© 201 Amey. A igh reserved NEWS AND VIEWS ies cece one eee Special cage mio eer Seiecicadverirctkae “Derbtecma reaming * StS eaEt ea cee eee a any ve aes Sucioaiaangns! SSatittindeiean © Sy ey ropes eee oe eee sem earn ee eerie cients ner eee See ee SE en Staten ieeeeet ag enone eee eee Ee cares ie eres 2s eee eee a eT a Lenicaeaanan Singotatcomctcicec™ murcmensanence iin Siete tyes iy nae aers oa ae j é | i r I Regulating innate immunity with dopamine and electroacupuncture Sangeeta $ Chavan & Kevin J Tracey ‘Neural creuits ae able to modulate immune responses by detecting inflammatory melatrs and relaying signals ‘back the immune system. Here, in a mouse model of sepss, the authors show that the immune responses can ‘be modulated by elecbascupuncture, which stimulates a neural circult tat results inthe release of dopamine. The ‘mechanism, ke the inflammatory flex, is neither sympathetic nor parasympathetic. Thelt results show a potential ‘ay forward in developing therapies fr sepsis in dopamine agonists (pages 291-295). eceny mpped peripheral seul cits dahil se, es an slen, nese by inds Watkin and her seuetbetourelofetnrooteieriian’ anda Regresrecenicmstrenaier trp ft denoted ht ees ‘yr ya iron vague ie among the owing ite olent fer ntl dian {Dibecanta mene tin Simla free Uncover at dese of he pie Ll requed on ee the say ead gle eds are matoy et tere (fg) Staton of he emery tof he ouging (ceo) nea cnc Pyeogleensinmanlaerapi- sr by thse indanmtery medtr 2c {inte ote mane yen to cote tlhe aretha ate mor earl Sa tha er the tmniyiarel ine The ocrlnmune (vo pnp dion ype uth) mane syn to eet faction DY eles hve bro plead in ming ways pee Unig galing rok erent nearer the ‘Shaw ser experimen statin of seman facton ements puta dena (PA mi ‘hernewalinmneetxcicusstenates the spt and parsmpaei pt Ataon of the HPA vin urna tps [Gionmatie Now inte Toes Rose wey ingenel apa phwsy en hcoreldedewe whore snd cole! epert tht avatn of ate slog repose ch sins peripheral ius repos, The aaa Swaine cet wingalroscaanc exter and boos prem andes eben eal nasi bce ‘eaten inflamma Using ue nngy resale ee’ mane repens ding neon. and Sanda of wp the egos sured rots, I cass parc jr terme nap honensat Snacintonoftiewney science by funee pce cic tat pepe (ig 1). 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Al ih eared NEWS AND VIEWS seein let vagu nerve sig: COMPETING FDNCIAL DTERESTS ‘al nl bod Hery Ble wal Themen cer cmgng nes, radio lan set the scO7 ott a2 8 elite uigudy deel by her tie St ta Bs Phylogrindfancion ir One shot forward for HIV prevention Lawrence Corey & M Juana McEirath ‘The expression of antibodies to protect against an infectious disease canbe achieved by the Inection Int the host of vectors arying the gene tothe relevant antibodies, Here the authors demonstrate the applicability ofthis technique to protection fom HIV in humanized meuse mode, showing this tobe a valid route to pursue in vaccine evelopment fer humans (pages 296-300). eet eels of fncios etibodies dings pov ite ep forma ey em hen poet en cant Ive een he aie for reveing the shovaie concer a een coe eed menue yaad cso of veal nectons Ti topes me ye bean pee pans ced epeton nr pd ‘Soommicaly see by aio of snipe, {ee pox chalenge detected ppg Sr'immonogs ta nduer neuraing "Thee aes uma Bo tha sen nity ws no ane “Sabir fc naccnatoh, Bower, erat moe modelo emule hee arthrmor ie es etectlie “Inet ifson o otes Donees fs nodecee NODISCID mice inpted_dpctn of CDE Teste pen and et ‘veimmanoporys sb porn tobe ws human her nd Uyous tbe and inning hated of ll ‘ec epecaliiornpd pci oma empl vibaaogurhamen calves ocue nama dsp te pee of ‘toed cxpoaetoanineciusgen nce: Cost aemc(BLT mc) Tse ween eearasng ses inthe mon th pte Aer Beery ol is sdistred engl do ofan AAV vcr time a ange I ato, ape HIV ‘Leman Teeoglleic et expen coe oxide uy oeeny dap ratte wee etc san fer Shel vey mace incensed alate brated eraling atin, depen wb aor ce Noviistion sd carscerinion fepoe bade Eaown poppe The genau yim na ca ‘recthssocfomunlyocurg edt oj afastbndes ested pty. unas msc aco expen. {elsingenbodestHI (el) Meer enue HIV college i he humaraed Por at tw dade get ret as Proctor the merengue ma wcocetinr ew 350 Sedped he nf ANY ec poe bode nna prset val ea akg re mp pen tha HIV ie theap nd more cr eee Sreambinntatenasccael Ws AAV) sel wnstiedne peter oxy napatinicines dare. 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