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Fear of Childbirth and Pregnancy Related Anxiety 13 PDF
Fear of Childbirth and Pregnancy Related Anxiety 13 PDF
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PhD,
Collection of the data has been reported previously.17 In short, the participants completed a set of
questionnaires at a mean of 20 (standard deviation
[SD] 3.2) weeks of gestation. In addition, the
recruiting infertility doctor or the research nurse
collected information on preceding infertility treatments from clinics patient registries and on the
medical and obstetric histories of the participants by
means of structured questions.
Fear of childbirth was assessed by means of the
revised version of the Fear-of-Childbirth Questionnaire (Cronbachs alpha 0.72). The original Questionnaire18 was revised to suit a Finnish population by
Saisto.8,19 The revised Fear-of-Childbirth Questionnaire consisted of 11 dichotomous questions, and
affirmative answers indicated fear. Pregnancy-related
anxiety was assessed by means of the Pregnancy
Anxiety Scale (Cronbachs alpha 0.80) revised by
Levin.20 This has shown high reliability, including in
Finnish samples.8,19 The anxiety scale covered three
dimensions of pregnancy-related anxiety: anxiety
about being pregnant, anxiety about giving birth, and
anxiety about hospitalization. It included 10 five-scale
questions (one not at all, five a lot). Total scores
equal to or higher than the 90th percentile in the
revised Fear-of-Childbirth Questionnaire (total scores
6 or higher) and Pregnancy Anxiety Scale (total scores
30 or higher) were considered to show severe fear
and severe pregnancy-related anxiety, respectively.8 With 80% power, .05 two-sided significance, we
could detect a difference of 7% in the prevalence of
severe fear of childbirth and pregnancy-related anxiety between the ART and control groups. Total scores
in the revised Fear-of-Childbirth Questionnaire and
Pregnancy Anxiety Scale were highly correlated (r
0.73, P .001).
The participants were also asked to report the
presence or absence of somatic symptoms (none,
hyperemesis, bleeding, other not specified) in structured dichotomous questions.
The statistical software package SPSS 12.0.1
(SPSS Inc., Chicago, IL) was used for all data analyses. Continuous variables were analyzed by means of
Student t test. Categorical variables were analyzed by
means of Fisher exact test. A P value less than .05 was
regarded as statistically significant. Two separate adjusted multiple logistic regression analyses were run
regarding the nulliparous participants. First, the impact of demographic factors such as age (20 29,
30 34, 35 44 years), educational level (high professional, low professional, skilled worker, unskilled
worker), type (married or cohabiting) and duration of
partnership (less than 5, 510, more than 10 years),
Poikkeus et al
71
RESULTS
Three hundred sixty-seven (92.4%) out of 397 initially
recruited women conceiving after ART and 379
(81.7%) out of 464 control women took part in the
study (P .001). The studied pregnancies represent
367 of 412 (89.1%, ART group) and 379 of 2,187
(17%, control group) of eligible pregnancies from the
recruiting clinics in 1999.
