Office Management of Early Pregnancy Loss

LINDA W. PRINE, MD, Beth Israel Residency in Urban Family Medicine at the Institute for Family Health, New York, New York
HONOR MACNAUGHTON, MD, Tufts University Family Medicine Residency at Cambridge Health Alliance,
Malden, Massachusetts

The management of early pregnancy loss used to be based largely in the hospital setting, but it has shifted to the
outpatient setting, allowing women to remain under the care of their family physician throughout the miscarriage
process. Up to 15 percent of recognized pregnancies end in miscarriage, and as many as 80 percent of miscarriages
occur in the first trimester, with chromosomal abnormalities as the leading cause. In general, no interventions have
been proven to prevent miscarriage; occasionally women can modify their risk factors or receive treatment for relevant medical conditions. Unless products of conception are seen, the diagnosis of miscarriage is made with ultrasonography and, when ultrasonography is not available or is nondiagnostic, with measurement of beta subunit of
human chorionic gonadotropin levels. Management options for early pregnancy loss include expectant management,
medical management with misoprostol, and uterine aspiration. Expectant management is highly effective for the
treatment of incomplete abortion, whereas misoprostol and uterine aspiration are more effective for the management
of anembryonic gestation and embryonic demise. Misoprostol in a dose of 800 mcg administered vaginally is effective
and well-tolerated. Compared with dilation and curettage in the operating room, uterine aspiration is the preferred
procedure for early pregnancy loss; aspiration is equally safe, quicker to perform, more cost-effective, and amenable
to use in the primary care setting. All management options are equally safe; thus, patient preference should guide
treatment choice. (Am Fam Physician. 2011;84(1):75-82. Copyright 2011 American Academy of Family Physicians.)

Patient information:
A handout on miscarriage,
adapted from Reproductive Health Access Project,
is provided on page 85.

arly pregnancy loss is most commonly defined as the spontaneous

loss of a pregnancy before 13 weeks
gestation. Other terms include
miscarriage, early pregnancy failure, and
spontaneous abortion. The terms early
pregnancy loss or miscarriage may be
preferred by patients because of the negative
connotations associated with the word failure, and confusion regarding elective versus
spontaneous abortion. Management of early
pregnancy loss has shifted from the hospital
to the outpatient setting, allowing women to
remain under the care of their family physician throughout the miscarriage process.
Miscarriage is very common, with nearly
one in four women experiencing an early
pregnancy loss in her lifetime.1 Approximately 30 percent of all pregnancies end in
miscarriage, although the majority of these
are miscarried before they are recognized.2
The rate of pregnancy loss among clinically
diagnosed pregnancies is 8 to 15 percent.3-6
As many as 80 percent of miscarriages occur
before 12 weeks gestation, with miscarriage rates decreasing sharply after the first
trimester.2,4

Etiology, Risk Factors, Prognosis,

and Prevention
Approximately 50 percent of early pregnancy
losses are caused by chromosomal abnormalities.7 Other etiologies include infection,
reproductive tract abnormalities, exposure to
toxins, and uncontrolled endocrine or autoimmune disease in the mother. The usefulness of diagnostic testing to determine the
etiology of the loss is typically limited, except
in the case of recurrent pregnancy loss.
Factors associated with early pregnancy
loss are listed in Table 1.2,4,7-22 Preconception
counseling should include a review of modifiable risk factors, and women experiencing
miscarriage should be reassured about the
factors not associated with early pregnancy
loss (Table 2).23-27
Approximately one-fourth of all pregnancies are complicated by bleeding before
20 weeks gestation, and 12 to 57 percent of
these pregnancies end in miscarriage.5,6,28
Although studies consistently support the
finding that heavy vaginal bleeding is associated with an increased risk of pregnancy
loss, several studies have found that spotting
or light bleeding does not increase risk.6,10,29

