Professional Documents
Culture Documents
Susan Bonner-Weir
100
75
6
50
7
4
25
8
0
Lean
Lean
Obese
Obese
Diabetic
Diabetic
1
16
30
19
16
41
0
Lean Obese
Obese
Lean Obese
Nondiabetic
IGT
Diabetic
Butler AE, et al. Diabetes. 2003;52:102-10.
Can a given β-cell mass put out much more insulin?
Absolutely!
With obesity, β-cell mass is only 30- 50% increased,
but insulin secretory output increased 100%.
(24 hr output of insulin: 468 versus 235 nmol)
Camastra S, et al. Diabetes 54:2382, 2005
Non diabetic
Insulin requiring diabetic
Non-insulin requiring diabetic
Neogenesis
(from progenitor
or stem cell)
β cell volume
Hypertrophy vs atrophy
Human islets are 70% β cells and are 1-2% of pancreas
Neogenesis
(from progenitor
or stem cell)
β cell volume
Hypertrophy vs atrophy
β cell mass is dynamic and is regulated to
maintain glucose homeostasis.
Insulin
Ki67
Dapi
1. Increased apoptosis
125
100
Normal
%
75
T2DM: Model #2
?Low birth weight
50
0
30
Time (years)
60
• While most of what we know about β cell mass
comes from rodents, human β cells have same
processes of growth and death.