Gene.

FAP.
Chromosomal
instability type (born
with 1 APC).
APC (TSG).

Prevalence.
Risk of
developing it.

1%.
50% ~ 45 years
100% ~ 60 years

Mutation.

Peptic ulcer disease.

Well demarcated.
Sharp.
Raised lips.
Hyperemic.

HNPCC (Lynch syndrome).

Microsatellite instability
MSH1/MSH2 (DNA mismatch
repair genes that are TSGs).
Loss due to
hypermethylation.
2-3% (most common).
70-80% in 45 years (dont
pick up in screening
program).

Colorectal cancer.
Flattened (destroyed ruggal
folds).
Malignant when passed beyond
muscularis mucosae.