The European Bioinformatics Institute (EMBL-EBI) is a centre for research and services

in bioinformatics, and is part of European Molecular Biology Laboratory (EMBL).

Contents
[hide]

1About

2Funding

3Resources at the EMBL-EBI

4Other bioinformatics organisations

5References

6External links

About[edit]
The roots of the EMBL-EBI lie in the EMBL Nucleotide Sequence Data Library[3][4] (now known as
EMBL-Bank), which was established in 1980 at the EMBL laboratories in Heidelberg, Germany
and was the world's first nucleotide sequence database. [5] The original goal was to establish a
central computer database of DNA sequences, to supplement sequences submitted to journals.
What began as a modest task of abstracting information from literature soon became a major
database activity with direct electronic submissions of data and the need for highly skilled
informatics staff. The task grew in scale with the start of the genome projects, and grew in
visibility as the data became relevant to research in the commercial sector. It soon became
apparent that the EMBL Nucleotide Sequence Data Library needed better financial security to
ensure its long-term viability and to cope with the sheer scale of the task.
There was also a need for research and development to provide services, to collaborate with
global partners to support the project, and to provide assistance to industry. To this end, in 1992,
the EMBL Council voted to establish the European Bioinformatics Institute and to locate it at
the Wellcome Trust Genome Campus in the United Kingdom where it would be in close proximity
to the major sequencing efforts at the Wellcome Trust Sanger Institute. From 1992 through to
1994, a gradual transition of the activities in Heidelberg took place, until in September 1994 the
EMBL-EBI occupied its current location on the Wellcome Trust Genome Campus.
When the EMBL-EBI moved to Hinxton it hosted two databases, one for nucleotide sequences
(the EMBL Data Library, which was renamed EMBL-Bank and eventually became part of
the European Nucleotide Archive) and one for protein sequences (Swiss-ProtTrEMBL, now
known as UniProt). Since then, the EMBL-EBI has diversified to provide data resources in all the
major molecular domains and expanded to include a broad research base. It provides user
support and offers advanced training in bioinformatics. [6]
Since 2013, EMBL-EBI has been listed as a data and service provider in the Registry of
Research Data Repositories.[7]

Funding[edit]

The European Bioinformatics Institute campus at Hinxton.

As part of EMBL, the largest part of EMBL-EBI's funding comes from the governments of EMBL's
21 member states. Other major funders include the European Commission, Wellcome Trust, US
National Institutes of Health, UK Research Councils, EMBL-EBI's industry partners and the UK
Department of Trade and Industry. In addition, the Wellcome Trust provides the facilities for the
EMBL-EBI on its Genome Campus at Hinxton, and the UK Research Councils have provided
funds for EMBL-EBI's facilities in Hinxton.[8]Coordinates: 52447.76N 01112.25E

Resources at the EMBL-EBI[edit]

The EMBL-EBI hosts a number of publicly open, free to use life science resources, including
biomedical databases, analysis tools and bio-ontologies. These include:

ArrayExpress - archive of gene expression experiments

BioModels Database - a database of computational models relevant to the life sciences

BioStudies - a database that serves as a generic data archive at EMBL-EBI for

biomolecular datasets

Chemical Entities of Biological Interest (ChEBI) - database and ontology of molecular

entities

European Nucleotide Archive (ENA) - resource of nucleotide sequencing information

Ensembl project - genome databases for vertebrates and other eukaryotic species (joint
with Wellcome Trust Sanger Institute)

Europe PubMed Central - database offering free access to collection of biomedical

research literature

Experimental Factor Ontology (EFO) - ontology of experimental variables for biomedical

data

Expression Atlas - database of summary information on which genes are expressed

under which conditions

Gene ontology - ontology of gene functions and processes

InterPro - database of protein functional domains and families

MetaboLights - repository of metabolomics data

Protein Data Bank in Europe - European resource for the collection, organisation and
dissemination of data on biological macromolecular structures

Proteomics Identifications Database (PRIDE) - repository of mass spectrometry (MS)

based proteomics

UniProt - database of protein sequence and functional information (joint with Swiss
Institute of Bioinformatics and Protein Information Resource)

Buchnera aphidicola (Brachycaudus rumexicolens) singlestrand binding protein (ssb) gene, partial cds; ssb-dnaB
intergenic spacer, complete sequence; and DnaB (dnaB)
gene, partial cds
GenBank: EU998907.1
FASTA Graphics PopSet
Go to:
LOCUS

EU998907

528 bp

DNA

linear

BCT 26-JUL-

2016
DEFINITION

Buchnera aphidicola (Brachycaudus rumexicolens) single-strand

binding protein (ssb) gene, partial cds; ssb-dnaB intergenic
spacer, complete sequence; and DnaB (dnaB) gene, partial cds.