The demographic data, obstetric history, and
somatic symptoms are presented first among all participants and then among nulliparous women in Table
Total (n)
Age [y, mean (SD)]
Education [n (%)]
High professional
Low professional
Skilled worker
Unskilled worker
Married [n (%)]
Cohabiting [n (%)]
Duration of partnership [y, mean (SD)]
Previous Pregnancies [n (%)]
Miscarriages
Legal abortions
Ectopic pregnancies
Previous Live births [n (%)]
Previous Delivery [n (% of previous births)]
Vaginal, spontaneous
Operative
Data Missing
Somatic symptom in present pregnancy
None
Hyperemesis
Bleeding
Other not specified
Nulliparous
ART
Control
P*
ART
Control
367
33.0 (4.2)
379
33.3 (3.0)
.18
260
32.1 (4.1)
135
32.8 (3.0)
.05
100 (27.2)
150 (40.9)
58 (15.8)
47 (12.8)
254 (69.2)
81 (22.1)
9.7 (4.4)
182 (49.9)
69 (18.8)
36 (9.8)
31 (8.4)
107 (29.2)
126 (33.2)
165 (43.5)
47 (12.4)
39 (10.3)
243 (64.1)
123 (32.5)
7.7 (4.4)
274 (72.3)
75 (19.8)
34 (9.0)
4 (1.1)
244 (64.4)
.13
.71
.14
.25
.005
.008
.001
.001
.78
.71
.001
.001
67 (25.8)
109 (41.9)
45 (17.3)
32 (12.3)
178 (68.5)
64 (24.6)
8.8 (4)
81 (31.2)
51 (19.6)
21 (8.1)
19 (7.3)
0
50 (37.0)
57 (42.2)
17 (12.6)
11 (8.1)
71 (52.6)
58 (43.0)
6.2 (3.9)
36 (26.7)
25 (18.5)
10 (7.4)
2 (1.5)
0
.04
.91
.19
.23
.001
.001
.001
.27
.89
.85
.02
51 (47.7)
15 (14.0)
41 (38.3)
88 (36.1)
37 (15.1)
119 (48.8)
286 (77.9)
29 (7.9)
35 (9.5)
17 (4.6)
293 (77.3)
22 (5.8)
29 (7.7)
35 (9.3)
.86
.31
.86
.05
202 (77.7)
18 (6.9)
27 (10.4)
13 (5.0)
110 (81.5)
4 (3.0)
7 (5.2)
13 (9.6)
.44
.16
.09
.09
72
Poikkeus et al
Nulliparous
Total
107
Etiology of infertility
Female
36 (33.6)
Male
30 (28.0)
Combined
23 (21.5)
Unexplained
18 (16.8)
Duration of infertility [y, mean (SD)] 6.3 (2.9)
Studied treatment cycle
IVF
32 (29.9)
ICSI
21 (19.6)
FET
54 (50.5)
260
86 (33.1)
65 (25.0)
48 (18.5)
61 (23.5)
4.1 (2.3)
114 (43.8)
49 (18.8)
97 (37.3)
367
42 (11.4)
46 (12.5)
260
34 (13.1)
37 (14.2)
107
8 (7.5)
9 (8.4)
Control
379
40 (10.6)
38 (10.0)
135
19 (14.1)
20 (14.8)
244
21 (8.6)
18 (7.4)
P
.56
.16
1.00
1.00
1.00
.51
ART, assisted reproductive technology; rFDQ, revised Fear-ofChildbirth Questionnaire; PAS, Pregnancy Anxiety Scale.
* Total scores equal to or more than the 90th percentile in revised
Fear-of-Childbirth Questionnaire or in Pregnancy Anxiety
Scale.
DISCUSSION
The number of annual ART cycles is increasing in
Europe and the United States, and understanding both
the psychological and somatic consequences of these
treatments is needed.2122 We hypothesized that cumulative stress and previous disappointments after infertility investigations and treatments could promote fear of
childbirth and pregnancy-related anxiety in women
conceiving after ART. However, according to our results, infertility and ART do not expose a woman to an
increased risk of fear of childbirth, supporting the results
of earlier case-control studies.8 10 Only women with a
long period of infertility appear to be a vulnerable group
in terms of severe fear of childbirth. Our results further
show that women conceiving after ART are not more
anxious about the pregnancy than the controls, in
contrast to previous results.15,16 Interestingly, nulliparity
was associated with more prevalent severe pregnancyrelated anxiety in the control group, but not in the ART
group. More frequent fear of childbirth among nulliparous women has been reported previously.2326
We analyzed fear of childbirth and pregnancyrelated anxiety at previously used assessment time
and by means of reliable and valid methods.8,19
Nearly 90% of eligible pregnant ART women took
part in this study, and in terms of age and parity our
ART group is representative compared with both