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Early Pregnancy Loss

SORT: KEY RECOMMENDATIONS FOR PRACTICE
Clinical recommendation
Transvaginal ultrasonography is a reliable way to differentiate between viable and nonviable
pregnancies and should be performed when early pregnancy loss is suspected.
Because better mental health outcomes result when patient preferences for treatment are respected
and because all treatment options are safe, expectant management, medical management with
misoprostol (Cytotec), and uterine aspiration should be offered to women for the treatment of early
pregnancy loss.
Given that expectant management is up to 90 percent effective, it is a reasonable first-line option for
incomplete abortion.
Compared with expectant management, medical management with misoprostol hastens completed
abortion, especially in cases of anembryonic gestation and embryonic demise.
Compared with dilation and curettage in the operating room, uterine aspiration is the preferred
procedure for early pregnancy loss because aspiration is equally safe, quicker to perform, more costeffective, and amenable to use in the primary care setting.
There is insufficient evidence to recommend routine antibiotic prophylaxis following uterine aspiration.
Women experiencing early pregnancy loss should be reassured that subsequent fertility is not
adversely affected by any of the three treatment options (expectant care, medical management
with misoprostol, or uterine aspiration).

Evidence
rating

References

39, 40

46-52

47, 50

50, 51

54-56

C
B

57
59

A = consistent, good-quality patient-oriented evidence; B = inconsistent or limited-quality patient-oriented evidence; C = consensus, diseaseoriented evidence, usual practice, expert opinion, or case series. For information about the SORT evidence rating system, go to http://www.aafp.
org/afpsort.xml.

The risk of pregnancy loss in symptomatic and asymptomatic pregnancies drops once fetal cardiac activity has
been demonstrated on ultrasonography. In pregnant
women presenting with first-trimester bleeding, the presence of fetal cardiac activity decreases the likelihood of

Table 1. Factors Associated with Early

Pregnancy Loss
Advancing maternal age
Alcohol use (moderate)
Caffeine use (with dose-response)
Cigarette smoking (more than 10 cigarettes per day)
Cocaine use
Maternal chronic diseases: antiphospholipid antibody
syndrome, polycystic ovary syndrome, possibly celiac
disease, thyroid disease, or uncontrolled diabetes mellitus
Maternal infections: Chlamydia (conflicting evidence), Listeria,
syphilis, toxoplasmosis, vaginal Mycoplasma or Ureaplasma
Medications: itraconazole (Sporanox), methotrexate,
nonsteroidal anti-inflammatory drugs, paroxetine (Paxil),
retinoids, venlafaxine (Effexor)
Obesity
Previous early pregnancy loss
Reproductive tract abnormalities: congenital uterine
anomalies, leiomyoma, shortened cervix, uterine adhesions
Toxins and occupational exposures: ionizing radiation,
pesticides, unscavenged anesthetic gases
Information from references 2, 4, and 7 through 22.

76 American Family Physician

early pregnancy loss to approximately 10percent.10,30 In

asymptomatic pregnancies with demonstrated fetal cardiac activity, the chance of miscarriage is 9 percent at six
weeks gestation and 0.5 percent at nine weeks gestation.31
Beyond addressing modifiable risk factors and treating
underlying maternal chronic conditions, no interventions have been shown to prevent miscarriage. In particular, Cochrane reviews have found that miscarriage is
not prevented by bed rest, vitamin supplementation, or
progestogen use,32-34 and that threatened abortion is not
effectively treated with uterine muscle relaxants, progestogen, or human chorionic gonadotropin.35-37 Although
some interventions exist to prevent recurrent pregnancy
loss, they are beyond the scope of this article.

Table 2. Miscarriage Myths: Factors Mistakenly

Associated with Early Pregnancy Loss
Air travel
Blunt abdominal trauma
Contraceptive use (including oral contraceptives, intrauterine
devices [before pregnancy], implants, spermicides)
Exercise (continuing exercise at prepregnancy levels)
Human papillomavirus vaccination (bivalent 16/18)
Previous first-trimester elective abortion
Sexual activity
Stress
Information from references 23 through 27.

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Early Pregnancy Loss

Table 3. Definitions and Ultrasound Findings in Subcategories of Early Pregnancy Loss
Subcategory

Definition

Ultrasound characteristics

Anembryonic
gestation

Pregnancy in which a gestational sac develops

without development of any embryonic
structures; previously referred to as an empty
sac or blighted ovum

Gestational sac > 13 mm without yolk sac or

> 18 mm without embryonic pole, or empty
sac beyond 38 days gestation and no interval
growth over one week

Complete abortion

All products of conception have passed

Empty uterus; endometrial lining may be thickened

Ectopic pregnancy

Any pregnancy outside of the endometrium;

most commonly in the fallopian tube, but may
also be in the cervix, cornua, ovary, or abdomen

