biperiden (Oral route)

bye-PER-i-den

Commonly used brand name(s):

In the U.S.

 Akineton

Available Dosage Forms:

 Tablet

Therapeutic Class: Antiparkinsonian

Pharmacologic Class: Anticholinergic

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Uses For biperiden

Biperiden is used alone or together with other medicines (e.g., levodopa) to treat Parkinson's
disease. By improving muscle control and reducing stiffness, biperiden allows more normal
movements of the body as the disease symptoms are reduced.

Biperiden is also used to control severe muscle reactions and other side effects from certain
medicines that are used to treat severe nausea or nervous, mental, or emotional conditions (e.g.,
chlorpromazine [Thorazine®], perphenazine [Trilafon®], prochlorperazine [Compazine®],
promethazine [Phenergan®], thioridazine [Mellaril®]).

biperiden is available only with your doctor's prescription.

Before Using biperiden

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good
it will do. This is a decision you and your doctor will make. For biperiden, the following should
be considered:

Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to biperiden or any other
medicines. Also tell your health care professional if you have any other types of allergies, such
as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or
package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of
biperiden in the pediatric population. Safety and efficacy have not been established.

Geriatric

No information is available on the relationship of age to the effects of biperiden in geriatric

patients. However, elderly men are more likely to have age-related prostate problems, which may
require caution for patients receiving biperiden.

Pregnancy

Read more: http://www.drugs.com/cons/biperiden.html#ixzz0nU7RssRV

Food Interactions: Take with food to reduce irritation.

Generic Name: Methotrimeprazine
Synonyms: Levomepromazine
Drug Category: Antipsychotic Agents; Dopamine Antagonists; Analgesics, Non-Narcotic
Drug Type: Small Molecule; Approved
Other Brand Names containing Methotrimeprazine: Nosinan; Nozinan; Levoprome; Neurocil; Neozine;
Absorption: Methotrimeprazine has an incomplete oral bioavailability, because it undergoes
considerable first-pass-metabolism in the liver. Oral bioavailability is approximately 50 to 60%.
Toxicity (Overdose): Symptoms of overdose include convulsions, spastic movements, and coma.
Protein Binding: Not Available
Biotransformation: Hepatic. Methotrimeprazine is metabolized in the liver and degraded to a sulfoxid-,
a glucuronid- and a demethyl-moiety.
Half Life: Approximately 20 hours.
Dosage Forms of Nozinan: Tablet Oral
Solution Intramuscular

Additional information about Loxitane Im

Loxitane Im Indication: For the management of the manifestations of psychotic disorders

Mechanism Of Action: Loxitane Im is a dopamine antagonist, and also a serotonin 5-HT2
blocker. The exact mode of action of Loxitane Im has not been established, however changes in
the level of excitability of subcortical inhibitory areas have been observed in several animal
species in association with such manifestations of tranquilization as calming effects and
suppression of aggressive behavior.
Drug Interactions: Donepezil Possible antagonism of action
Galantamine Possible antagonism of action
Rivastigmine Possible antagonism of action
Food Interactions: Take with food to reduce irritation. Avoid alcohol.
Generic Name: Loxapine
Synonyms: Not Available
Drug Category: Antipsychotics; Dopamine Antagonists
Drug Type: Small Molecule; Approved
Other Brand Names containing Loxapine: Cloxazepine; Dibenzacepin; Dibenzoazepine;
Hydrofluoride 3170; Lossapina [Dcit]; Loxapac; Loxapin; Loxapina [Inn-Spanish]; Loxapine
[Usan:Ban:Inn]; Loxapinum [Inn-Latin]; Loxepine; Loxitane C; Loxitane Im; Oxilapine;
Absorption: Systemic bioavailability of the parent drug was only about one third that after an
equivalent intramuscular dose (25 mg base) in male volunteers
Toxicity (Overdose): LD50=65 mg/kg (Orally in mice)
Protein Binding: Not Available
Biotransformation: Hepatic
Half Life: Oral-4 hours
Dosage Forms of Loxitane Im: Tablet Oral
Solution Oral
Liquid Intramuscular