Professional Documents
Culture Documents
REVIEW
Natural Aphrodisiacs
jsm_1521
39..49
Rany Shamloul, MD
Queens UniversityPharmacology, Kingston, Ontario, Canada; Cairo UniversityAndrology and Sexology department,
Cairo, Egypt
DOI: 10.1111/j.1743-6109.2009.01521.x
ABSTRACT
Introduction. The search for a remedy or a prescription that can enhance sexual function and/or treat male erectile
dysfunction has been an obsession throughout known history. Whether it was an Eastern civilization or a Western
one, religious or atheist, mans aspiration for a better or best manhood has been a history-time goal.
Aim. This review will discuss the current research done on the most popular natural aphrodisiacs and examine the
weight of evidence to support or discourage the use of any of these substances to enhance sexual desire and/or function.
Methods. Review of the current evidence on the use of natural substances as aphrodisiacs.
Main Outcome Measures. Efcacy of natural aphrodisiacs in enhancing sexual function in men and women.
Results. There is little evidence from literature to recommend the usage of natural aphrodisiacs for the enhancement
of sexual desire and/or performance. Data on yohimbines efcacy does not support the wide use of the drug, which
has only mild effects in the treatment of psychogenic ED. Although theres a positive trend towards recommending
ginseng as an effective aphrodisiac, however, more in depth studies involving large number of subjects and its
mechanism of action are needed before denite conclusions could be reached. Data on the use of natural aphrodisiacs
in women is limited.
Conclusions. The current body of objective evidence does not support the use of any natural aphrodisiac as an
effective treatment for male or female sexual dysfunctions. Potent men and men with ED will continue the search
for natural aphrodisiacs despite the current disappointing data on their effectiveness. Care should be taken regarding
the fraud addition of sildenal analogues to natural aphrodisiacs. Shamloul R. Natural aphrodisiacs. J Sex Med
2010;7:3949.
Key Words. Natural Aphrodisiacs; Ginseng; Yohimbine
Introduction
40
ED [2]. One of these poems describes natural high
nutritional value treatments, perfumes and even
spices that can enhance mans sexual abilities [1].
In an old Chinese text (2697 to 2595 BC), a
remedy consisting of 22 ingredients is described to
the contemporary emperor who drank it and was
able to mount 1,200 women and achieved immortality [3]. Moving on in history the Romans and
Chinese shared the same aphrodisiac concept (or
truly, misconception) that consuming the animal
genitals can enhance mens sexual function [1].
The ancient Egyptians had their share of aphrodisiacs with several papyri describing many medications for ED including local penile application of
oiled baby crocodile hearts, ingestion of pine, salt,
and watermelon [4,5].
In recent history, the search for the ultimate
aphrodisiac did not stop with hundreds and hundreds of natural and unnatural substances tried. It
was expected that the advent of phosphodiesterase
type 5 inhibitors (PDE5s) and other evidencebased successful oral pharmacotherapy for ED will
lead to less interest in aphrodisiacs. However, the
reverse occurred and a simple Medline search
using the term aphrodisiac between 2000 and
2009 yielded more than 146 citations compared
with that 86 articles between 1990 and 1999, a net
increase of 59%. This may be because of the fact
that the discovery of very successful therapies of
ED may have led to increased expectations of
nding a natural substance that may have similar
effects to PDEs without their known side-effects.
Also, it may be that men requesting aphrodisiacs
are suffering from a mild form of decreased libido,
which cannot be treated with PDEs. Another
important reason is that it seems that some men
seeking aphrodisiacs are normal and potent but
just looking for an unrealistic heightened sexual
satisfaction that they couldnt attain using PDEs,
which only work on men with various degrees of
ED and normal libido.
Because of their huge diversity of chemical
content, there appears to be no known universal
classication of aphrodisiacs. However, a working
classication can be designed to term aphrodisiacs made from natural sources as natural aphrodisiacs whereas others made of synthetic
compounds are called non-natural aphrodisiacs.
Intracavernosal, intra-urethral, and oral PDEs
drugs used for the treatment of ED and synthetic
androgens can all be classied as non-natural
aphrodisiacs. Natural aphrodisiacs can be further
classied into plant aphrodisiacs and nonplant
aphrodisiacs.
J Sex Med 2010;7:3949
Shamloul
This review will discuss the current research
done on the most popular natural aphrodisiacs and
examine the weight of evidence to support or discourage the use of any of them to enhance sexual
desire and/or function.
Natural Aphrodisiacs
Natural Aphrodisiacs
tion drug approved by the Food and Drug Administration (FDA) as a mydriatic. Prior to the advent
of the PDE5s, and owing to its central action as an
a-2 adrenergic antagonist, yohimbine was one of
the few oral pharmacological agents prescribed
for the treatment of ED. Several randomizedcontrolled trials reported various efcacy rates of
yohimbine ranging from 34% to 73% [915]. A
meta-analysis of these trials commented that this
large variability of success rates may be caused by
the difference in the patients ages and the etiology
of ED. Also, it is thought that different methods of
assessment of the degree of ED in these trials may
have impacted the results. In general, yohimbine
may be effective but primarily in patients with
psychogenic ED [16]. More recent studies
reported that a combination therapy of Larginine/yohimbine may yield improvement of
erectile function [17,18]. These studies on Larginine/yohimbine are preliminary and should
not be considered denitive until they are conrmed by larger, more rigorous studies. Sideeffects related to yohimbine include hypertension,
anxiety and palpitations.
