Exercise 3: Neurophysiology of Nerve Impulses: Activity 4: The Action Potential: Importance of Voltage-Gated Na+

channels Lab Report

Pre-lab Quiz Results
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Experiment Results
Predict Question:
Predict Question 1: If you apply TTX between recording electrodes R1 and R2, what effect will the TTX have on the action
potentials at R1 and R2?
Your answer : a. TTX will have no effect at either location.
Predict Question 2: If you apply lidocaine between recording electrodes R1 and R2, what effect will the lidocaine have on
the action potentials at R1 and R2?
Your answer : a. Lidocaine will have no effect at either location.
Stop & Think Questions:
2. Enter the peak value of the response at R1 and R2 in the field below and then click Submit to record your answer in the
lab report.
You answered: 100 V
With a slower timescale, the appearance of the action potentials generated at R1 and R2 will appear to
You correctly answered: c. be compressed in time but have the same peak value of response.
Why do you think TTX is not used during dental procedures?
You correctly answered: c. TTX irreversibly blocks voltage-gated sodium channels in axonal membranes.
Experiment Data:
Condition

Stimulus
Voltage (mV)

Electrode

Control
Control
TTX
TTX
Lidocaine
Lidocaine

30
30
30
30
30
30

R1
R2
R1
R2
R1
R2

Peak Value
of Response
(V) 2 sec
100
100
100
100
100
100

Peak Value
of Response
(V) 4 sec
100
100
100
100
100
100

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Peak Value
of Response
(V) 6 sec
100
100
100
0
100
100

Peak Value
of Response
(V) 8 sec
100
100
100
0
100
0

Peak Value
of Response
(V) 10 sec
100
100
100
0
100
0

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Post-lab Quiz Results

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Review Sheet Results

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