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  • CKD, Dialysis and Transplantation

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    Luke McElroy
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    CKD can have various causes including genetic factors and hypertension, and affects males more than females. It impacts salt, water, acid-base and mineral balances in the body as kidney function declines. Estimated GFR is used to assess kidney function status in 5 stages from normal to kidney failure, though isotope clearance is more accurate. Treatment aims to define the cause, slow progression, prevent complications, ensure smooth transition to dialysis or transplant, modify cardiovascular risk, and handle drugs and toxins carefully. Transplantation is the definitive treatment for kidney failure.

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    Ckd

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    CKD can have various causes including genetic factors and hypertension, and affects males more than females. It impacts salt, water, acid-base and mineral balances in the body as kidney function declines. Estimated GFR is used to assess kidney function status in 5 stages from normal to kidney failure, though isotope clearance is more accurate. Treatment aims to define the cause, slow progression, prevent complications, ensure smooth transition to dialysis or transplant, modify cardiovascular risk, and handle drugs and toxins carefully. Transplantation is the definitive treatment for kidney failure.

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    14 views1 page

    CKD, Dialysis and Transplantation

    Uploaded by

    Luke McElroy
    CKD can have various causes including genetic factors and hypertension, and affects males more than females. It impacts salt, water, acid-base and mineral balances in the body as kidney function declines. Estimated GFR is used to assess kidney function status in 5 stages from normal to kidney failure, though isotope clearance is more accurate. Treatment aims to define the cause, slow progression, prevent complications, ensure smooth transition to dialysis or transplant, modify cardiovascular risk, and handle drugs and toxins carefully. Transplantation is the definitive treatment for kidney failure.

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    © All Rights Reserved
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    CKD, Dialysis and Transplantation

    If young think genetic.


    Male>female
    Asians and Hispanic more common.
    Salt and water balance. Hypertension can cause and drive.
    Acid base balance chronic metabolic acidosis with advanced disease
    Excretion vulnerable to things building up
    EPO anaemia
    Vitamin D (1alfahydroxylase for vit d metabolism)
    Assess
    eGFR (really accurate is isotope clearance and used in transplant workup)
    Creatinine is derived from muscle creatine. Lots of things change eGFR.
    MDRD equation in the UK. Normalised to 1.73m2 body surface area.
    Stage 1-5, normal to ESRD. >90 - <15
    Manage:
    Define cause
    Slow progression
    Prevent complications
    Ensure smooth transition to renal replacement
    Modify CV risk
    Drugs can be poisonous and cause allergy in the kidney alone. Dont
    assume progression. May be acute on chronic and require active
    treatment.
    Transplant definitive treatment

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