____________________________________ Will Rock the Models in Research Quiz

(Your Name)
Match the type of research models to the descriptions:
1. In Vitro Diagnostics

a. Studying characteristics of certain human populations

2. Non-Human Tissue Culture

b. Using humans as test subjects

3. Human Tissue Culture

Methods

c. Using cells in test tubes to investigate the effects of drugs

or compounds on a specific aspect of normal functions.

4. Computer-Based Modeling

d. Using computers to simulate how drugs may be absorbed

by or react in living organisms.

5. Animal Studies

e. Using animals to evaluate procedures for efficacy and/ or

safety.

6. Clinical Studies

f. Using cells or tissues from non-human organisms to test

new drugs or therapies.

7. Epidemiological Studies

g. Using cells or tissues from humans to test new drugs or

therapies.

Match the level of dependence on animals to each research model. (They may be used more than once).
Level of Dependence on Animals
1. In Vitro Diagnostics
2. Non-Human Tissue Culture
3. Human Tissue Culture
Methods
4. Computer-Based Modeling
5. Animal Studies
6. Clinical Studies
7. Epidemiological Studies

a. Very High
b. High
c. Low
d. Not Applicable

Commented [1]: The layout of the questions alone may end

up confusing students. Misleading layout can be a source of
bias. I would change the layout of the selected response so
that they are consistent from the first to the second page;
place the answer space all the way to the left throughout the
whole quiz, for example.

Commented [2]: A positive of the test is that "like" targets

are grouped together which does help students and teacher
alike quickly see which targets are met or need more work.
Commented [3]: A positive for this section is that the
response options may be used more than once which means
it is impossible for students to arrive at the correct response
purely through elimination. That being said, this type of
question does not allow me to know if students understand
why they depend on animals or not. An open response
question would give me a better understanding of what the
students know or if they are just guessing.
Commented [4]: Students are not given information about
how many points each question is worth. A student may
assume correctly that each question is worth one point, but
does not know that unless the teacher announces that
information. Again, if the model questions incorporated
open-responses, the point values would need adjusting as
the reply would need more weight due to a higher complexity
of questioning being used.

____________________________________ Will Rock the Models in Research Quiz

(Your Name)
Match the types of research models with their benefits.
Benefits
1. Provide predictions for the drugs behavior in humans.
2. Cost is less than clinical studies.

Types of Research Models

a. In Vitro Diagnostics
b. Non-Human Tissue
Culture

3. Eliminates the concern over how the drug will react with humans.
4. Study subjects are human beings.
5. Models allow researchers to investigate very specific functions of
cells or tissues.

c. Human Tissue Culture

Methods
d. Computer-Based
Modeling

6. One tissue sample can provide millions of cells; so many tests can be
conducted using a relatively small amount of tissue.

7. Drugs are actually tested on humans.

e. Animal Studies

Commented [6]: It would be possible to use selected

response for comparative reasoning if the question was redesigned. For example, "Which of the following statements
best describes how In Vitro Diagnostics benefit
researchers..." Or for inference reasoning - "Which answer
best explains why a researcher would select Human Tissue
Culture Methods above another research model?"
Commented [K7]: Again, selected response questions are not
best suited for the following targets as the students need to be
able to elaborate and explain upon these ideas.

f. Clinical Studies
g. Epidemiological Studies

Match the research models with the best matching limitations for each.
Research Models

Commented [5]: Selected response questions are best

used to assess mastery of discrete elements of knowledge.
Limitations, benefits, and the level of dependence each
research model has on animals, can be much more than
specific knowledge. These points incorporate the student's
ability to reason after knowing the characteristics or
definition of each model. These three targets should be met
by using a different assessment method to give a more
accurate and valid picture of what students know.

Limitations

1. In Vitro Diagnostics

a.

Study subjects cannot benefit directly.

2. Non-Human Tissue
Culture

b.

In Vitro studies are cheaper, and take less time.

Animals are not identical to human beings.

3. Human Tissue
Culture Methods

c.

Enrollment in studies is quite low.

Costly and Time-consuming.

4. Computer-Based
Modeling

d.

Only provides predictions.

Model must first be established in animals.
Each model only works for one particular class of drugs.

5. Animal Studies

e.

So specific for a particular biological function that they do not mimic

what happens in life.

6. Clinical Studies

f.

Cultured in an artificial environment.

Human cells/tissues can carry and transmit human diseases.
Difficult to obtain in sufficient quantities.

7. Epidemiological
Studies

g.

Too specific.
Cultured in an artificial environment.
May not behave exactly as human cells.

Commented [8]: Written Response or Personal

Communication may be better options for the targets
addressed in this assessment as both of those methods are
"strong" matches for both knowledge AND reasoning targets.

Commented [9]: This section could still be used as selected

response if you use the limitations as the stem, and the
research models at the response, where the response may
be used more than once. This would remove the possibility
of correct response through the process of elimination.