+

Immune Pharmacology
Shan Nanji
+ 2

Immuno Pharmacology

nCyclosporine
n Binds to __________________

n Inhibits __________________which prevents production

of I __________________and its receptor.

Shan Nanji - NanjiMD@gmail.com

+ 3

Immuno Pharmacology

nTacrolimus TacrolimBBus
n Aka FK506
n Inhibits __________________
S/E:
n Nephrotoxicity
n __________________
n __________________
n Hyperglycemia
n __________________

Shan Nanji - NanjiMD@gmail.com

+ 4

Immuno Pharmacology

nSirolimus SEEroLIMus
n Aka Rapamycin
n __________________

n Limits __________________ proliferation

S/E
n __________________
n Thrombocytopenia
n Leukopenia

Shan Nanji - NanjiMD@gmail.com

+ 5

Immuno Pharmacology

nDaclizumab DA-Klizumab
n Antibody against __________________
n Clinical Use:

n DA-Kidney Transplants

Shan Nanji - NanjiMD@gmail.com

+ 6

Immuno Pharmacology

nAzathioprine
n Antimetabolite precursor __________________ that interferes
with metabolism and synthesis of nucleic acids.
n Clinical Use:
n Kidney Transplantation
n __________________
S/E:
n __________________, active metabolite Mercaptopurine
is metabolized by Xanthine Oxidase
n Toxic effects increased on __________________.

Shan Nanji - NanjiMD@gmail.com

+ 7

Immuno Pharmacology

nMuromonab Morononab
n Monocolonal AB that binds to __________________ on the
surface of T-Cells - __________________
n __________________

n Clinical Use:
n Immunosuppression after Kidney Transplantation

S/E:
n Cytokine Release Syndrome
n Hypersensitivty

Shan Nanji - NanjiMD@gmail.com

+ 8

Immuno Pharmacology

nTrastuzumab/Herceptin
TRUSTuzumab
n Target: erb-B2
n Clinical Use:
n Her-2 overexpressing Breast Cancer

n DONT TRUST HER

Shan Nanji - NanjiMD@gmail.com

+ 9

Immuno Pharmacology

nRituximab
n Target: CD20
n Clinical Use:

n __________________

Shan Nanji - NanjiMD@gmail.com

+ 10

Immuno Pharmacology

nInfliximab INFL-iximab
n Target: __________________
n Clinical Use:

n Crohns Disease

n Rheumatoid Arthritis

n Psoriatic Arthritis

n Ankylosing Spondylitis

Shan Nanji - NanjiMD@gmail.com

+ 11

Immuno Pharmacology

nAdalimumab
n Target: TNF-Alpha
n Clinical Use:

n Crohns Disease

n Rheumatoid Arthritis

n Psoriatic Arthritis

Shan Nanji - NanjiMD@gmail.com

+ 12

Immuno Pharmacology

nEtanercept
n Target: __________________
n Clinical Use:

n Crohns Disease

n Rheumatoid Arthritis

n Psoriatic Arthritis

Shan Nanji - NanjiMD@gmail.com

+ 13

Immuno Pharmacology

nDigoxin Immune Fab

n Target: Digoxin
n Clinical Use:

n Digoxin poisoning

Shan Nanji - NanjiMD@gmail.com

+ 14

Immuno Pharmacology

nAbciximab
n Target: __________________
n Clinical Use:
Prevents Cardiac Ischemia in:
n Unstable Angina
n Percutaneous Coronary Intervention Patients
n Current Myocardial Infarction Patients

Shan Nanji - NanjiMD@gmail.com

+ 15

Immuno Pharmacology

nOmalizumab
n Target __________________
n Clinical Use:
n Treatment option for __________________

Shan Nanji - NanjiMD@gmail.com

+ 16

Immuno Pharmacology

nMycophenolate
n Target __________________Prevents Production of the
Nucleoside Guanine
n Leads to rapid arrest of B/T cell proliferation

n Clinical Use:
n Transplants

n __________________

Shan Nanji - NanjiMD@gmail.com

+ 17

Immuno Pharmacology

nThalidomide (AKA Contergan)

n Target: __________________
n Clinical Use:
n Immunosupression:

n __________________
n Organ Transplants
n Anti-Angiogenic

Shan Nanji - NanjiMD@gmail.com

+ 18

Immuno Pharmacology
nThalidomide (AKA Contergan)
nS/E:
n __________________ (fetal development problems)
n Underdeveloped/malformed limbs and bones
n Encephalocele
n Hydrocephalus
n Leads to Vomiting and Migraines
n Bicornate Uterus
n Heart and Kidney Malformations
n Urethral Abnormalities
n Short Stature

Shan Nanji - NanjiMD@gmail.com

+ 19

Immuno Pharmacology

nAldesleukin
n Interleukin-2 Recombinant Cytokine
n Clinical Use:
n Renal Cell Carcinoma
n Metastatic Melanoma

Shan Nanji - NanjiMD@gmail.com

+ 20

Immuno Pharmacology

nErythropoietin
n Epoetin Recombinant Cytokine
n Clinical Use:
n Anemias
n In Renal Failure Especially Due to
EPO not being produced

Shan Nanji - NanjiMD@gmail.com

+ 21

Immuno Pharmacology

nFilgrastim FilGRA STIM

n ________________________________
n IL-___
n Clinical Use:
n _____________________

Shan Nanji - NanjiMD@gmail.com

+ 22

Immuno Pharmacology

nSargramostim SarGRA MoSTIM

n _____________________
n IL-3
n Clinical Use:
n _____________________

Shan Nanji - NanjiMD@gmail.com

+ 23

Immuno Pharmacology

n-Interferon
n Recombinant Cytokine
n Clinical Use:
n _____________________
n KaposisSarcoma
n _____________________
n Malignant Melanoma

Shan Nanji - NanjiMD@gmail.com

+ 24

Immuno Pharmacology

n-Interferon
n Recombinant Cytokine
n Clinical Use:
n _____________________

Shan Nanji - NanjiMD@gmail.com

+ 25

Immuno Pharmacology

n-Interferon
n Recombinant Cytokine
n Clinical Use:
n _____________________
n Aids Phagocytes

Shan Nanji - NanjiMD@gmail.com

+ 26

Immuno Pharmacology

nOprelvekin
n _____________________ Recombinant Cytokine
n Clinical Use:
n Thrombocytopenia

Shan Nanji - NanjiMD@gmail.com

+ 27

Immuno Pharmacology

nThrombopoietin
n Recombinant Cytokine
n Clinical Use:
n Thrombocytopenia

Shan Nanji - NanjiMD@gmail.com