Tribulus Terrestris
Tribulus terristrus (TT) is a perennial creeping
herb with a worldwide distribution. This plant has
been used for a long time as a traditional sexual
stimulant. Current research is only limited to
animal studies that have shown signicant
increases in erectile function after oral administration of the plant extract [19,20]. Several reports
demonstrated that, indeed, TT is able to increase
endogenous testosterone levels, which might be
the underlying mechanism for its erectileenhancing ability [1921]. However, exactly how
TT increases testosterone levels is still unclear.
Also, it is unknown if TT has nonandrogenic
effects that might contribute to its erectogenic
actions. Also, no clinical studies have been performed to date and recommendation for the usage
of TT in ED would be very premature.
Epimedii Herba (Horny Goat Weed)
Epimedii herba has been used as an energy and
erectile-enhancing drug in traditional Chinese
medicine for centuries. Icariin has been determined to be the main active component of Epimedii herba [22]. Animal studies reported signicant
increase in intracavernosal pressure following
administration of icariin [2325]. This was also
coupled to signicant increase in the expression
levels of inducible and neuronal nitric oxide synthases in the corpus cavernosum [25]. It is expected
41
that future clinical studies will delineate whether
or not Epimedii Herba is a successful natural
aphrodisiac.
42
controlled trials [36]. All in all the seven studies
evaluated 363 men aged from 24 to 70 years old.
The seven trials differed regarding the duration of
ED (130 years), etiology of ED (purely psychogenic in three studies, purely organic in 1 study
and mixed in the remaining three studies), duration of treatment (412 weeks), doses of ginseng
used (6001,000 mg, three times daily), and the
method of erectile function assessment (IIEF in
three studies, Watts sexual function questionnaire
in one study and the global efcacy question in
three studies) [3743]. The meta-analysis reached
the conclusion that ginseng improved sexual performance more than placebo. However, it should
be taken into account that some of these seven
studies did not report the nature of placebo used,
some did not report power calculation and some
did not describe baseline comparisons of ED
symptoms between the two arms (drug vs. placebo)
or obtain sufcient ethical approval. Thus,
drawing denitive conclusions of the aphrodisiac
effects of ginseng is very difcult [36]. Also, all
these studies focused completely on male sexual
dysfunction and ignored female sexual dysfunctions further undermining the ability to accurately
assess the aphrodisiac effects of red ginseng. The
mechanism of action of red ginseng is largely
unknown, with some animal studies reporting that
ginsenosides, the principle active constituents of
red ginseng, can lead to an increased release of
nitric oxide from the smooth muscles of the cavernous tissue, resulting in muscle relaxation
[37,38]. There is no known effective dose of red
ginseng, and side effects reported are usually mild
gastrointestinal upset [39,40].
Chocolate (Cacao)
Chocolate is made originally from the Cacao beans
after fermentation and multiple processing.
Chocolate often is considered the food with the
greatest impact on mood [44,45] and it has shown
a potential impact on overall human health
[46,47]. Chocolate contains a wide range of
chemical compounds that are pharmacologically
active such as methylxanthines and Narachidonoylethanolamine (a brain lipid that can
mimic the psychoactive effects of cannabinoids
[48]. Interestingly, several studies reported that
some chocolate constituents (especially serotonin
and avinoids) may be involved in modulating
womens genital sexual functioning [49,50]. Serotonin, which may act both as a vasoconstrictor and
vasodilator, has been located in several regions of
the female genital tract in both animals and
J Sex Med 2010;7:3949
Shamloul
humans. Recently, Salonia and colleagues tried
to examine the effects of chocolate on womens
sexual health [51]. Using several female sexual
function questionnaires they reported a positive
trend of higher scores (and therefore better sexual
function) in women consuming daily chocolate vs.
women who do not. However, when the data was
adjusted to age, this difference was lost. Finding an
association between chocolate and sexual health is
very tempting, however, further in-depth studies
should be conducted before a solid conclusion
could be reached [51].
43
Natural Aphrodisiacs
Table 1
Plant
Effects
*Type of studies
Mechanism of action
*Animal [69,70]
Unknown
*Animal [71]
Testosterone
*Animal [72,73]
Unknown
Rhizomes; India
*Animal [74,75]
?Testosterone
*Animal [76,77]
Mucuna pruriens
Seeds; India
*Animal [78]
*Animal [7986]
?eNOS
?Antioxidant
?Testosterone
?Brain dopamine
Unknown
**Animal [8793]
Camellia sinensis
Aframomum melegueta and
Piper guineense
Curculigo orchioides (Kali
Musli)
Microdesmis keayana
?Indirect LH secretion
Smooth muscle contraction
Many toxic effects
Female sexual function
*Males only; apart from th three studies on Tongkat Ali [8082], all other studies involved young animals (<20 weeks old).
