Crecimiento y Metabolismo

07/10/2014
POWERPOINT LECTURE SLIDE PRESENTATION

by LYNN CIALDELLA, MA, MBA, The University of Texas at Austin
UNIT 4
4b
Control Endocrino
del Crecimiento y
Metabolismo
HUMAN PHYSIOLOGY
AN INTEGRATED APPROACH
FOURTH EDITION
DEE UNGLAUB SILVERTHORN

Copyright 2007 Pearson Education, Inc., publishing as Benjamin Cummings
Crecimiento Normal: Tiroides

Importancia relativa de las hormonas tiroideas, de la hormona del crecimiento y de
los andrgenos y estrgenos en varias fases de crecimiento.
07/10/2014
Glndula Tiroides: Estructura
Figure 23-7a
Glndula Tiroides: Estructura
Figure 23-7b
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Glndula Tiroides: Hormonas

Las hormonas tiroideas combinan I+tirosina
Figure 23-8
Tiroides:
Hormonas
Figure 23-8
07/10/2014

La sntesis de hormonas tiroideas sucede en el coloide
del folculo tiroideo
Blood
Na+
2
1
T3 T4 6
Follicular cell synthesizes enzymes

and thyroglobulin for colloid.
is co-transported into the cell with

Na+ and transported into colloid.
T3 T4
-
Protein
synthesis
5
Enzymes,
Thyroglobulin
Enzymes
T3 T4
Enzymes add iodine to thyroglobulin

to make T3 and T4.
Thyroglobulin is taken back into

the cell.
Intracellular enzymes separate T 3

and T4 from the protein.
Free T3 and T4 enter the circulation.
4
Follicular
cells
Thyroglobulin + 3
Colloid
Figure 23-9
Copyright 2007 Pearson Education,

T3 T4 T4Inc., publishing as Benjamin Cummings

Blood

1
Protein
synthesis
Enzymes,
Thyroglobulin
Follicular
cells
Thyroglobulin
Colloid
Figure 23-9, step 1
07/10/2014

Blood
Na+
2
1


Protein
synthesis
Enzymes,
Thyroglobulin
Follicular
cells
Thyroglobulin
+ -
Colloid
Figure 23-9, steps 12

Blood
Na+
2
1



to make T3 and T4.
Protein
synthesis
Enzymes,
Thyroglobulin
Follicular
cells
Thyroglobulin
+ -
3
Colloid
T3 T4 T4 Inc., publishing as Benjamin Cummings

07/10/2014

Blood
Na+
2
1



to make T3 and T4.

the cell.
Protein
synthesis
Enzymes,
Thyroglobulin
T3 T4
4
Follicular
cells
+ -
Thyroglobulin
3
Colloid


Blood
Na+
2
1



to make T3 and T4.

the cell.

T3 T4
-
Protein
synthesis
5
Enzymes
Enzymes,
Thyroglobulin
T3 T4
4
Follicular
cells
Thyroglobulin
+ -
3
Colloid

07/10/2014

Blood
Na+
2
1
T3
T4



to make T3 and T4.

the cell.

Free T3 and T4 enter the circulation.
T3 T4
-
Protein
synthesis
5
Enzymes
Enzymes,
Thyroglobulin
T3 T4
4
Follicular
cells
Thyroglobulin
+ -
3
Colloid


Formacin de T3 y T4
Figure 23-10
07/10/2014
Formacin de T3 y T4
Figure 23-10
Resumen
Figure 23-10
07/10/2014
Glndula Tiroides:
Hormonas
Control de la secrecin
tiroidea
Figure 23-12
07/10/2014
Control de la secrecin tiroidea
Figure 23-12
Hipertiroidismo
Aumenta el consumo de oxgeno y la produccin de
calor metablico
Incrementa el catabolismo proteico y causa debilidad
muscular
Reflejos hiperexcitables y alteraciones psicolgicas
Influencia receptores -adrenrgicos en el corazn:
taquicardia
10
07/10/2014
Hipertiroidismo: enfermedad de Graves
Hipertiroidismo:
enfermedad de Graves
11
07/10/2014
Hipotiroidismo
Reduce la tasa metablica y el consumo de oxgeno
Reduce la sntesis proteica
Reflejos lentos, enlentecimiento del habla y
pensamiento, fatiga
Cretinismo en nios
Bradicardia
Hipotiroidismo
12
07/10/2014
Hiper e Hipotiroidismo
Hiper e Hipotiroidismo
13
07/10/2014
Cretinismo
Resumen: acciones hormonales sobre la placa

epifisaria
14
07/10/2014

Bocio por excesiva estimulacin de TSH: deficiencia de I
Figure 23-13
El bocio puede suceder

en hiper o hipotiroidismo
Figure 23-14a
15
07/10/2014
Deficiencia de I-
Figure 23-14a
Figure 23-14b
16
07/10/2014

