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  • 2.1 Penelitian Yang Berhubungan Dengan Lipocalin-Type Prostaglandin D2 Synthase Tabel 2. Penelitian Yang Berhubungan Dengan L-PGDS

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    This table summarizes 8 studies related to Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS): 1. Several studies found that L-PGDS levels in urine and tissue can detect early kidney injury, with urine L-PGDS being a good marker for renal injury with 67% sensitivity and 86% specificity. 2. L-PGDS levels were also found to increase in patients with hypertension and correlated with blood pressure and kidney damage. 3. One study also found that L-PGDS levels are related to neuroinflammatory diseases. 4. The studies used methods like ELISA, IHC, and sandwich assays to examine biomarkers like L-PGDS

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    This table summarizes 8 studies related to Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS): 1. Several studies found that L-PGDS levels in urine and tissue can detect early kidney injury, with urine L-PGDS being a good marker for renal injury with 67% sensitivity and 86% specificity. 2. L-PGDS levels were also found to increase in patients with hypertension and correlated with blood pressure and kidney damage. 3. One study also found that L-PGDS levels are related to neuroinflammatory diseases. 4. The studies used methods like ELISA, IHC, and sandwich assays to examine biomarkers like L-PGDS

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    2.1 Penelitian Yang Berhubungan Dengan Lipocalin-Type Prostaglandin D2 Synthase Tabel 2. Penelitian Yang Berhubungan Dengan L-PGDS

    Uploaded by

    budi F
    This table summarizes 8 studies related to Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS): 1. Several studies found that L-PGDS levels in urine and tissue can detect early kidney injury, with urine L-PGDS being a good marker for renal injury with 67% sensitivity and 86% specificity. 2. L-PGDS levels were also found to increase in patients with hypertension and correlated with blood pressure and kidney damage. 3. One study also found that L-PGDS levels are related to neuroinflammatory diseases. 4. The studies used methods like ELISA, IHC, and sandwich assays to examine biomarkers like L-PGDS

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    of 1

    2.

    1 Penelitian yang Berhubungan dengan Lipocalin-Type Prostaglandin D2 Synthase


    Tabel 2. Penelitian yang berhubungan dengan L-PGDS
    No

    Peneliti

    Tahun

    1.

    Ogawa dkk.

    2006

    Uehara dkk.

    2008

    2.

    3.

    Hamano dkk

    2002

    4.

    Hirawa dkk

    2001

    Populasi
    Renal tumor
    (n=82) vs. non
    renal tumor
    Berbagai Renal
    disease (n=200)
    vs. populasi sehat
    (n=793)
    CKD tissue
    (n=102) and urine
    (n=57)
    Diabetes (N=36)
    vs normal (n=29)

    5
    Yoshikawa
    dkk.

    2007

    Hirawa dkk.

    2002

    Lee dkk

    2009

    Hipertensi
    (n=111) vs
    normotensi
    (n=102)

    Rancangan
    Penelitian
    Retrospektif &
    prospectif

    Biomarker lainnya

    Biomarker
    yang diperiksa

    Metoda
    pemeriksaan

    RCC-Ma

    Jaringan dan
    urin KIM-1

    IHC, ELISA

    Urin albumin,
    uIVC,ub2M,uNAG,
    sCr

    Retrospektif

    No

    Jaringan dan
    urine KIM-1

    IHC, ELISA

    Cross-sectional
    & prospective

    sCr

    Urin dan
    plasma LPGDS

    ELISA

    Urine KIM-1 correlated vs tissue


    KIM-1, negative correlation with
    renal function; no correlation
    Kadar L-PGDS mendeteksi lebih
    dini nefropati diabetik

    Cross-sectional
    dan Case
    control

    NAG, MMP-9

    Urin- KIM-1

    Sandwich,
    ELISA

    KIM-1 sebagai deteksi dini pada


    pasca operasi CKD sebelum
    peningkatan Scr

    Urine-serum LPGDS

    Sandwich
    ELISA

    LCS L-PGDS

    Sandwich,
    ELISA

    Albuminuria, serum
    kreatinin

    Urin L-PGDS

    7
    8

    Tissue KIM-1 in clear


    RCC vs non-RCC. Marked
    decrease/disappearance in RCC
    post-nephrectom
    L-PGDS urin marker terbaik
    untuk renal injuri. Sensitivitas
    67% spesifitas 86 %

    Cross-sectional
    & prospective

    Retrospektif

    ELISA

    Hasil Penelitian

    Prospective

    Serum-urin LPGDS meningkat


    pd pop hipertensi. Metab L-PGDS
    berhub dgn tekanan darah dan
    kerusakan ginjal
    L-PGDS berhub dengan penyakit
    neuroinflamasi

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