**References [75,77] used female rats.
eNOS = endothelial nitric oxide synthase; LH=luteinizing hormone.
44
aphrodisiacs, however, this may be because of the
fact that their consumption lead to sweating,
burning, and distraction, physical responses very
similar to that a encountered during sexual intercourse [95]. Other popular aphrodisiacs include
oysters, shark components, rhinoceros horn and
snakes are largely used because of their physical
similarity to the genital organs. Several other hard
to nd substances are still used as aphrodisiacs, for
example, dried tigers penises soup, snake blood,
and even the melted fat of a camel hump and
leeches [1]. Although any substance may be
claimed as a good aphrodisiac, however, scientic
data is needed to prove these claims.
Discussion
Shamloul
Yohimbine, Ginseng and Maca are examples of
the very limited number of natural aphrodisiacs
that underwent rigorous scientic investigations
to explore their aphrodisiac properties. Data on
yohimbines efcacy does not support the wide use
of the drug; it has only mild effects in the treatment of psychogenic ED. Although there is a positive trend towards recommending red ginseng as
an effective aphrodisiac, however, more in depth
studies involving large number of subjects with
elucidation of its mechanism of action(s) are
needed before denite conclusions could be
reached. Macas aphrodisiac effects are through
the enhancement of whole body vitality with no
specic benet on sexual function. Recent scientic evidence regarding the use of alcohol as an
aphrodisiac is potentially interesting; however, the
existence of controversial data necessitates extensive future investigations. Current scientic body
of literature refutes the claims that cannabis and
marijuana have any aphrodisiac properties and
provides evidence to the exact contrary [98].
Despite the fact that many aphrodisiacs may be
used by men and women alike, (ginseng, maca,
tongkat ali) studies on the use of aphrodisiacs by
women or female animals are extremely rare
(Table 1). A reasonable explanation for this paucity
is that scientic interest in exploring female sexual
dysfunctions only began few decades ago [99101]
and more time may be needed to investigate
womens attitude towards aphrodisiacs. Also, this
may be because of the gender differences between
men and women regarding sexual behavior [99].
Obviously, there is a strong need to understand the
effects of different aphrodisiacs on women sexual
function.
A whole industry is built on manufacturing
natural aphrodisiacs. Although the precise size of
this industry is unknown, a quick visit to any drug
store and examination of the number of products
being marketed as natural aphrodisiacs will give an
idea on the huge amounts of money invested in
this industry. Unfortunately, some medicinal drug
manufacturers, realizing the huge demand towards
natural aphrodisiacs, go ahead and deceive the
public concerning the natural aphrodisiac products they market. In 2002, Mikami et al, reported
for the rst time the discovery of sildenal analogues in herbal aphrodisiacs [102]. Most
sildenal analogues found as adulterants have been
modied in the piperazine portion of the molecule
[103107]. However, recently, herbal dietary
supplements were found to contain sildenal analogues developed by replacing a carbonyl group in
45
Natural Aphrodisiacs
sildenal with a thiocarbonyl group, making their
detection more difcult [108110]. These sildenal analogues can inhibit PDE5 and/or PDE6 in
vitro, meaning the content of a capsule may cause
pharmacological effects [111]. In 2009, several
studies employed a new technique to detect the
newly-developed sildenal analogues, and reported the presence of sildenal analogues in at
least 10 herbal supplements marketed as natural
aphrodisiacs [111113]. Health authorities
should be aware of this problem and must take
necessary precautions to protect the public against
consumption of false natural aphrodisiacs.
In conclusion, the current body of objective evidence does not support the use of any natural
aphrodisiac as an effective treatment for male or
female sexual dysfunctions. Despite the recent
advances in the science of sexual medicine regarding the development of successful erectogenic
drugs and the current disappointing data on the
efcacy of natural aphrodisiacs, men with ED and
otherwise potent men will continue the unstoppable search for natural aphrodisiacs to increase
their sexual desire and performance. Sexual medicine specialists should keep their patients and the
public aware of the current evidence regarding the
use of natural aphrodisiacs and the hazards related
to their consumption.
Corresponding Author: Rany Shamloul, MD,
Queens University, Kingston, ON, Canada, K7L3N6.
Tel: 1-6135336432; Fax: 1-6135336412; E-mail:
ranyshamloul@gmail.com
Conict of interest: None.
Statement of Authorship
Category 1
(a) Conception and Design
Rany Shamloul
(b) Acquisition of Data
Rany Shamloul
(c) Analysis and Interpretation of Data
Rany Shamloul
Category 2
(a) Drafting the Article
Rany Shamloul
(b) Revising It for Intellectual Content
Rany Shamloul
Category 3
(a) Final Approval of the Completed Article
Rany Shamloul
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