Empty uterus; may see complex/cystic adnexal mass

or fluid in cul-de-sac; embryo with cardiac activity
is diagnostic but rarely seen

Embryonic or fetal
demise

Pregnancy loss after the development of embryo

or fetus; cervix closed and bleeding not present;
also referred to as missed abortion

Embryonic pole 5 mm without fetal cardiac

activity, or embryonic pole < 5 mm and no interval
growth over one week

Incomplete abortion

Some, but not all, of the products of conception

have passed

Heterogeneous and/or echogenic material along

endometrial stripe or in cervical canal

Inevitable abortion

Cervix has dilated but passage of products has

not occurred, and miscarriage is unavoidable;
usually in setting of vaginal bleeding

Products of conception visible; fetal cardiac activity

may or may not be present

Recurrent abortion

Three or more consecutive pregnancy losses

Septic abortion

Incomplete abortion associated with ascending

infection of the endometrium, parametrium,
adnexa uteri, or peritoneum

Findings consistent with incomplete abortion

Threatened abortion

Bleeding before 20 weeks gestation with closed

cervix; pregnancy viable at time of presentation
and may or may not miscarry

Findings appropriate for stage of pregnancy;

subchorionic hemorrhage may be present

Diagnosis
Early pregnancy loss is divided into subcategories that
are defined by a combination of clinical and ultrasound
findings1 (Table 3). Women experiencing a miscarriage
can present to their family physician in a number of
ways, including with vaginal bleeding, absent fetal heart
tones on Doppler, size-dates discrepancy on bimanual
examination, or a routine ultrasonography indicating a
nonviable pregnancy. Patients with vaginal bleeding that
is not self-limited should be assessed for signs and symptoms of hemodynamic instability, although this is rare.
A baseline complete blood count is warranted in most
cases. Physical examination should routinely include a
bimanual examination for size-dates discrepancy and
extrauterine tenderness or masses that may indicate
ectopic pregnancy or rupture. Speculum examination
can be diagnostic if the products of conception are visible in the cervical os or vaginal vault.
In the absence of visible tissue or an open cervical os,
miscarriage must be differentiated from a viable intrauterine pregnancy or ectopic pregnancy by ultrasonography, serial beta subunit of human chorionic gonadotropin
(-hCG) levels, or both.38-40 Transvaginal ultrasonography is the most reliable way to differentiate between viable
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and nonviable pregnancies, and should be performed

when early pregnancy loss is suspected.39,40 A gestational
sac should be visible on transvaginal ultrasonography at
-hCG levels of 1,500 to 2,000 mIU per mL.41 This -hCG
level is known as the discriminatory zone and depends on
the quality of the machine and the skill of the sonographer. In a normal pregnancy, the discriminatory zone is
reached at approximately five weeks gestation.
When a woman presents with vaginal bleeding during
a wanted pregnancy and the initial ultrasonography is
nondiagnostic, caution should be exercised when confirming the diagnosis with serial ultrasonography and
-hCG measurements because making the diagnosis can
be challenging in some cases (Figures 142 and 242). Whenever possible, serial -hCG levels should be analyzed by
the same laboratory to avoid interlaboratory variability.
Assuming that an ectopic pregnancy has been ruled out,
there is no urgency to intervene; physicians should allow
the patient to process the news at her own pace.
Many small, portable ultrasound machines are now
available, making office diagnosis of miscarriage possible and saving women the anxiety and wait of an emergency department or radiology visit. Several studies
support office use of ultrasonography, demonstrating

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American Family Physician 77

Early Pregnancy Loss

Evaluation of First-Trimester Bleeding

Bleeding in desired pregnancy, < 12 weeks gestation

Physical examination

Peritoneal signs
or hemodynamic
instability

Transfer to
emergency
department

Nonobstetric cause
of bleeding identified

Products of conception
visible on examination

Diagnose
and treat as
indicated

Incomplete
abortion, treat
as indicated

Ectopic pregnancy or
signs suggestive of
ectopic pregnancy

Presume ectopic
pregnancy; refer for
high-level TVUS*
and/or treatment

Patient stable, no products

of conception or other
cause of bleeding

TVUS

Viable IUP

Nonviable IUP

Threatened abortion;
repeat TVUS if
further bleeding

Embryonic demise,
anembryonic gestation,
or retained products
of conception; discuss
treatment options

IUP, viability
uncertain

No IUP, no ectopic
pregnancy seen

Repeat TVUS in one

week and/or follow
serial -hCG levels

IUP seen on prior TVUS?

