Genetic it's also a fact at the time of talking about cerebrovascular diseases not

affecting directly but caring other facts that can be heredity as the hypertension ,
subarachnoid hemorrhage , atria fibrillation diseases which were have already
talked about but are some other genetic facts that affects cerebrovascular diseases
that can only go over generation to generation like the congenital deficiency of
protein C or S which is a deficit of these proteins in the blood plasma that helps to
reduce the formation of clots in the blood producing brain stroke and as it is
congenital you born with it rising the probability to suffer cerebrovascular accidents
at early ages , also a genetic disease that help cerebrovascular accidents is the
cerebral amyloidal angiopathy which consist in the accumulation of amyloidal
protein in the veins of the brain rising the probability of suffering hemorrhagic
cerebrovascular accidents by weakening brain vessels that can break with the
blood pressure or any other fact that affects the blood fluid it also raise the risk of
suffering insanity , there is another genetic disease called cerebral autosomal
dominant arteriopathy with subcortical infarcts and leukoencephalopathy or
CADASIL in acronym which is a disease caused by the mutation of gene NORTH3
located in the 19 chromosome that mainly affect subcortical structures as lacunars
lesions, white matter lesions , heavy bleeding or microbleedings , the symptoms
can be various cerebrovascular ischemic accidents , migraine , mood alteration
and dementia in some cases it can cause intracerebral hemorrhages also some
studies show that this disease decreases neurovascular coupling damaging
functions of the brain . Also cavernomas are hereditary too which are bad
formations of the vessels that looks like a raspberries , "family forms are
transmitted by autosomal dominant inheritance and therefore, children have 50%

risk of developing the disease" (R.Palencia, 2004) which show the high risk
children's have of contracting this bad formation of brain vessels making them
more prone to cerebrovascular accidents since the day they are born and effects
that these disease will have in their lives are that "10-25% present intracranial
hemorrhage and bleeding risk in the clinical course is estimated at 0.2-2% per
patient and year" (R.Palencia, 2004) which show the tendency this patients have of
suffering cerebrovascular accidents cause this bad formations of the vessels or
more prone to break cause victim of the pressure of the blood .
Factor V leiden it's also a genetic mutation which affects the resistance of C protein
which as it's mentioned before have a roll in the coagulation system " the
coagulation process starts with the activation of the thrombomodulin by thrombin
on the inner surface of the endothelial cell . After the thrombomodulin is combined
with the C protein and activated protein C or aPC is produced . This aPC joints to
the S protein on the platelet surface and degrades factor V leiden. These last two
steps promotes thrombolysis as part of the normal blood homeostasis. Having this
mutation will produce in the patient an inactivation of the factor V leiden 10 times
slower than those with normal factor V leiden as a result factor V leiden stay more
time in the body and as a result it will raise the thrombin and a moderate
hypercoagulable state and other assets markers of coagulation " (Whizar-Lugo &
Hurtado Monrroy, 2008) ass it said it affects coagulation system by the formation of
clots at vessels and enabling the well capacity of the body to solve them producing
brain stroke by the block of the brain vessels . This particular gene mutation is hard
to detect because it is an asymptomatic disease making the investigation of the

familiar clinic history or lab exams that research specifically the formation of these
disease as the aPC resistance test and the DNA analysis F5 the only ways to
detect it .