

% of Cumulative Drug Release

Zero order Release

100
80
60

Zero order Release

40
20
0
0

2.100

12

Time (h)

16

Peppas Model

20

24

Peppas Model
Log % of Release

1.800
1.500

y = 0.814x + 0.1052
R = 0.964

1.200
0.900
0.600
0.300

-0.500

0.000
-0.200

0.100

0.400

0.700

1.000

1.300

Log t
The End

Developed By :Saiesh Phaldesai

Srinivas College of Pharmacy - mangalore

aieshphaldesai12@gmail.com
% Drug remaining
100

Log % Drug remaining

2

86.91

1.939

Instructions

81.17

1.909

77.77

1.891

72.4

1.860

60.06
54.06

1.779
1.733

1. Enter the values in Pink color boxes (Time and % Cumulativ

2. Check the System of Release by R 2 Values.
Which is near to 0.999 which follows the same system of r
3. Get the Graphs from down.

45.64

1.659

Order

38.01

1.580

18.25

1.261

11.21

1.050

3.17
100
100
100
100
Higuichi

0.501
2.000
2.000
2.000
2.000
First Order
-0.005

Zero Order
First Order
Higuichi Model
Peppas Model

0.9619

Graphs
Time vs Drug Release
Time vs log % Drug Remaining
SQRT Time vs % Drug Release
log Time vs log % Drug Release
Graphs (Diplayed at down)

0.8701
K1

0.012

Log %Cumulative remain to reelase

2.5

y = -0.005x + 2.0739
R = 0.8701

First Order

1.5

0.5

0
0

100

12
Time (h)

16

Higuchi Model

20

24

% Cumulative drug release

80

y = 6.1644x
R = 0.9619

60

40

Higuchi Model

20

0
0 0.5 1 1.5 2 2.5 3 3.5 4 4.5 5 5.5 6 6.5 7 7.5 8t
8.5 9 9.51010.51111.51212.51313.51414.51515.516

in Pink color boxes (Time and % Cumulative Drug Release)

m of Release by R 2 Values.
o 0.999 which follows the same system of release

Graphs

me vs Drug Release
me vs log % Drug Remaining
RT Time vs % Drug Release
Time vs log % Drug Release

aphs (Diplayed at down)

-0.005x + 2.0739
R = 0.8701

First Order

y = 6.1644x - 6.5174
R = 0.9619

Higuchi Model

1515.51616.5

Edit your Time Points, Fomulation Codes and Release Profile as per yo
Time
0
1
2
3
4
5
6
7
8
9
10
11
12

F1

F2

1
2
3
4
5
6
7
8
9
10
11
12
13

1
4
3
6
5
6
7
10
9
10
11
14
18

% Cumulative Drug Release

F3
F4
F5
1
6
3
9
5
6
9
10
14
10
18
14
20

1
6
3
14
5
6
9
18
14
10
21
14
26

1
6
3
14
5
6
9
18
14
10
21
14
26

BCP Software

F6

F7

1
6
3
14
5
6
9
25
14
10
21
14
29

8
10
3
14
5
6
9
25
29
10
21
39
29

Developed By : SAIESH
SRINIVAS College of Ph
SAIESHPHALDESAI12@gmail.com

F8

F9

8
10
3
14
30
6
9
25
29
10
21
39
29

8
10
3
14
5
6
9
46
29
10
21
39
59

% Cumulative drug release

nd Release Profile as per your Study

100

80

60

40

20

0
0

Developed By : SAIESH PHALDESAI

SRINIVAS College of Pharmacy -MANGALORE
SAIESHPHALDESAI12@gmail.com

Time (h)

10

12

F1
F2
F3
F4
F5
F6
F7
F8
F9

12

14

% Cumulative drug release

Time

F1
0
1
2
3
4
5
6
7
8
9
10
11
12

F2

F3
0

F4
0

F5
0

45

BCP Software

F7
0

F8
0

100

F9
0

% Cumulative drug release

F6

80

60

40

20

34

Time (h)

Zero Order
Developed By : SAIESH PHALDESAI
Srinivas College of Pharmacy - Bharathinagara-571422
saieshphaldesai12@gmail.com

F1
F2
F3
F4
F5
F6
F7
F8
F9

Time (h)

