30/8/2016

MultiDrugInteractionChecker

9InteractionsFound
PatientRegimen
calcitriol
carvedilol
cilostazol
nifedipine
nitroglycerintopical
omeprazole
rosuvastatin
aspirin

acetylsalicylicacid
methotrexate

SeriousUseAlternative
aspirin+methotrexate
aspirinincreaseslevelsofmethotrexatebydecreasingrenalclearance.AvoidorUseAlternateDrug.Caution
shouldbeexercisedwhensalicylatesaregivenincombinationwithmethotrexate.Riskfordruginteractions
withmethotrexateisgreatestduringhighdosemethotrexatetherapy,ithasbeenrecommendedthatanyof
thesedrugsbeusedcautiouslywithmethotrexateevenwhenmethotrexateisusedinlowdoses.

omeprazole+cilostazol
omeprazolewillincreasetheleveloreffectofcilostazolbyaffectinghepaticenzymeCYP2C19metabolism.
AvoidorUseAlternateDrug.

SignificantMonitorClosely
nifedipine+cilostazol
nifedipinewillincreasetheleveloreffectofcilostazolbyaffectinghepatic/intestinalenzymeCYP3A4
metabolism.UseCaution/Monitor.

omeprazole+methotrexate
omeprazoleincreaseslevelsofmethotrexatebydecreasingrenalclearance.UseCaution/Monitor.Temporary
withdrawalofPPImaybeconsideredinsomepatients.

aspirin+carvedilol
aspirindecreaseseffectsofcarvedilolbypharmacodynamicantagonism.UseCaution/Monitor.Longterm(>1
wk)NSAIDuse.NSAIDsdecreaseprostaglandinsynthesis.

aspirin+cilostazol
aspirin,cilostazol.Eitherincreasestoxicityoftheotherbypharmacodynamicsynergism.Use
Caution/Monitor.Theneedforsimultaneoususeoflowdoseaspirinandanticoagulantorantiplateletagents
arecommonforpatientswithcardiovasculardiseasemonitorclosely.

carvedilol+nifedipine
carvedilolandnifedipinebothincreaseantihypertensivechannelblocking.ModifyTherapy/MonitorClosely.

carvedilol+aspirin
carvedilolandaspirinbothincreaseserumpotassium.UseCaution/Monitor.

Minor
omeprazole+carvedilol
omeprazolewillincreasetheleveloreffectofcarvedilolbyaffectinghepaticenzymeCYP2C9/10
metabolism.Minor/SignificanceUnknown.

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MultiDrugInteractionChecker
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