80% of b1 is removed in the husk (inner layer) of the polished rice by the

milling process if unpolished rice the inner layer is intact. if you wash the rice

2 times you remove another 5% of b1

 "mal delarosa"-initial lesions. pinkish

discoloration

dogs-sloughing off the outer lining of

buccal lining "black tongue"

ketogenesis

do not give high dose of niacin- makes the situation severe

oxalate stones-, glyoxalate->glycine with b6

accumulation of glyoxalate with def. of b6 causes stones hyperhomocystinemia- early hypertension ; injures lining of blood vessels.
- can also be caused by large doses of vit. c

- convulsive seizures

deficiency can be caused by intake of foods antagonist to the

action of pantothenic acid

depression- manifestation of PA deficiency

 - reactions where you add CO2. CO2 fixation

-major anaphlerotic reaction/ pampalit sa krebs

7. synthesis of purines

- loss of hair around the eyes

causes depression and hallucinations -has glutamic acid in structure

n5 methyl folic acid - most abundant

active form

THFA- Purine, Pyrimidine- DNA- cell growth, cell multiplication,

NADPH- reducing agent

cell maturation
folate reductase and vit.c - coenzymes