1

pH

90

1 pH
2

3
4

P-450

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AUCext
AUCiv
AUCT
F=
AUCR
F=

D iv
100%
D ext
DR
100%
DT

L L/kg
Vd
Vd<5 L
3L<Vd<5L
10L<Vd<20L
Vd=40L
Vd<100L
,

5
6
7

50
ED50

LD50

LD50

1
2
3
4
5
6
7
8
9

1
2G

1 14

1
2
1

1
2
3
4
,

1LD50
ED50LD50/ED50
2
3
4

1
2
3
4

2
3
4
5
6

, -

PBPs

G
1
2
3

G
G

--
-
+
,

G G

1
2
3
4

1
2
3
4

2~10

2~4

1
2
3
4

DNA DNA

17.6

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PABA

l
2
3

1
2
3
4

SD

SIZ

B 10

AZT
FDA HIV
HIV DNA HIV

DNA

DNA

DNA

IFN

3 14

 70
3

1
B6
2
3

DNA RNA
mRNA RNA

4%
1
2
3

PAS
RNA

1
2

PAS-Na

PZA
PAS

2
1
2
3

1
2

DNA
RNA

5-FU

5-FU
5-FU

5-FU
MTX

MTX

6-MP

6-

DNA
CTX

RNA
D

ACh
ACh

N2 ACh

1
2
3
4

M
M N M N

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1
2
1
2
3
3

4
1
2
5

4
5
6

24~36
1%

1
Adr

1
2
3
4

DA

2
NANE

1
2

1
2

5 14

 NA

3
Iso

1 2 Iso

1
2
3
4

l
2

l
2
3
4
5

1
1
2
3
2

l
2
3
4

2
,
BZ

l
2
REM

3
4

BZ GABA

2
3

5~10

6~8

Na+ Ca2+ Na+ Ca2+

K+
GABA GABA
2
3

1
2
3

4
5

ADH

1%

1
2
3

l
2
3

B MAO-B

COMT

D3

D2

NMDA
AD

M
l
1
2
3

4
2
M

3
ACTH

1
2
3

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NA DA NH NA

5-HTNA

l
2 M
3
T

NA
NA
5-HT M

5-HT

5-HT
5-HT

MAO-A

1
1
2
3
4
2

CO2

1
2
3
4

2
7 14

80100

l/3 l/2

3~4

l/3 l/2

l/3

2
3

1
2 PG TXA2

1
2
3

45g/

PG

70

1
2
3
4 ERP

ABC
IA
IB
IC

IA

+
2+
+
Na Ca K

1
2
3
4

IB

+
+
Na K
1
2
3

IC

- APD/ERP
ERP

1
2
3

1
2
0.5~1.0g/

+
2+
+
Na Ca K

2
3

ACEI AT1

ACEI

1
Na+K+-ATP
Ca2+
2
3
1
2
3

B1

2
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l
2
3

1
2
3

4
1

60

2
34 1g

1
2

RAS

~
2
+
Na

cAMP , cAMP

l
2--
1
2
3
3
4
5
1
2
3
41
5
6
7
85-HT2
9

+
+
+
2+
Na Na Na -Ca
2+
Ca

9 14

--
1

--

10

1
1

2~4

I1-

- NA2

10

1 NA

l
ACEIAT1
2
3

ACEI

ACEI

1
2

NO

1
2

1~2

8h

1
TC LDL TG HDL

HMG-CoA LDL
TC LDL Ch VLDL

C
-

LDH

TG

TC LDL HDL TG

FH
TC TG

VLDL TG TC LDL
HDL

VLDL TG
A
HDL Ch
LDL
FH
TG

2
B
TG VLDL LDL HDL

TG
TG VLDL TG 45~65TG VLDL
LDL
FH

1
2 VLDLTG
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3 AS

+
+
Cl Na K 2Cl
+
+
Cl Na K Cl
2+
2+
Ca Mg

1
2
3
4
5

l
2
3

l NaCl
+
Na Cl NaCl
+
+
Na K HCO3
2
3

1
2
3

1
2
3

Na+ Na+
+
K

+
+
K -Na

1 2~4

20

l
2

1
2

1
AT-

11 14

1
2DIC
3

l
2

K
K

6-

TXA2
75~150mg/

cAMP

SK
UK
t-PA

FA

B12
B12

1 2
l
l~2 1

12

l/4

H2

H2

H+

H+

H2

PGE

5-HT3

3~4

l A2

2
B

MDF

6
7

l 2 3
4 5 6 7

1
1

2
3
4
5
6

2
1
2

1
2
3

1 2 3

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1
2

l
2
3

1 2 3

l
2

5- T3

1
1I
2

3
4
2GIK

l 2 3

l
2

PGI2

70~80

1
2

3
4

13 14

1
2

1 2

2
3

l 2 3
4

1
2. 3. 4 5
6

1 2 3 4 5
6 7 8 9

1
2
3
4

1
2 3

1
2 3 4
5

14

V cGMP

T-
B

BCG

T B
K NK
-2IL-2
T B NK

INF

NK

-H1

1 H1 H1

2 H1

1
2
3

5-