Exoftalmos, causado por hipertrofia de tejidos dentro de
la rbita, is un signo de Graves
Figure 23-15
Figure 23-15
17
07/10/2014
Crecimiento Normal: GH
Importancia relativa de las hormonas tiroideas, de la hormona del crecimiento y de
los andrgenos y estrgenos en varias fases de crecimiento.
Control de la Growth Hormone
Figure 23-16
18
07/10/2014
Control de la GH
Figure 23-16
Control de la GH
Figure 23-16
19
07/10/2014
Growth Hormone
Growth Hormone: efectos fisiolgicos
20
07/10/2014
Growth Hormone: efectos fisiolgicos
Growth Hormone
Esquema de la actividad de la
hormona del crecimiento (GH) y del
factor de crecimiento similar a la
insulina I (IGF-I) sobre el cartlago
de crecimiento. La GH estimula la
multiplicacin de los
precondroblastos, que expresan el
receptor para IGF-I, producido
tambin por las clulas diferenciadas
precondroblsticas, y facilita la
maduracin y multiplicacin celular.
La GH estimula la formacin de la
protena transportadora del IGF-I,
que forma un complejo con la
subunidad ALS; el complejo de 150
kDa escindido se desacopla y deja
IGF-I libre, que puede actuar sobre
las clulas objetivo.
21
07/10/2014
Growth Hormone
La deficiencia severa produce enanismo hipofisario
La hipersecrecin de GH en nios produce
gigantismo hipofisario
La hipersecrecin de GH en adultos produce
acromegalia
Growth Hormone
22
07/10/2014
Growth Hormone
Growth Hormone
23
07/10/2014
Acromegalia
Figure 23-17
Acromegalia
Figure 23-17
24
07/10/2014
Resumen: acciones hormonales sobre la placa

epifisaria
25

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07/10/2014

POWERPOINT LECTURE SLIDE PRESENTATION

DEE UNGLAUB SILVERTHORN

Crecimiento Normal: Tiroides

Copyright 2007 Pearson Education, Inc., publishing as Benjamin Cummings

Glndula Tiroides: Estructura

Copyright 2007 Pearson Education, Inc., publishing as Benjamin Cummings

Glndula Tiroides: Estructura

Copyright 2007 Pearson Education, Inc., publishing as Benjamin Cummings

Glndula Tiroides: Hormonas

Copyright 2007 Pearson Education, Inc., publishing as Benjamin Cummings

Copyright 2007 Pearson Education, Inc., publishing as Benjamin Cummings

Glndula Tiroides: Hormonas

Follicular cell synthesizes enzymes

is co-transported into the cell with

Enzymes add iodine to thyroglobulin

Thyroglobulin is taken back into

Intracellular enzymes separate T 3

Free T3 and T4 enter the circulation.

Copyright 2007 Pearson Education,

Glndula Tiroides: Hormonas

Follicular cell synthesizes enzymes

Figure 23-9, step 1

Glndula Tiroides: Hormonas

Follicular cell synthesizes enzymes

is co-transported into the cell with

Figure 23-9, steps 12

Copyright 2007 Pearson Education, Inc., publishing as Benjamin Cummings

Glndula Tiroides: Hormonas

Follicular cell synthesizes enzymes

is co-transported into the cell with

Enzymes add iodine to thyroglobulin

T3 T4 T4 Inc., publishing as Benjamin Cummings

Figure 23-9, steps 13

Glndula Tiroides: Hormonas

Follicular cell synthesizes enzymes

is co-transported into the cell with

Enzymes add iodine to thyroglobulin

Thyroglobulin is taken back into

T3 T4 T4 Inc., publishing as Benjamin Cummings

Figure 23-9, steps 14

Glndula Tiroides: Hormonas

Follicular cell synthesizes enzymes

is co-transported into the cell with

Enzymes add iodine to thyroglobulin

Thyroglobulin is taken back into

Intracellular enzymes separate T 3

T3 T4 T4 Inc., publishing as Benjamin Cummings

Figure 23-9, steps 15

Glndula Tiroides: Hormonas

Follicular cell synthesizes enzymes

is co-transported into the cell with

Enzymes add iodine to thyroglobulin

Thyroglobulin is taken back into

Intracellular enzymes separate T 3

Free T3 and T4 enter the circulation.

T3 T4 T4 Inc., publishing as Benjamin Cummings

Figure 23-9, steps 16

Glndula Tiroides: Hormonas

Copyright 2007 Pearson Education, Inc., publishing as Benjamin Cummings

Copyright 2007 Pearson Education, Inc., publishing as Benjamin Cummings

Copyright 2007 Pearson Education, Inc., publishing as Benjamin Cummings

Copyright 2007 Pearson Education, Inc., publishing as Benjamin Cummings

Copyright 2007 Pearson Education, Inc., publishing as Benjamin Cummings