Leptotene Meiosis I begins with the condensation of the chromosomes.
Zygotene Homologous chromosomes synapse and pair along their entire length, forming bivalents. The homologous chromosome pair is a four-stranded complex called tetrad. Pachytene Sister chromatids are visible as two long threads. Crossing over occurs but chiasmata are not yet visible. Diplotene Pairs of homolog chromosomes begin to separate at/around centromere; chromatids twist and chiasmata (crossover points) become visible. Diakinesis bivalents are shortened and thickened (tightedly coiled and compacted). *Crossing-over (or crossover) requires the chromosomes break and reconnect to the other chromosome. **Crossing-over, together with independent assortment of non-homologous chromosomes (which creates different combinations of alleles among chromosomes), contribute to genetic variation among individuals.