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  • Isonarcotic Activity of Esters, Alcohols, Ketones, and Ethers With Tadpoles

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    Nishith
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    This document presents data on the isonarcotic activity of various esters, alcohols, ketones, and ethers toward tadpoles. It includes the concentration (1/C) needed to immobilize 50% of tadpoles within a certain period of time and the calculated log P values for each compound. A linear regression analysis of all 28 compounds yielded the equation log(1/C) = 0.869 log P + 1.242 with an r-value of 0.965. A second order polynomial regression of just the 10 alcohol compounds gave the equation log(1/C) = 1.49 log P - 0.10 (log P)2 + 0.50 with an r-value

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    Isonarcotic[1]

    Original Title

    Isonarcotic[1]

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    This document presents data on the isonarcotic activity of various esters, alcohols, ketones, and ethers toward tadpoles. It includes the concentration (1/C) needed to immobilize 50% of tadpoles within a certain period of time and the calculated log P values for each compound. A linear regression analysis of all 28 compounds yielded the equation log(1/C) = 0.869 log P + 1.242 with an r-value of 0.965. A second order polynomial regression of just the 10 alcohol compounds gave the equation log(1/C) = 1.49 log P - 0.10 (log P)2 + 0.50 with an r-value

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    © All Rights Reserved
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    7 views1 page

    Isonarcotic Activity of Esters, Alcohols, Ketones, and Ethers With Tadpoles

    Uploaded by

    Nishith
    This document presents data on the isonarcotic activity of various esters, alcohols, ketones, and ethers toward tadpoles. It includes the concentration (1/C) needed to immobilize 50% of tadpoles within a certain period of time and the calculated log P values for each compound. A linear regression analysis of all 28 compounds yielded the equation log(1/C) = 0.869 log P + 1.242 with an r-value of 0.965. A second order polynomial regression of just the 10 alcohol compounds gave the equation log(1/C) = 1.49 log P - 0.10 (log P)2 + 0.50 with an r-value

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    © All Rights Reserved
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    Isonarcotic Activity of Esters, Alcohols, Ketones, and Ethers with Tadpoles

    Compound
    CH3OH
    C2H5OH
    CH3COCH3
    (CH3)2CHOH
    (CH3)3COH
    CH3CH2CH2OH
    CH3COOCH3
    C2H5COCH3
    HCOOC2H5
    C2H5COC2H5
    (CH3)2C(C2H5)OH
    CH3(CH2)3OH
    (CH3)2CHCH2OH
    CH3COOC2H5
    C2H5COC2H5
    CH3(CH2)4OH
    CH3CH2CH2COCH3
    CH3COOCH2C2H5
    C2H5COOC2H5
    (CH3)2CHCOOC2H5

    log(1/C)
    0.30
    0.50
    0.65
    0.90
    0.90
    1.00
    1.10
    1.10
    1.20
    1.20
    1.20
    1.40
    1.40
    1.50
    1.50
    1.60
    1.70
    2.00
    2.00
    2.20

    log P
    -1.27
    -0.75
    -0.73
    -0.36
    0.07
    -0.23
    -0.38
    -0.27
    -0.38
    0.59
    0.59
    0.29
    0.16
    0.14
    0.31
    0.81
    0.31
    0.66
    0.66
    1.05

    Source: S. P. Gupta, Chem. Rev. 1989, 89, 1765-1800

    log(1/C) = 0.869 log P + 1.242

    n = 28

    r = 0.965

    n = 10

    r = 0.995

    subset of alcohols:
    log(1/C) = 1.49 log P - 0.10 (log P)2 + 0.50

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