10

12

14

Log %Cumulative remain to reelase

Time
1
2
3
4
5
6
7
8
9
10
11
12

F1

F2

F3

F4

F5

F6

1.836
1.829
1.796
1.76
1.705
1.69
1.597
1.456
1.753
1.738
1.683
1.625

1.896
1.838
1.808
1.779
1.753
1.738
1.683
1.625
1.753
1.738
1.683
1.625

1.9
1.876
1.864
1.848
1.832
1.816
1.775
1.718
1.753
1.738
1.683
1.625

1.942
1.933
1.917
1.906
1.898
1.876
1.846
1.828
1.753
1.738
1.683
1.625

1.81
1.778
1.756
1.678
1.566
1.507
1.312
1.075
1.753
1.738
1.683
1.625

1.814
1.784
1.774
1.71
1.641
1.462
1.407
1.135
1.753
1.738
1.683
1.625

BCP Software

Developed By : SAIESH PH
Srinivas College of Pharm
saieshphaldesai12@gmail.com

F7

F8

1.866
1.848
1.824
1.78
1.718
1.696
1.632
1.548
1.753
1.738
1.683
1.625

1.938
1.931
1.921
1.903
1.887
1.874
1.839
1.821
1.753
1.738
1.683
1.625

F9
1.888
1.868
1.853
1.835
1.825
1.803
1.76
1.708
1.753
1.738
1.683
1.625

Log %Cumulative remain to relase

2.2

1.8

1.6

1.4

1.2

1
0

1st order
Developed By : SAIESH PHALDESAI
Srinivas College of Pharmacy - Bharathinagara-571422
saieshphaldesai12@gmail.com

Time (h)

F1

F2
F3
F4
F5
F6
F7
F8
F9

Log % Cumulative drug release

LOG T
0
0.301
0.477
0.602
0.6989
0.778
0.845
0.903

F1

F2

F3

F4

F5

1.496
1.512
1.572
1.637
1.692
1.707
1.781
1.853
1.637
1.667
1.714
1.762

1.33
1.492
1.552
1.6
1.637
1.667
1.714
1.762
1.637
1.667
1.714
1.762

1.312
1.394
1.43
1.471
1.51
1.538
1.61
1.68
1.637
1.667
1.714
1.762

1.096
1.154
1.246
1.29
1.32
1.39
1.47
1.51
1.637
1.667
1.714
1.762

1.548
1.602
1.634
1.719
1.801
1.831
1.9
1.945
1.637
1.667
1.714
1.762

BCP Software

F6

F7

F8

1.542
1.592
1.608
1.687
1.75
1.851
1.872
1.936
1.637
1.667
1.714
1.762

1.423
1.469
1.523
1.599
1.677
1.701
1.757
1.811
1.637
1.667
1.714
1.762

1.125
1.168
1.219
1.3
1.359
1.4
1.491
1.528
1.637
1.667
1.714
1.762

F9
1.357
1.418
1.457
1.501
1.52
1.562
1.627
1.69
1.637
1.667
1.714
2

Log % Cumulative drug release

1.8

1.6

1.4

1.2

1
0

0.2

0.4

0.6

Log t

Peppas

Developed By : SAIESH PHALDESAI

Srinivas College of Pharmacy - Bharathinagara-571422
saieshphaldesai12@gmail.com

F1

F2

F3

F4

F5

F6

F7

F8

F9

0.8

SQRT

F1

F2

1
1.41
1.73
2
2.23
2.44
2.64
2.82
2.23
2.44
2.64
2.82

31.34
32.54
37.35
42.35
49.23
50.88
60.41
71.36
32.1
34.51
40.4
47.81

F3
0

F4

F5
0

21.36
20.45
12.53
31.08
24.8
14.27
35.68
26.91
17.62
39.86
29.57
19.37
43.37
32.1
20.8
45.35
34.51
24.86
51.79
40.4
29.42
57.83
47.81
32.63
32.1
32.1
32.1
34.51
34.51
34.51
40.4
40.4
40.4
47.81
47.81
47.81
% Cumulative drug release

F6
0

35.38
39.96
43.01
52.33
63.18
67.82
79.49
88.11
32.1
34.51
40.4
47.81

34.83
39.12
40.54
48.68
56.26
71.03
74.46
86.34
32.1
34.51
40.4
47.81

Higuchi

BCP Software

Developed By : SAIESH
SRINIVAS College of Ph
saieshphaldesai12@gmail.com

F8

F9

100

26.49
29.46
33.38
39.75
47.71
50.29
57.14
64.68
32.1
34.51
40.4
47.81

13.32
14.74
16.56
19.94
22.86
25.1
30.95
33.74
32.1
34.51
40.4
47.81

22.74
26.18
28.67
31.67
33.1
36.51
42.4
48.94
32.1
34.51
40.4
47.81

90

% Cumulative drug release

F7

80
70
60
50
40
30
20
10
0
0

Higuchi
Developed By : SAIESH PHALDESAI
SRINIVAS College of Pharmacy MANGALORE
saieshphaldesai12@gmail.com

0.5

1.5

2.5

F1
F2
F3
F4
F5
F6
F7
F8
F9
2.5