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  • NCGS Study Data on Serum Cholesterol Levels Over Time

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    Anubhav Aggarwal
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    The data are from the National Cooperative Gallstone Study (NCGS), where one of the major interests was to study the safety of the drug chenodiol for the treatment of cholesterol gallstones In this study, patients were randomly assigned to high-dose (750 mg per day), low-dose (375 mg per day), or placebo. This dataset consists of a subset of data on patients who had floating gallstones and who were assigned to the high-dose and placebo groups. In the NCGS it was suggested that chenodiol would dissolve gallstones but in doing so might increase levels of serum cholesterol. As a result, serum cholesterol (mg/dL) was measured at baseline and at 6, 12, 20, and 24 months of follow-up. Many cholesterol measurements are missing because of missed visits, laboratory specimens were lost or inadequate, or patient follow-up was terminated.

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    Data on serum cholesterol from the National Cooperative Gallstone Study (NCGS)

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    The data are from the National Cooperative Gallstone Study (NCGS), where one of the major interests was to study the safety of the drug chenodiol for the treatment of cholesterol gallstones In this study, patients were randomly assigned to high-dose (750 mg per day), low-dose (375 mg per day), or placebo. This dataset consists of a subset of data on patients who had floating gallstones and who were assigned to the high-dose and placebo groups. In the NCGS it was suggested that chenodiol would dissolve gallstones but in doing so might increase levels of serum cholesterol. As a result, serum cholesterol (mg/dL) was measured at baseline and at 6, 12, 20, and 24 months of follow-up. Many cholesterol measurements are missing because of missed visits, laboratory specimens were lost or inadequate, or patient follow-up was terminated.

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    © All Rights Reserved
    Download as TXT, PDF, TXT or read online from Scribd
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    64 views3 pages

    NCGS Study Data on Serum Cholesterol Levels Over Time

    Uploaded by

    Anubhav Aggarwal
    The data are from the National Cooperative Gallstone Study (NCGS), where one of the major interests was to study the safety of the drug chenodiol for the treatment of cholesterol gallstones In this study, patients were randomly assigned to high-dose (750 mg per day), low-dose (375 mg per day), or placebo. This dataset consists of a subset of data on patients who had floating gallstones and who were assigned to the high-dose and placebo groups. In the NCGS it was suggested that chenodiol would dissolve gallstones but in doing so might increase levels of serum cholesterol. As a result, serum cholesterol (mg/dL) was measured at baseline and at 6, 12, 20, and 24 months of follow-up. Many cholesterol measurements are missing because of missed visits, laboratory specimens were lost or inadequate, or patient follow-up was terminated.

    Copyright:

    © All Rights Reserved
    Download as TXT, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 3

    Data on serum cholesterol from the National Cooperative Gallstone Study (NCGS).

    Source: Table 2 (page 657) of Wei and Lachin (1984).


    Reproduced with permission of the American Statistical Association.
    Reference: Wei, L.J. and Lachin, J.M. (1984). Two-Sample Asymptotically Distribu
    tion-Free
    Tests for Incomplete Multivariate Observations. Journal of the American Statisti
    cal Association, 79, 653-661.
    Description:
    The data are from the National Cooperative Gallstone Study
    (NCGS), where one of the major interests was to study the safety
    of the drug chenodiol for the treatment of cholesterol gallstones
    In this study, patients were randomly assigned to high-dose (750 mg per
    day), low-dose (375 mg per day), or placebo. This dataset consists of
    a subset of data on patients who had floating gallstones and who were
    assigned to the high-dose and placebo groups.
    In the NCGS it was suggested that chenodiol would dissolve gallstones
    but in doing so might increase levels of serum cholesterol. As a result,
    serum cholesterol (mg/dL) was measured at baseline and at 6, 12, 20, and
    24 months of follow-up. Many cholesterol measurements are missing because
    of missed visits, laboratory specimens were lost or inadequate, or
    patient follow-up was terminated.
    Variable List:
    Treatment Group (1=High dose chenodiol, 2-Placebo), Subject ID,
    Response at Baseline, Response at Month 6, Response at Month 12,
    Response at Month 20, Response at Month 24.
    Note: Response = Serum cholesterol (. denotes missing value).
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1

    1
    2
    3
    4
    5
    6
    7
    8
    9
    10
    11
    12
    13
    14
    15
    16
    17
    18
    19
    20
    21
    22

    178
    254
    185
    219
    205
    182
    310
    191
    245
    229
    245
    240
    234
    210
    275
    269
    148
    181
    165
    293
    195
    210

