PATENTS

1. Skin external agent of the present invention, coloring over time suppressed, in view of
arbutin whitening effect expression, preferably the pH is 4-7, and more particularly
preferably in the 4.5 to 6.5.

Patent : External preparation for skin

Publication number : JP2005120032A
Publication date : 12-05-2005
Link : https://patents.google.com/patent/JP2005120032A/en?
q=arbutine&q=ph&page=1

2. Present invention provides a novel skin whitening composition minimizing skin irritation
and maximizing stability by mixing arbutin and glucosidase just before applying to the skin.

Patent : Skin whitening composition containing arbutin and glucosidase as

active ingredient
Publication number : US20040042984A1
Publication date : 4-03-2004
Link :
https://patentimages.storage.googleapis.com/pdfs/682a671e5725ad230bd9/US2004004298
4A1.pdf

3. This invention additionally teaches the serum-liposome admixture being further admixed
into a gel or cream carrier as an advanced delivery system used in cosmetic, esthetician,
spa and dermatology office settings.

Patent : Topical cosmetic compositions containing alpha arbutin

Publication number : US7431949B2
Publication date : 07-10-2008

Link :
https://patentimages.storage.googleapis.com/pdfs/4e552f5d3259a5af5595/US7431949.pdf

4. Aqueous composition comprising active ingredients for the de-pigmentation of the skin

Patent : Aqueous composition comprising active ingredients for the de-

pigmentation of the skin
Publication number : US6123959A
Publication date : 26-09-2000

Link :
https://patentimages.storage.googleapis.com/pdfs/f46f4fcd810f7108cf44/US6123959.pdf
5. The arbutin liposomeprovided by the invention, by virtue of a wrapping effect of
phospholipid microcapsules, can enhance the lipid solubility of arbutin and then enhance the
transdermal ability of arbutin.

Patent : Arbutin liposome and preparation method thereof

Publication number : CN104586639A
Publication date : 06-05-2015
Link : https://patents.google.com/patent/CN104586639A/en?
q=arbutin&q=liposome&page=2

6. arbutin monoesters are employed in a composition for topical application, as a

depigmenting and/or bleahing agent for human skin, hair and/or head hair

Patent : Use of arbutin monoesters as depigmenting agents

Publication number : US6306376B1
Publication date : 23-10-2001
Link : https://patents.google.com/patent/US6306376B1/en?
q=use&q=arbutin&q=monoesters&q=depigmenting+agents