18OHCI-IFBC(1-2)

16/8/02

11:15 AM

Page 2

Paediatric normal ranges

Haemostasis
Parameter
Neonate
Platelet count
150400 109/L
Prothrombin time
few sec longer than adult
APTT
up to 25% increase
Thrombin time
Bleeding time
210 min
Fibrinogen
2.04.0g/L
Vitamin K dependent factors
Factor II
3050% adult level
Factor VII
3050% adult level
Factor IX
2050% adult level
Factor X
3050% adult level
Factor V
Factor VIII
Variable: 50200% adult level
vW Factor
usually raised (up to 3 adult level)
Factor XI
2050% adult level
Factor XII
2050% adult level
Factor XIII
50100% adult level
FDP/XDP
up to twice adult level
AT
5080% adult level
Protein C
3050% adult level
Protein S
3050% adult level
Plasminogen
3080% adult level

Adult level
as adult
up to 1 week
by 29 months
as adult
as adult
as adult
up to 6 months
by 1 month
up to 6 months
up to 6 months
as adult

612 months
36 months
1 month
by 7 days
612 months
up to 24 months
36 months
2 weeks

Adapted from Provan et al. (1998), Oxford Handbook of Clinical Haematology, Oxford University
Press, Oxford (with permission)

Normal FBC values at various ages from birth to 12 years

Age
Birth cord blood
13 days
1 week
2 weeks
1 month
26 months
0.52 years
26 years
612 years

Hb
(g/dL)

Hct
(l/L)

13.519.5
16.021.0
15.219.8
14.019.0
11.916.1
10.512.5
10.513.5
11.513.5
11.515.5

0.420.60
0.450.67
0.420.66
0.390.63
0.310.55
0.280.42
0.330.39
0.340.40
0.350.45

MCV
WBC Neutro- Lympho 109/L)
(fl) (
phils
cytes
109/L) (
109/L)
(
98118
930.0
626.
211.0
95121 9.434.0
521.
211.5
88126
521.0 1.5010.
217.0
86124
520.0
19.5
217.0
85123
519.5
19.0 2.516.5
86102
617.5
18.5
413.5
7086
617.5 1.58.5
410.5
7587 5.515.5 1.58.5
28.00
7795 4.513.5 1.58.0 1.56.80

*Guidelines only: wide range in first weeks of life. Platelet count as adult.
Reference: Hinchliffe & Lilleyman, eds (1987)) Practical Paediatric Haematology, John Wiley & Sons,
Chichester.
Adapted from Provan et al (1998), Oxford Handbook of Clinical Haematology, Oxford University
Press, Oxford (with permission)