national and international ART registers.27,28 The
Poikkeus et al
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Table 4. Multiple Logistic Regression Analysis: Prediction of Severe Fear of Childbirth and Severe
Pregnancy-Related Anxiety* in Nulliparous Participants
Severe Fear of Childbirth in rFDQ
(Total Scores 6 or Higher)
Age (y)
2029
3034
3544
Educational level
High professional
Low professional
Skilled worker
Unskilled worker
Married
Yes
No
Duration of partnership (y)
Less than 5
510
More than 10
Previous nonviable pregnancy
None
One or more
Somatic symptom
None
Any
Severe Pregnancy-Related
Anxiety in PAS
(Total Scores 30 or Higher)
OR
95% CI
OR
95 % CI
62
202
90
1
1.2
0.7
0.53.0
0.22.0
62
204
92
1
0.8
0.8
0.31.8
0.32.0
107
151
56
40
1
1.6
1.8
1.6
0.73.4
0.74.9
0.55.1
107
154
56
41
1
1.3
1.5
0.7
0.62.5
0.63.7
0.22.2
238
116
1
0.6
0.31.2
240
118
1
0.8
0.41.7
111
150
93
1
0.3
0.5
0.20.7
0.21.1
112
152
94
1
0.6
0.9
0.31.3
0.42.0
248
106
1
1.6
0.83.0
251
107
1
1.5
0.82.7
278
76
1
0.7
0.31.7
281
77
1
0.8
0.41.7
rFDQ, revised Fear-of-Childbirth Questionnaire; PAS, Pregnancy Anxiety Scale; OR, odds ratio; 95% CI, 95% confidence interval.
* Total scores equal to or more than the 90th percentile in revised Fear-of-Childbirth Questionnaire or in Pregnancy Anxiety Scale.
Reference group.
medians of total revised Fear-of-Childbirth Questionnaire and Pregnancy Anxiety Scale scores were relatively low and comparable with those among unselected Finnish pregnant women.8 Comparison of our
scores with results from international studies is unfortunately not possible because the content of fear-ofchildbirth questionnaires, and the assessment time,
vary from one study to another. Our assessment of
fear of childbirth and pregnancy-related anxiety at the
second trimester is clinically reasonable because it
leaves enough time for therapeutic interventions before delivery. However, our results from the 20th
gestational week may be influenced by more pronounced general well-being than results from the
other trimesters.29 33
A couple of limitations of our study deserve
mention. First, our sample size was not sufficient to
detect the relatively small differences in prevalence of
severe fear of childbirth and pregnancy-related anxiety as noticed in this material with high power.
Indeed our studys power to detect the observed
differences in prevalence of severe fear of childbirth
and severe pregnancy-related anxiety was 4% and
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Poikkeus et al
Table 5. Multiple Logistic Regression Analysis: Prediction of Severe Fear of Childbirth and Severe
Pregnancy-Related Anxiety in Nulliparous Assisted Reproductive Technology Participants
Severe Pregnancy-Related
Anxiety in PAS
(Total Scores 30 or Higher)
Etiology of infertility
Female*
Male
Combined
Unexplained
Duration of infertility (y)
03*
46
7 or more
Number of treatment
1st*
2nd
3rd
4th
More than 4th
Treatment type
IVF*
ICSI
FET
OR
95% CI
OR
95% CI
72
59
41
64
1.0
0.9
0.3
0.6
0.32.6
0.071.5
0.21.6
72
59
41
65
1.0
0.7
0.4
0.4
0.22.3
0.091.7
0.11.3
130
78
28
1.0
1.3
4.4
130
79
28
1.0
1.3
3.0
87
50
38
21
40
1.0
0.3
0.8
0.3
0.06
0.061.4
0.23.1
0.041.8
0.0050.7
86
51
38
21
41
1.0
0.6
0.6
0.4
0.1
103
45
88
1.0
0.9
0.9
0.23.3
0.23.5
102
45
90
1.0
3.0
3.6
0.53.5
1.216.9
0.43.7
0.712.4
0.13.0
0.13.1
0.052.9
0.021.3
0.613.2
0.816.0
rFDQ, revised Fear-of-Childbirth Questionnaire; PAS, Pregnancy Anxiety Scale; OR, odds ratio; 95% CI, 95% confidence interval; IVF,
in vitro fertilization; ICSI, intracytoplasmic sperm injection; FET, frozen embryo transfer.
* Reference group.
Poikkeus et al
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Poikkeus et al