ACCESSION

EU998907

VERSION

EU998907.1

KEYWORDS

SOURCE

Buchnera aphidicola (Brachycaudus rumexicolens)

ORGANISM

Buchnera aphidicola (Brachycaudus rumexicolens)

Bacteria; Proteobacteria; Gammaproteobacteria;

Enterobacteriales;
Enterobacteriaceae; Buchnera.
REFERENCE

(bases 1 to 528)

AUTHORS

Jousselin,E., Desdevises,Y. and Coeur d'acier,A.

TITLE

Fine scale cospeciation between Brachycaudus and Buchnera

aphidicola: bacterial genome help define species and

evolutionary
relationships in aphids
JOURNAL
REFERENCE

Unpublished
2

(bases 1 to 528)

AUTHORS

Jousselin,E., Desdevises,Y. and Coeur d'acier,A.

TITLE

Direct Submission

JOURNAL

Submitted (06-AUG-2008) CBGP Centre de Biologie et de Gestion

des
Population, Institut National de la Recherche Agronomique
(INRA),
Campus International de Baillarguet, Montferrier sur Lez 34988,
France
FEATURES
source

Location/Qualifiers
1..528
/organism="Buchnera aphidicola (Brachycaudus

rumexicolens)"
/mol_type="genomic DNA"
/host="Brachycaudus rumexicolens (Patch, 1917) voucher
Chasses 1982"
/db_xref="taxon:558011"
gene

complement(<1..14)
/gene="ssb"

CDS

complement(<1..14)
/gene="ssb"
/codon_start=1
/transl_table=11
/product="single-strand binding protein"
/protein_id="ACI15472.1"
/translation="MASRG"

misc_feature

15..449
/note="ssb-dnaB intergenic spacer"

gene

450..>528
/gene="dnaB"

CDS

450..>528
/gene="dnaB"
/codon_start=1
/transl_table=11
/product="DnaB"
/protein_id="ACI15471.1"
/translation="MVYAINMAKNKLYLNQINRLKIPPHS"

ORIGIN
1 cctctactag ccatatcaaa actccacttc taaaatatga aaaaacaaac aatatatttt
61 ataaattttt attatacatc gtaaatattt tatttagtat gatccaaact ataaaaaatg
121 ctatattatt tttaatgtgt taaaaacact attacttaaa ttatgaaaaa ctcttattaa
181 aatgtattct tactaaaaaa tataattatt tttctaaaaa attaaaaatt agataagaaa
241 atatcaataa taaatagtta tatcttataa aaaatcttat agaatacgag aaaaataaaa
301 tcttataagc tatatataaa taatttttta tgcttatatt aatgataaaa aattaaaata
361 aattaaaaaa aggacttaaa tagattagtc cccagatagt gtattattgc aatattacga
421 tatataattt tgtagaaatt aactaaataa tggtatatgc aataaatatg gctaaaaata
481 aattatattt aaatcaaatt aacagattaa aaattccacc acattctt

Buchnera aphidicola (Brachycaudus rumexicolens) singlestrand binding protein (ssb) gene, partial cds; ssb-dnaB
intergenic spacer, complete sequence; and DnaB (dnaB)
gene, partial cds
GenBank: EU998907.1
GenBank Graphics PopSet
>EU998907.1 Buchnera aphidicola (Brachycaudus rumexicolens) single-strand
binding protein (ssb) gene, partial cds; ssb-dnaB intergenic spacer,
complete sequence; and DnaB (dnaB) gene, partial cds
CCTCTACTAGCCATATCAAAACTCCACTTCTAAAATATGAAAAAACAAACAATATATTTTATAAATTTTT
ATTATACATCGTAAATATTTTATTTAGTATGATCCAAACTATAAAAAATGCTATATTATTTTTAATGTGT
TAAAAACACTATTACTTAAATTATGAAAAACTCTTATTAAAATGTATTCTTACTAAAAAATATAATTATT
TTTCTAAAAAATTAAAAATTAGATAAGAAAATATCAATAATAAATAGTTATATCTTATAAAAAATCTTAT
AGAATACGAGAAAAATAAAATCTTATAAGCTATATATAAATAATTTTTTATGCTTATATTAATGATAAAA
AATTAAAATAAATTAAAAAAAGGACTTAAATAGATTAGTCCCCAGATAGTGTATTATTGCAATATTACGA
TATATAATTTTGTAGAAATTAACTAAATAATGGTATATGCAATAAATATGGCTAAAAATAAATTATATTT
AAATCAAATTAACAGATTAAAAATTCCACCACATTCTT