No
Obtain -hCG
level immediately;
see Figure 2

Yes
Completed
abortion;
expectant
management

*High-level TVUS entails a formal ultrasonography by radiology.

Figure 1. Algorithm for the evaluation of first-trimester bleeding. (-hCG = beta subunit of human chorionic gonadotropin; IUP = intrauterine pregnancy; TVUS = transvaginal ultrasonography.)
Adapted with permission from the Reproductive Health Access Project. First trimester bleeding algorithm. http://www.reproductiveaccess.org/m_m/
downloads/First_trimester_bleeding_algorithm.pdf. Accessed April 29, 2011.

that family physicians can perform first-trimester ultrasonography with equivalent skill to radiologists and
obstetricians.43-45 If ultrasonography is not immediately
available and the patient is stable, an urgent quantitative -hCG measurement can be done as the initial step
in the workup. The patient should be warned of the
symptoms of ectopic pregnancy that warrant a call to
the physician or a visit to the emergency department. If
the quantitative -hCG level is greater than the 1,500 to
2,000 mIU per mL discriminatory zone, an urgent ultrasonography should be arranged to rule out an ectopic
pregnancy and assess viability. If below the discriminatory zone, serial -hCG levels can be followed every 48
hours until the discriminatory threshold is reached or
until the diagnosis is clear from the trend of the -hCG
levels (Figure 242).
78 American Family Physician

Treatment
Three options exist for treating first-trimester miscarriage: expectant management, medical management
with misoprostol (Cytotec), and uterine aspiration. All of
these options are safe but have varying degrees of success
depending on the type of miscarriage, and the patient
should be informed of these data.46-50 Expectant management is highly effective for the treatment of incomplete
abortion, whereas misoprostol and uterine aspiration
are more effective for the management of anembryonic
gestation and embryonic demise.46-51 An effectiveness
comparison of expectant versus medical management of
various types of miscarriage is presented in Table 4.47,49
After being counseled on her options, the patient should
be allowed to select her treatment.52 Urgent aspiration
should be performed only if she is having brisk bleeding,

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Early Pregnancy Loss

Evaluation of First-Trimester BleedingNo Intrauterine Pregnancy on Ultrasonography
Continued from Figure 1

No IUP or ectopic pregnancy seen on TVUS

IUP seen on prior TVUS?

Yes

No

Completed abortion;
expectant management
-hCG > 1,500 to 2,000 mIU per mL*

Serial -hCG levels

increasing and
> 1,500 to 2,000
mIU per mL*

Single -hCG >

1,500 to 2,000
mIU per mL* and
bleeding history
not consistent
with having
passed products
of conception

-hCG < 1,500 to 2,000 mIU per mL*

Ectopic pregnancy precautions,

repeat -hCG in 48 hours

Single -hCG > 1,500 to 2,000

mIU per mL* and bleeding
history consistent with having
passed products of conception

Repeat -hCG < 1,500

to 2,000 mIU per mL*

Repeat -hCG > 1,500

to 2,000 mIU per mL*

Ectopic pregnancy precautions,

repeat -hCG in 48 hours
Repeat TVUS; see TVUS in Figure 1

Repeat -hCG
decreased < 50
percent or increased

If not already performed, obtain high-level TVUS to

differentiate among ectopic pregnancy, early IUP, and
retained products of conception; treat as indicated

Repeat -hCG
decreased
> 50 percent

Repeat -hCG
decreased
> 50 percent

Suggests completed abortion;

ectopic pregnancy precautions,
follow -hCG weekly to zero

Repeat -hCG decreased

< 50 percent, plateaued,
or increased < 66 percent

Suggests early pregnancy

failure or ectopic
pregnancy; offer uterine
aspiration or serial
-hCG levels with or
without high-level TVUS
until definitive diagnosis
or -hCG is zero

Repeat -hCG
increased > 66
percent

Suggests viable
pregnancy, but not
diagnostic; follow
-hCG until 1,500
to 2,000 mIU per
mL,* then TVUS for
definitive diagnosis

*The -hCG level at which an IUP should be seen on TVUS is referred to as the discriminatory zone, and varies between 1,500 and 2,000 mIU per
mL depending on the machine and the sonographer; knowledge of the discriminatory zone for a particular machine and sonographer is necessary
for appropriate triage of results in this range.
High-level TVUS entails a formal ultrasonography by radiology.
-hCG needs to be followed to zero only if ectopic pregnancy has not been reliably excluded; if a definitive diagnosis of completed miscarriage
has been made, there is no need to follow further -hCG levels.

