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Tree in bud sign is a CT appearance of multiple areas of centrilobular nodules with a branching pattern -

indicates bronchiole obstruction (smallest airway)

Causes

Endobronchial TB

Also in infections like mycobacterium avium intracellulare ,

Chronic aspiration pneumonia

Brochopneumonia

Cystic fibrosis

Sjogrens , Rheumatoid Arthritis

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