Calculation of CPZ Equivalents

We convert all antipsychotic doses to chlorpromazine equivalents, using published equivalencies

for oral conventional (American Psychiatric Association 1997) and atypical (Woods 2003)
antipsychotics. For depot haloperidol, fluphenazine, and risperidone, we use the manufacturers
recommended equivalent for the depot to oral conversion for the same drug and then converted
to oral chlorpromazine equivalents. For haloperidol the manufacturer recommends that 10-15
mg per 4 weeks is equivalent to 1 mg/d orally. We use the 15 mg figure. This estimate is
supported by a bioavailability study (mean 14.1 mg depot/4 weeks per 1 mg/d orally) (Nayak et
al 1987). For fluphenazine the manufacturer recommends 12.5 mg depot/3 weeks as equivalent
to 10 mg/d orally. This estimate is supported by a dose comparison study (12.5 mg depot/3 week
equivalent to approximately 9 mg/d orally) (Schooler and Levine 1976). For risperidone, 25 mg
depot/2 weeks per 2 mg/d orally is used (Chue et al 2005).
The following Tables have been created based on the references above.
Table 1. Antipsychotics and Equivalent Doses (sorted by med code)
Proposed Code Trade Name
Generic Name
Equivalent dose
01
Haldol
haloperidol
2 mg per day
02
Thorazine
chlorpromazine
100 mg per day
03
Mellaril
thioridazine
100 mg per day
04
Navane
thiothixene
4 mg per day
05
Risperdal
risperidone (oral)
2 mg per day
06
Zyprexa
olanzapine
5 mg per day
07
Prolixin
fluphenazine (oral)
2 mg per day
08
Stelazine
trifluoperazine
2 mg per day
09
Trilafon
perphenazine
8 mg per day
10
Moban
molindone
10 mg per day
11
Loxitane
loxapine
10 mg per day
12
Compazine
prochlorperazine
15 mg per day
13
Seroquel
quetiapine
75 mg per day
13
Serentil
mesoridazine
50 mg per day
15
Clozaril
clozapine
50 mg per day
17
Geodon
ziprasidone
60 mg per day
17
Haldol dec
haloperidol (depot)
30 mg per 28 days
18
Prolixin dec
fluphenazine (depot)
2.5 mg per 21 days
19
Abilify
aripiprazole
7.5 mg per day
20
Risperdal Consta risperidone (depot)
25 mg per 14 days

Table 2. Antipsychotics and Equivalent Doses (sorted by trade name)

Proposed Code Trade Name
Generic Name
Equivalent dose
19
Abilify
aripiprazole
7.5 mg per day
15
Clozaril
clozapine
50 mg per day
12
Compazine
prochlorperazine
15 mg per day
17
Geodon
ziprasidone
60 mg per day
01
Haldol
haloperidol
2 mg per day
17
Haldol dec
haloperidol (depot)
30 mg per 28 days
11
Loxitane
loxapine
10 mg per day
03
Mellaril
thioridazine
100 mg per day
10
Moban
molindone
10 mg per day
04
Navane
thiothixene
4 mg per day
07
Prolixin
fluphenazine (oral)
2 mg per day
18
Prolixin dec
fluphenazine (depot)
2.5 mg per 21 days
05
Risperdal
risperidone (oral)
2 mg per day
20
Risperdal Consta risperidone (depot)
25 mg per 14 days
13
Serentil
mesoridazine
50 mg per day
13
Seroquel
quetiapine
75 mg per day
08
Stelazine
trifluoperazine
2 mg per day
02
Thorazine
chlorpromazine
100 mg per day
09
Trilafon
perphenazine
8 mg per day
06
Zyprexa
olanzapine
5 mg per day
Table 3. Antipsychotics and Equivalent Doses (sorted by generic name)
Proposed Code Trade Name
Generic Name
Equivalent dose
19
Abilify
aripiprazole
7.5 mg per day
02
Thorazine
chlorpromazine
100 mg per day
15
Clozaril
clozapine
50 mg per day
18
Prolixin dec
fluphenazine (depot)
2.5 mg per 21 days
07
Prolixin
fluphenazine (oral)
2 mg per day
01
Haldol
haloperidol
2 mg per day
17
Haldol dec
haloperidol (depot)
30 mg per 28 days
11
Loxitane
loxapine
10 mg per day
13
Serentil
mesoridazine
50 mg per day
10
Moban
molindone
10 mg per day
06
Zyprexa
olanzapine
5 mg per day
09
Trilafon
perphenazine
8 mg per day
12
Compazine
prochlorperazine
15 mg per day
13
Seroquel
quetiapine
75 mg per day
20
Risperdal Consta risperidone (depot)
25 mg per 14 days
05
Risperdal
risperidone (oral)
2 mg per day
03
Mellaril
thioridazine
100 mg per day
04
Navane
thiothixene
4 mg per day
08
Stelazine
trifluoperazine
2 mg per day
17
Geodon
ziprasidone
60 mg per day

Table 4. Antipsychotics and Equivalent Doses (sorted by equivalent dose)

Proposed Code Trade Name
Generic Name
Equivalent dose
01
Haldol
haloperidol
2 mg per day
05
Risperdal
risperidone (oral)
2 mg per day
07
Prolixin
fluphenazine (oral)
2 mg per day
08
Stelazine
trifluoperazine
2 mg per day
04
Navane
thiothixene
4 mg per day
06
Zyprexa
olanzapine
5 mg per day
19
Abilify
aripiprazole
7.5 mg per day
09
Trilafon
perphenazine
8 mg per day
10
Moban
molindone
10 mg per day
11
Loxitane
loxapine
10 mg per day
12
Compazine
prochlorperazine
15 mg per day
13
Serentil
mesoridazine
50 mg per day
15
Clozaril
clozapine
50 mg per day
17
Geodon
ziprasidone
60 mg per day
13
Seroquel
quetiapine
75 mg per day
02
Thorazine
chlorpromazine
100 mg per day
03
Mellaril
thioridazine
100 mg per day
18
Prolixin dec
fluphenazine (depot)
2.5 mg per 21 days
17
Haldol dec
haloperidol (depot)
30 mg per 28 days
20
Risperdal Consta risperidone (depot)
25 mg per 14 days
References
American Psychiatric Association (1997): Practice Guideline for the Treatment of Patients with
Schizophrenia. American Journal of Psychiatry 154:1-63.
Chue P, Eerdekens M, Augustyns I, et al (2005): Comparative efficacy and safety of long-acting
risperidone and risperidone oral tablets. European Neuropsychopharmacology 15:111-7.
Nayak RK, Doose DR, Nair NP (1987): The bioavailability and pharmacokinetics of oral and
depot intramuscular haloperidol in schizophrenic patients. J Clin Pharmacol 27:144-50.
Schooler NR, Levine J (1976): Initiation of long-term pharmacotherapy in schizophrenia Dosage and side-effect comparisons between oral and depot fluphenazine.
Pharmakopsychiatrie Neuro-Psychopharmakologie 9:159-69.
Woods SW (2003): Chlorpromazine equivalent doses for the newer atypical antipsychotics.
Journal of Clinical Psychiatry 64:663-667.
Scott W. Woods, M.D.
New Haven, Connecticut
November 15, 2005
scott.woods@yale.edu