Figure 2. Algorithm for the evaluation of first-trimester bleeding when no intrauterine pregnancy is seen on ultra
sonography. (-hCG = beta subunit of human chorionic gonadotropin; IUP = intrauterine pregnancy; TVUS = transvaginal ultrasonography.)
Adapted with permission from the Reproductive Health Access Project. First trimester bleeding algorithm. http://www.reproductiveaccess.org/m_m/
downloads/First_trimester_bleeding_algorithm.pdf. Accessed April 29, 2011.

has had prolonged bleeding with a substantial drop in

hemoglobin levels, or is showing signs of infection.
EXPECTANT MANAGEMENT

Many women will first elect to take a wait and see

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Volume 84, Number 1

riage without intervention. For incomplete abortion,

the success rate of this approach is up to 90 percent,
although it may take weeks for complete passage of the
tissue.47 A follow-up appointment to assess completion of
the miscarriage and to process the experience is important. A repeat ultrasonography showing the absence of a

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Early Pregnancy Loss

previously documented pregnancy or an

80 percent drop in the -hCG level one
week following the passage of tissue confirms completion. If using -hCG levels,
there is no need to follow them to zero
unless ectopic pregnancy has not been
reliably excluded. However, for cases in
which an intrauterine pregnancy has not
been documented, it is prudent to follow -hCG levels to resolution because
ectopic pregnancies can present with
declining -hCG levels. In the absence
of hemorrhage or infection, there is no
limit to how long it is safe to wait for the
miscarriage to complete naturally. If a
patient decides that she wants the process
to be over, however, she can switch from
expectant care to medical management or
an aspiration procedure at any point.

Table 4. Rates of Successfully Completed Miscarriage Using

Expectant Management or Misoprostol by Subcategory of
Early Pregnancy Loss
Completed miscarriage with
expectant management (%)
Subcategory of early
pregnancy loss

By day
7*

By day
14*

By day
46*

Completed miscarriage
after taking misoprostol
(Cytotec) by day 8* (%)

Incomplete abortion
Embryonic demise
Anembryonic
gestation
All categories

53
30
25

84
59
52

91
76
66

93
88
81

40

70

81

84

*From day of diagnosis.

Information from references 47 and 49.

MEDICAL MANAGEMENT

Numerous studies have shown misoprostol, a prostaglandin analogue, to be a safe and effective treatment
for early pregnancy loss.48-51 One evidence-based protocol includes 800 mcg of misoprostol vaginally with
a repeat dose in 48 hours, if needed.49 Studies comparing a variety of doses and routes of administration have
found that lower doses and oral administration are
less effective, and sublingual administration is associated with greater adverse effects.51 Ongoing studies
continue to search for the optimal doses and routes of
administration.53
When women choose medical management, the
miscarriage process usually evolves more quickly and
predictably than with expectant management.50,51
Cramping and bleeding typically occur within two to
six hours of misoprostol insertion, with the most severe
symptoms resolving in about three to five hours. Pretreatment with a nonsteroidal anti-inflammatory drug
before administering the misoprostol is helpful to block
the adverse effects of fever, chills, and severe cramping,
and a combination narcotic/acetaminophen should also
be prescribed. As with expectant management, a followup appointment is important to document completion.
A take-home instruction sheet for patients using misoprostol is available at http://www.reproductiveaccess.
org/m_m/MiscarriageUsingMeds.htm.
UTERINE ASPIRATION

