Chronic Renal

Failure
 Group 1
1 Short text 5 Short text

2 Short text 6 Short text

3 Short text 7 Short text

4 Short text 8 Short text

 Definition & History
Chronic renal failure (CRF) is a failure of kidney function to
maintain metabolism and fluid and electrolyte balance due to
progressive destruction of kidney structures with
manifestations of metabolites (toxicuremic) in the blood.
Kidney failure occurs when the kidneys are unable to
transport the body's metabolic wastes or perform their
regulatory functions. A substance that is normally eliminated
in the urine accumulates in body fluids due to impaired renal
excretion and causes impaired endocrine and metabolic
functions of fluids, electrolytes and acid-base.
Prevalency
 Mechanism of
disease
Condition gradual decline in
kidney function  Azotemia 
Glemerulophritis  Infection
 Symptoms
General Symptoms
• Increased urination,especially at night
• Foamy or bubbly urine(indicates proteins are present in the urine)
• Urine that is cloudy or tea-coloured

Specifik Symptoms
• Puffy eyes,hands,and feet (called edema)
• High blood pressure
• Fatigue
• Nausea and vomiting
• Shortness of breath
• Loss of appetite
www.Medbreaddcast.com/condition/getcondition/chronic-renal-failur
 Methode and equipment
examination Methode equipment

ureum Urease-gldh ( glutamate reagent

dehydrogenation) R1 :TRIS, 2-oxoglutalate,
enzymatic UV test ADP, urease, and
glutamate dehydrogenase
(GLDH)
R2 : nicotinamide adenine
dinucleotide + hydrogen
(NHDH)

and biolyzer 100

creatinin Jaffe method Reagent

R1: sodium hydroxide
R2 : picric acid

and biolyzer 100

 Labs Results
Chronic Renal Failure (CFR) is defined as an estimated
glomerular filtration rate (eGFR) less than <60
ml/minutes/1,73 m2, persisting for 3 months or more,
irrespective of the cause. CFR classifies into 5 categories
based on glomerular filtration rate (G1, G2, G3, G4, to
G5).

Also if serum creatinine value >1,5 mg/dL is indicated

having Chronic Renal Failue

NCBI Chronic Renal Failure, https://www.ncbi.nlm.nih.gov/books/NBK535404/

 Management care
PREVENTION AFTER PREVENTION
Avoid drug abuse. Carry out hemodialysis therapy.
Maintain adequate body fluids by drinking adequate Diabetic patients are treated only by doctors who
amounts of water to maintain a good urine output modify treatment with the aid of HbA1C
rate. (glycosylated hemoglobin) readings taken once
every three months.

Maintain personal hygiene, especially in the urinary Take iron supplements.

tract so that there is no blockage or obstruction.
Check your blood pressure once a week. Perform a blood transplant.
Control your diet or maintain a healthy diet and Follow a low protein diet to reduce waste in the
exercise on a regular basis. blood.
Follow recommended treatments for chronic The use of drugs is a diuretic.
diseases such as diabetes, lupus, and hypertension.
 Conclusion
 Chronic renal failure is a progressive and
slow (continuous in a few years) disease
beginning with : renal backup, kidney
inphysiology, kidney failure , end level
kidney disease accompanied by
complications of organs targets, and
ultimately leads to death.
 To slow chronic renal failure into
terminal kidney failure, early diagnosis is
necessary,whit clinical overview, a simple
laboratory, and immediate
improvemennts in the complications.
Thank You
Any Questions ?