MEFENAMIC ACID

Dosage: Acute Pain

Initial 500 mg PO once, THEN
250 mg PO q6hr PRN usually not to exceed 7 days
Primary Dysmenorrhea
Initial 500 mg PO once, THEN
250 mg PO q6hr PRN usually not to exceed 3 days

Nursing Management:
-take with food to avoid GI effect
-take with 8-12oz water

Contraindicated:
apixaban
benazepril
captopril
enalapril
fosinopril
ketorolac
ketorolac intranasal
lisinopril
methotrexate
moexipril
pemetrexed
perindopril
quinapril
ramipril
tacrolimus
trandolapril

SIDE EFFECT:
Abdominal pain, Anorexia, Diarrhea, Flatulence, Constipation
MECHANISM OF ACTION:
Mefenamic Acid is a potent inhibitor of prostaglandin synthesis in vitro. Mefenamic Acid concentrations reached
during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of
bradykinin in inducing pain in animal models. Prostaglandins are mediators of inflammation. Because Mefenamic
Acid is an inhibitor of prostaglandin synthesis, its mode of action may be due to a decrease of prostaglandins in
peripheral tissues.

CLASSIFICATION:
anti-inflammatory, and antipyretic properties