Advantageous for consumers of CGA is its proposed capability to modulate glucose

in the bloodstream following the intake of carbohydrate-based meals. Minimization

of glucose output as a major facilitator in healthy fat loss has all things considered
long been known therefore the low simple-carbohydrate mandate most diets
espouse. !n one study researchers "#$ investigated whether %vetol could decrease
post-prandial "following meals$ blood glucose concentration in humans. !n their
study #& women and men aged between #' and () were submitted to a glucose
tolerance test before and after supplementation with %vetol "*))mg of %vetol in
three daily doses - +))mg per day - over a ,) day period$. -hysical activity levels
and diet for all participants remained unchanged during this time period. After the
,)-day supplementation period it was found that post-load glycaemia "or blood
glucose levels following a meal$ had decreased signi.cantly compared to the post-
load glycaemia obtained before the supplementation/ ++0 of participants also
e1perienced an average improvement of ,'0 in blood glucose concentration
following meals. 2or ten participants glucose tolerance was highly and signi.cantly
decreased after supplementing with the %vetol when compared to the glucose
tolerance readings obtained before they had supplemented with %vetol. 2inally an
average loss of appro1imately 3lbs bodyweight was noted among all group
members irrespective of their unchanged diet and e1ercise pattern.
Svetol and Body Mass
!n a double-blind placebo-controlled clinical study which assessed the potency of
%vetol supplementation on weight loss "*$ researchers discovered a substantial
4ody Mass !nde1 "4M!$ reduction among participants in comparison to the study5s
control group.
!n this study &) volunteers of both se1es aged from #6 to (& and with 4M!5s
surpassing *& "placing them in the overweight category$ were split into two
randomized groups7 a control group of *) participants who received a placebo and a
treated group of 3) who were given *))mg of %vetol brand Green Co8ee 4ean
91tract "GC49$ two times a day for +) days with main meals "thus each %vetol
subject received the desired daily amount of CGA5s7 ,))mg$. 2or each subject - both
control and treated - changes in body weight 4M! and Muscle Mass:2at Mass
"MM:2M$ ratio were recorded at the study5s commencement and completion.
After the +)-day treatment period the %vetol subjects were found to have favorably
reduced their bodyweight by an average of &.(0 ",.6(kg:#).6+lb$ whereas the
control group who had received *))mg of maltode1trin in place of the %vetol twice
a day showed a mean lowering of *.,&kg:&.,)lb. MM:2M ratio had also signi.cantly
improved for all treated participants.
!t was determined that %vetol is able to e1acerbate the e8ects of a bland low calorie
diet in overweight subjects a .nding which say the researchers could be e1plained
by a boost in the intake of fatty deposits and an o8setting of their accumulation
through %vetol brand Green Co8ee 4ean 91tract "GC49$ supplementation.
Bioavailability of CGA
As revealed in the above two studies Chlorogenic Acids "CGAs$ appear to
successfully modulate blood glucose levels to encourage body fat utilization to
e8ectively manage body weight. !n a newer study researchers "3$ sought to gauge
the precise bioavailability of CGAs in human subjects by evaluating the
pharmacokinetic pro.le of CGAs in blood plasma and urine of #) healthy adults ".ve
male and .ve female$ for eight hours following the intake of a deca8einated co8ee
e1tract containing #()mg of CGA. After acute ingestion of the co8ee e1tract each
subject was to be tested for bio-available degrees of CGA compounds and
metabolites. !t was found out that over 3)0 of the active CGA compounds including
metabolites for e1ample &-C;A and ca8eic acid ingested were recovered in plasma
"with peak levels from ).& to ' hours after treatment$ and indenti.ed in urine
following treatment. <his research which revealed that the major CGA compounds
found in green co8ee are highly absorbed and metabolized in humans
demonstrated for the .rst time the high bioavailability of green co8ee even
considering the relatively low e1perimental doses of #()mg that were given.
<his research demonstrates that the Chlorogenic Acids found in Green Co8ee 4ean
91tract are taken up by and e8ectively absorbed into the body.
A Dosage Study
An additional study e1amined the e=cacy and safety of high and low dose CGA
supplementation on weight and body mass reduction among #+ overweight adult
subjects aged **-,+ "average 4M! at the study5s commencement was *'.**$. !n a
double-blind placebo-controlled linear dose ** week crossover study each subject
received either #)&)mg or ())mg of the green co8ee bean e1tract "GC49$ or a
placebo in separate si1-week treatment periods "followed by a two-week >washout5
period to prevent preceding treatments in?uencing the results$. 4ody weight body
fat percentage and 4M! were measured to determine any positive e8ects. @o
dietary changes were made by any subject during this study. Consistent with
.ndings from other studies into CGA supplementation all subjects were found to
have lowered their 4M! "-*.6*kg:M*$ body weight "a mean reduction of 'kg or
#(.+,lb$ and body fat percentage ",.,0 on average$. All participants reported no
negative e8ects associated with the green co8ee e1tract consumption.
<he researchers determined that the product tested may be an Ae8ective
nutraceutical in lessening weight in pre-obese adults and may be a cost-e8ective
means of preventing obesity in overweight adults.B
As said before CGA supplementation has been shown to have a marked in?uence
on weight loss through its inhibiting impact on glucose-+-phosphatase which in
turn encourages the liberating of stored fat for energy. <hough several studies5
.ndings supported such an action through human trials further researchers "&$
sought to determine whether a deca8einated green co8ee e1tract "%vetol$ would
inhibit hepatic glucose-+-phosphatase in vitro "studies conducted in laboratory
conditions to isolate an element of an organism from its usual biological conte1t$. !n
this study three concentrations were tested7 the eCuivalent of #&(mg 3#&mg and
,(*mg "eCuivalent to the daily recommended %vetol intake$ of %vetol per liter of
solution. After the incubation of human liver microsomes "with or without %vetol$ it
was determined that %vetol competitively inhibited glucose-+-phosphatase. <he
researchers determined that their observed results are primarily associated with
post meal blood glucose regulation and the fat burning action %vetol has
demonstrated in other studies.