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PRACTICAL-12

Aim: To prepare stable oral suspension of given API using different

structured vehicles and to study the effect on stability of suspension.

Formula: Each 5ml contains Barium sulphate (calcium carbonate) 1.56g

Base

q.s.

Batch size: 50 ml.

Packaging: Narrow mouth glass bottle with metal screw cap.
Formula:
Ingredients

Quantity given Quantity for 50 ml

Role of each
ingredients

Dummy drug (CaCO3)

31.25 gm

15.62 ml

Drug

Kollidon 90 F(PVP)

1.56 gm

0.78 ml

Suspending
agent

Sodium carboxy methyl 0.125 gm

cellulose

0.062 ml

Flocculating
agent

Sodium bisulfite

0.125 gm

0.062 ml

Antioxidant

Methylparaben

0.02 ml

0.1 ml

Preservative

Propylparaben

0.02 ml

0.01 ml

Preservative

Water

100 ml (up to)

50 ml

Vehicle

Total

133 g

66.63 ml

Procedure:

1. Method of preparation:
All the ingredients were weighed accurately.
Calcium carbonate, sodium bisulfite and kollidon 90 F (PVP) were passed
through sieve no. 20 and mixed thoroughly in a mortar.

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Observation table:
1) Organoleptic properties:
Structured vehicle

Color

Odor

2) PH:
PH

excipients

3) Sedimentation parameter:
excipient

Sucrose

Time
(min)

Initial
height(cm)
H0

Final height
(cm)Hu

Ratio
(Hu/H0)

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Both the preservatives were dissolved in water.

Small quantity of aqueous phase was added gradually in the mortar with
continuous trituration until a smooth paste was formed.
Then the solution of structured vehicle (sodium carboxy methyl cellulose,
methyl cellulose) or syrup of sucrose, fructose, and dextrose was added and
mixed thoroughly in particular concentration.
Now the remaining amount of water was added with mixed thoroughly and
volume was made up to 100 ml.
The suspension was then evaluated.

Following ingredients were used to prepare structured vehicle:

Sucrose syrup, dextrose syrup, fructose syrup,
Sodium carboxy methyl cellulose (1% - 2% W/W)
Methyl cellulose (1% - 2% W/W)

Evaluation parameters:
1.
2.
3.
4.

Organoleptic properties
pH
Density
Sedimentation parameters
a. Sedimentation volume ratio
b. Sedimentation rate
c. Redispersibility study

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Dextrose

Fructose

Sodium
carboxy
methyl
cellulose

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Conclusion:
In oral suspension formulation uniformity of solid or dispersed phase in
dispersed medium ensured by addition of proper viscosity enhancers
throughout its shelf life.
Dispersed phase can be kept in well distributed form by addition of
various structured vehicles but the viscosity of the formulation should not
affect the pourability of the dosage form.
In oral suspension formulation solid should have minimum sedimentation
and this can be achieved by addition of structured vehicles.
In the present study, attempt is made to prepare stable and pourable oral
suspension with various synthetic and syrup base structured vehicles.
The observation shows that syrup base structured vehicle gives
flocculated suspension which is desirable; it does not form a hard cake
and can be easily redispersed. Methyl cellulose also gives easily
redispersed suspension while Sodium carboxymethyl cellulose form hard
cake and it cannot be easily redispersed.

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Methyl
cellulose

1) Redispersibility:
excipients

No of inversion

2) Density:
Structured vehicle

Density (gm/L)

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