Uterine aspiration with a manual vacuum is a safe and

effective procedure amenable to the primary care set80 American Family Physician

ting.54 The steps are similar to those of an endometrial

biopsy, although a paracervical block is indicated and
some dilation of the cervix may be needed. For early
pregnancy loss, an office-based manual uterine aspiration is less painful55 and reduces the cost and scheduling
difficulties associated with dilation and curettage in the
operating room.56 Other benefits of using manual uterine
aspiration rather than dilation and curettage are that the
aspirator is portable and easy to use, the vacuum is quiet,
and the procedure can be completed quickly. A patient
information handout for the treatment of miscarriage
using an aspiration procedure is available at http://www.
reproductiveaccess.org/m_m/InfoAfterAspiration.htm.
Care Following Early Pregnancy Loss
Following pregnancy loss, antibiotics are indicated only
if infection is suspected. It is important to remember that
misoprostol may cause fever within 24 hours of its use,
and that this should not be interpreted as a sign of infection. A Cochrane review found insufficient evidence to
support routine antibiotic prophylaxis following uterine
aspiration.57 If prophylactic antibiotics are used, a onetime dose is preferred, considering poorer compliance is
likely with extended regimens.57
Rh-negative women with any bleeding before 20 weeks
gestation are commonly given RhO (D) immune globulin
(RhoGam) to suppress Rh alloimmunization. Although
there is no direct evidence to support this practice in
very early pregnancy, it remains the standard of care in
the United States. The dose of RhO (D) immune globulin
is 50 mcg (250 IU) in women with bleeding before 12
completed weeks gestation.58

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Early Pregnancy Loss

Women with heavy bleeding or signs and symptoms

of anemia should have their hemoglobin level checked.
If they are found to be anemic, they should receive iron
supplementation.
Patients who do not desire an immediate subsequent
pregnancy should be offered effective contraception,
whereas women planning to conceive again should receive
routine preconception counseling. There is no evidence
to suggest that waiting a certain number of cycles before
attempting another pregnancy is medically necessary.
Regardless of management choice, all women experiencing an early pregnancy loss should be counseled
about when and how to contact their physician. Patients
should be counseled to call their physician if they have
heavy bleeding or signs of endometritis. Heavy bleeding
can be quantified for patients as soaking through two
sanitary pads per hour for two hours in a row. If a patient
calls during the miscarriage process, careful questions
about the degree of soaking of pads or about the relation
of fever to misoprostol use often reveal that the woman is
experiencing a normal process. Recommending another
dose of a nonsteroidal anti-inflammatory drug, with a
follow-up call in one hour, is often sufficient to assess her
safety and reassure her. Symptoms of retained products
of conception or endometritis include high fever, heavy
bleeding, pelvic pain, or feeling ill several days after the
miscarriage. These symptoms warrant an office visit.
Psychological Issues
A miscarriage can be traumatic for a woman and her
family, even if the pregnancy was not highly desired.
Reassurance that she did not bring on the miscarriage
with routine activities is an important component of
counseling. It can be helpful to normalize feelings of
sadness, relief, or mixed emotions that may result. It is
also important that the woman be an active participant
in her miscarriage management, because better mental health outcomes have been associated with having
had a choice in the treatment process.52 She should be
reassured that all of the treatments for miscarriage are
safe and that the choice of treatment will not affect her
future fertility.59
Online sources including Essential Evidence Plus, PubMed,
The Cochrane Library, Clinical Evidence, DynaMed, TRIP Database, the
Database of Abstracts of Reviews of Effects, and the National Guideline
Clearinghouse were searched using the terms spontaneous abortion,
miscarriage, and early pregnancy loss. Reference lists of retrieved
articles and reviews also were used. The highest level of evidence found
for each specific topic was included. Search date: June 2010.
DATA SOURCES:

The authors thank Marji Gold, MD; Ruth Lesnewski, MD; Rebecca
Simons, MD; and Finn Schubert for their assistance in the preparation of
the manuscript.

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Volume 84, Number 1

The Authors
LINDA W. PRINE, MD, is a faculty member at the Beth Israel Residency in
Urban Family Medicine at the Institute for Family Health, New York, NY,
and an associate clinical professor at Albert Einstein College of Medicine
of Yeshiva University, Bronx, NY.
HONOR MACNAUGHTON, MD, is a faculty member at Tufts University
Family Medicine Residency at Cambridge Health Alliance, Malden, Mass.,
and an assistant clinical professor in the Department of Family Medicine
at Tufts University School of Medicine, Boston, Mass.
Address correspondence to Linda W. Prine, MD, Beth Israel Residency
in Urban Family Medicine at the Institute for Family Health, 16 East 16th
St., New York, NY 10003 (e-mail: lindaprine@mac.com). Reprints are
not available from the authors.
Author disclosure: No relevant financial affiliations to disclose.
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Volume 84, Number 1

July 1, 2011