    246
    260
    232
    268
    232
    213
    334
    204
    270
    200
    293
    313
    281
    252
    231
    332
    180
    194
    242
    276
    190
    230

    295
    278
    215
    241
    265
    173
    290
    227
    209
    238
    261
    251
    277
    275
    285
    300
    184
    212
    250
    276
    205
    249

    228
    245
    220
    260
    242
    200
    286
    228
    255
    259
    297
    307
    235
    235
    238
    320
    231
    217
    249
    278
    217
    240

    274
    340
    292
    320
    230
    193
    248
    196
    213
    221
    231
    291
    210
    237
    251
    335
    184
    205
    312
    306
    238
    194

    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    1
    2
    2
    2
    2
    2
    2
    2
    2
    2
    2
    2
    2
    2
    2
    2
    2
    2
    2
    2
    2

    23
    24
    25
    26
    27
    28
    29
    30
    31
    32
    33
    34
    35
    36
    37
    38
    41
    42
    43
    44
    45
    46
    48
    49
    50
    51
    52
    53
    54
    55
    56
    57
    58
    59
    60
    61
    62
    63
    64
    65
    1
    2
    3
    4
    5
    6
    7
    8
    9
    10
    11
    12
    13
    14
    15
    16
    17
    18
    19
    20

    212
    243
    259
    202
    184
    238
    263
    144
    220
    225
    224
    307
    313
    231
    206
    285
    250
    175
    201
    268
    202
    260
    209
    197
    248
    212
    276
    163
    239
    204
    247
    195
    228
    290
    284
    217
    209
    200
    227
    193
    251
    233
    250
    141
    418
    229
    271
    312
    194
    211
    205
    191
    249
    301
    201
    251
    277
    294
    212
    230

    224
    271
    279
    214
    192
    272
    283
    226
    272
    260
    273
    252
    300
    252
    177
    291
    269
    214
    219
    296
    186
    268
    207
    218
    262
    253
    326
    179
    243
    203
    211
    250
    228
    264
    288
    231
    200
    261
    247
    189
    262
    218
    258
    143
    371
    218
    289
    323
    220
    232
    299
    248
    217
    270
    214
    257
    242
    313
    236
    315

    246
    304
    296
    192
    205
    297
    248
    261
    222
    253
    242
    316
    313
    267
    194
    291
    .
    .
    220
    314
    253
    .
    167
    .
    .
    225
    304
    199
    265
    198
    225
    272
    279
    260
    268
    276
    269
    264
    .
    .
    239
    230
    258
    157
    363
    228
    270
    318
    214
    189
    278
    283
    236
    282
    247
    237
    249
    295
    235
    300

    271
    273
    262
    239
    253
    282
    334
    227
    246
    202
    274
    258
    317
    299
    194
    268
    .
    .
    .
    330
    .
    .
    .
    .
    .
    .
    .
    .
    .
    .
    .
    .
    .
    .
    261
    257
    233
    300
    .
    232
    234
    251
    286
    162
    384
    244
    296
    383
    256
    230
    259
    268
    266
    287
    274
    266
    293
    295
    272
    305

    256
    318
    283
    172
    217
    251
    271
    283
    253
    265
    .
    283
    397
    .
    212
    260
    .
    .
    .
    .
    .
    .
    .
    .
    .
    .
    .
    .
    .
    .
    .
    .
    .
    .
    .
    .
    .
    .
    220
    211
    248
    273
    240
    169
    387
    179
    346
    310
    204
    231
    266
    233
    235
    268
    224
    .
    306
    271
    287
    341

    2
    2
    2
    2
    2
    2
    2
    2
    2
    2
    2
    2
    2
    2
    2
    2
    2
    2
    2
    2
    2

    21
    22
    23
    24
    25
    26
    27
    28
    29
    30
    31
    32
    33
    34
    37
    38
    44
    45
    46
    47
    48

    206
    246
    245
    179
    165
    262
    212
    285
    166
    179
    298
    238
    172
    191
    282
    213
    171
    242
    197
    230
    373

    242
    205
    192
    202
    142
    274
    216
    292
    171
    206
    280
    267
    180
    208
    282
    249
    188
    268
    224
    228
    309

    236
    249
    215
    194
    188
    245
    228
    300
    166
    214
    280
    269
    216
    162
    .
    219
    .
    .
    214
    266
    332

    239
    225
    214
    239
    192
    275
    221
    319
    186
    189
    328
    268
    183
    218
    .
    209
    .
    .
    .
    .
    .

    .
    236
    242
    234
    200
    278
    223
    277
    220
    250
    318
    280
    .
    206
    .
    .
    .
    .
    .
    .
    .

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