Fransiska Dale

Pd. 6
Abstract
A diagnosis of high-grade squamous intraepithelial lesion (HSIL) indicates that high-
grade cervical intraepithelial neoplasia (CIN 2/3) has been detected on a Pap test, which could
lead to cervical cancer if not treated appropriately. If the endocervix is involved, it could have
glandular involvement by HSIL (HSIL-GI). While the Bethesda System for Reporting Cervical
Cytology does not have a separate HSIL-GI diagnostic category, the Johns Hopkins Hospital has
maintained this distinction.
The purpose of this retrospective study will determine if a diagnosis of HSIL-GI is useful
in predicting glandular involvement by HSIL, which studies have shown to be associated with
recurrent dysplasia. To conduct this study, we compared the Pap tests of patients ultimately
diagnosed with glandular involvement by HSIL to those with HSIL without glandular
involvement as the control group to determine the accuracy of a diagnosis of HSIL-GI on Pap
test at JHH. In addition, we will look at the actual diagnosis of HSIL-GI on the Pap smear to see
how often that correlated to a final diagnosis of glandular involvement by HSIL. After
completing the research, all the information will be used to create a manuscript for publication in
a peer-reviewed scientific journal. While our data indicates that a Pap test diagnosis of HSIL-GI
does not significantly predict glandular involvement by HSIL, we have found that patients with
HSIL-GI have statistically different Pap test diagnoses than those with HSIL.