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  • Cardiovascula R: Out in

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    The document discusses three topics related to cardiovascular health: 1) Laplace's law which describes how vessel wall tension is dependent on the difference between outside and inside pressure over the radius. 2) The renin-angiotensin-aldosterone axis which controls longterm blood pressure through a chain of processes starting with the liver and kidneys and involving renin, angiotensinogen, angiotensin 1, angiotensin 2, and aldosterone. 3) Coronary artery disease which has three types - myocardial infarction, cardiac arrest, and angina pectoris.

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    Cardiovascular.docx

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    The document discusses three topics related to cardiovascular health: 1) Laplace's law which describes how vessel wall tension is dependent on the difference between outside and inside pressure over the radius. 2) The renin-angiotensin-aldosterone axis which controls longterm blood pressure through a chain of processes starting with the liver and kidneys and involving renin, angiotensinogen, angiotensin 1, angiotensin 2, and aldosterone. 3) Coronary artery disease which has three types - myocardial infarction, cardiac arrest, and angina pectoris.

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    4 views1 page

    Cardiovascula R: Out in

    Uploaded by

    scr.vie
    The document discusses three topics related to cardiovascular health: 1) Laplace's law which describes how vessel wall tension is dependent on the difference between outside and inside pressure over the radius. 2) The renin-angiotensin-aldosterone axis which controls longterm blood pressure through a chain of processes starting with the liver and kidneys and involving renin, angiotensinogen, angiotensin 1, angiotensin 2, and aldosterone. 3) Coronary artery disease which has three types - myocardial infarction, cardiac arrest, and angina pectoris.

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    © All Rights Reserved
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    Cardiovascula

    Laplaces law: vessel wall tension is dependent on the difference between


    outside and inside pressure
    o (PressureOut PressureIn) = (Wall Tension) / (Radius)
    Renin-Angiotensin-Aldosterone Axis
    o Controls longterm BP
    o Angiotensinogen is made by the liver in response to corticosteroids,
    estrogen, thyroxin and angiotensin2 levels
    o Kidneys JGA releases renin when there is low BP
    Renin = angiotensinogenase = cleaves angiotensinogen
    angiotensin1
    o ACE is secreted by pulmonary and renal endothelial cells
    Cleaves angiotensin1 angiotensin2 (2 C-terminal residues
    removed)
    o Angiotensin2 = most potent vasoconstrictor; causes increase in total
    peripheral resistance and thus BP
    Also signals adrenal cortexs zonaglomerulosa to release
    aldosterone (acts on DCT and CDs to conserve more Na and
    secrete K = increase in blood volume)
    Coronary Artery Disease (aka Ischemic Heart Disease)
    o 3 types:
    Myocardial infarction = localized area of cardiac muscle (ST
    segment elevated)
    Cardiac arrest = death within 1 hour of symptoms
    Angina pectoris

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