ABSTRACT

The Illinois Junior Academy of Science

This form/paper may not be taken without IJAS authorization.

CATEGORY Health Science STATE REGION # 6

SCHOOL Niles North High School IJAS SCHOOL # 6038
CITY/ZIP Skokie, IL 60077 SCHOOL PHONE # 847.626.2254
SPONSOR Christi Camel

MARK ONE: EXPERIMENTAL INVESTIGATION DESIGN INVESTIGATION

NAME OF SCIENTIST* Sumona Banerjee GRADE 11

NAME OF SCIENTIST GRADE
NAME OF SCIENTIST GRADE
NAME OF SCIENTIST GRADE

* If this project is awarded a monetary prize, the check will be written in this scientist's name, and it will be his/her responsibility to distribute the
prize money equally among all participating scientists.

PROJECT TITLE A Comparison of Sirolimus and Paclitaxel

Purpose: The purpose of this project is to compare the effectiveness of the drugs sirolimus and paclitaxel in reducing the progression
of restenosis and to compare the effectiveness of drug application through a slow releasing or moderate releasing method. It was
hypothesized that if the amount of neointimal area was compared between sirolimus and paclitaxel stents, then the change in area
resulting from sirolimus treatment would be less. This is because sirolimus inhibits mTOR. Also, if the amount of area was compared
between slow and moderate releasing stents, then the change in area resulting from the moderate releasing stent would be less. This is
because the reduction of neointimal proliferation is dose dependent.

Procedure: Data on neointimal area was collected and compared from data bases.

Conclusion: Neither of the hypotheses were supported. The data collected supports paclitaxels mechanism of reducing neointimal
proliferation. The data showed that restenosis was occurring regardless of the treatment. It was also concluded that when the drug is
applied through a slow releasing mechanism, the treatment is more effective. Overall, the combination of slow releasing method paired
with the paclitaxel was the most effective in reducing neointimal area change and therefore it would be the most effective in treating
restenosis with.

1) Limit Abstract to 3 paragraphs (about 200 words or less). a) Purpose - what you set out to investigate; b) Procedure - how you did
it; c) Conclusion - based on your results. Label each paragraph.
2) Must be typed, single-spaced on the front of this form. Do not write on the back of this form.
3) Three copies of your complete paper are required at the State Science Project Exposition.
Four copies of your complete paper are required for the State Paper Session Competition.

This form must be used. This form must be displayed on the front of the exhibitors display board. It may be reduced to half a sheet of paper;
8.5 inches (vertical) X 5.5 inches (horizontal).